TY  - JOUR
TI  - Sociodemographic characteristics and clinical risk factors of Helicobacter pylori infection and antibiotic resistance in the Eastern Black Sea region of Turkey
AB  - Background/Aims: The aim of this study was to assess the clinical and sociodemographic risk factors of Helicobacter pylori infectionand antibiotic resistance in the eastern Black Sea region of Turkey.Materials and Methods: In total, 344 patients with dyspeptic symptoms who completed an extended questionnaire were enrolled in thestudy. Diagnosis of H. pylori infection was made by rapid urease test, histopathological investigation, and culture. Susceptibility of H.pylori strains was assessed by agar dilution (amoxicillin, tetracycline, metronidazole, levofloxacin) and E-test (clarithromycin) methods.Results: The H. pylori positivity rate was 40.4% (139/344). Logistic regression analysis indicated that age and the presence of duodenalulcer were independent risk factors associated with H. pylori positivity (odds ratio (OR): 0.96, 95% CI: 0.93–0.99, p=0.013; OR: 5.42, 95%CI: 1.96–14.98, p=0.001, respectively). Of 104 H. pylori-positive cultures, 43 strains (41%) were susceptible to all antibiotics, whereas 61(59%) were resistant to at least one antibiotic. H. pylori resistance rates were 34% for levofloxacin, 31.1% for metronidazole, 28.2% forclarithromycin, 2.9% for amoxicillin, and 1% for tetracycline. Logistic regression analysis indicated that previous use of clarithromycinwas the only independent risk factor for H. pylori resistance (OR: 6.25, 95% CI: 1.59-24.52, p=0.009).Conclusion: An understanding of the risk factors for H. pylori positivity and antibiotic resistance in an extended anamnesis may affecttreatment choice and facilitate H. pylori eradication. In regions where antibiotic resistance rates are elevated, performing antibioticsusceptibility tests may lead to effective eradication treatment.
AU  - UZUN, Doğan Yusuf
AU  - erkut, murat
AU  - ozgur, orhan
AU  - Arslan, Mehmet
AU  - AKYILDIZ, Esma
AU  - KAKLIKKAYA, NESE
AU  - COŞAR, Arif Mansur
AU  - YOĞUN, Yaşar
AU  - FİDAN, Sami
AU  - Topbas, Murat
DO  - 10.5152/tjg.2020.18631
PY  - 2020
JO  - Turkish Journal of Gastroenterology
VL  - 31
IS  - 3
SN  - 1300-4948
SP  - 221
EP  - 233
DB  - TRDizin
UR  - http://search/yayin/detay/459817
ER  -