Drug-Associated Thrombocytopenia as a Rare and Devastating Side Effect of Octreotide in a Cirrhotic Patients: A Case Report and Current Literature Review
Yıl: 2021 Cilt: 59 Sayı: 3 Sayfa Aralığı: 265 - 267 Metin Dili: İngilizce DOI: 10.4274/haseki.galenos.2021.6775 İndeks Tarihi: 17-11-2021
Drug-Associated Thrombocytopenia as a Rare and Devastating Side Effect of Octreotide in a Cirrhotic Patients: A Case Report and Current Literature Review
Öz: Variceal bleeding is one of the most serious outcomes encountered in portal hypertension. It represents one of the leading causesof death in cirrhotic patients. Octreotide infusion is the mainstay of treatment in variceal bleeding. It shows its effects by loweringportal venous pressure. Here, we present a patient with variceal bleeding who experienced sudden thrombocytopenia after octreotideinfusion. Cessation of the octreotide therapy has resulted in a quick recovery of the platelet counts. Naranjo adverse drug reactionprobability scale has revealed a probable relationship with 6 points. The case is reported in discussion with the existing 4 cases in theliterature.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
- 1. D’Amico G, De Franchis R; Cooperative Study Group. Upper digestive bleeding in cirrhosis. Post-therapeutic outcome and prognostic indicators. Hepatology 2003;38:599-612.
- 2. Bañares R, Albillos A, Rincón D, et al. Endoscopic treatment versus endoscopic plus pharmacologic treatment for acute variceal bleeding: a meta-analysis. Hepatology 2002;35:609- 15.
- 3. Gøtzsche PC, Hróbjartsson A. Somatostatin analogues for acute bleeding oesophageal varices. Cochrane Database Syst Rev 2008;2008:CD000193.
- 4. Hanna WT, Maull KI. Sandostatin-induced thrombocytopenia. South Med J 1990;83:77.
- 5. Demirkan K, Fleckenstein JF, Self TH. Thrombocytopenia associated with octreotide. Am J Med Sci 2000;320:296-7.
- 6. Chisholm S, Gummadi B, Vega KJ, House J. Sandostatin causing reversible thrombocytopenia. Eur J Gastroenterol Hepatol 2009;21:474-5.
- 7. Rashidi A, Rizvi N. Octreotide-induced thrombocytopenia: a case report. J Med Case Rep 2011;5:286.
- 8. Aster RH, Bougie DW. Drug-induced immune thrombocytopenia. N Engl J Med 2007;357:580-7.
- 9. Christie DJ, Mullen PC, Aster RH. Fab-mediated binding of drugdependent antibodies to platelets in quinidine- and quinineinduced thrombocytopenia. J Clin Invest 1985;75:310-4.
- 10. Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30:239-45.
| APA | Altintop S, Guven A, Keskin O (2021). Drug-Associated Thrombocytopenia as a Rare and Devastating Side Effect of Octreotide in a Cirrhotic Patients: A Case Report and Current Literature Review. , 265 - 267. 10.4274/haseki.galenos.2021.6775 |
| Chicago | Altintop Sabri Engin,Guven Alper Tuna,Keskin Onur Drug-Associated Thrombocytopenia as a Rare and Devastating Side Effect of Octreotide in a Cirrhotic Patients: A Case Report and Current Literature Review. (2021): 265 - 267. 10.4274/haseki.galenos.2021.6775 |
| MLA | Altintop Sabri Engin,Guven Alper Tuna,Keskin Onur Drug-Associated Thrombocytopenia as a Rare and Devastating Side Effect of Octreotide in a Cirrhotic Patients: A Case Report and Current Literature Review. , 2021, ss.265 - 267. 10.4274/haseki.galenos.2021.6775 |
| AMA | Altintop S,Guven A,Keskin O Drug-Associated Thrombocytopenia as a Rare and Devastating Side Effect of Octreotide in a Cirrhotic Patients: A Case Report and Current Literature Review. . 2021; 265 - 267. 10.4274/haseki.galenos.2021.6775 |
| Vancouver | Altintop S,Guven A,Keskin O Drug-Associated Thrombocytopenia as a Rare and Devastating Side Effect of Octreotide in a Cirrhotic Patients: A Case Report and Current Literature Review. . 2021; 265 - 267. 10.4274/haseki.galenos.2021.6775 |
| IEEE | Altintop S,Guven A,Keskin O "Drug-Associated Thrombocytopenia as a Rare and Devastating Side Effect of Octreotide in a Cirrhotic Patients: A Case Report and Current Literature Review." , ss.265 - 267, 2021. 10.4274/haseki.galenos.2021.6775 |
| ISNAD | Altintop, Sabri Engin vd. "Drug-Associated Thrombocytopenia as a Rare and Devastating Side Effect of Octreotide in a Cirrhotic Patients: A Case Report and Current Literature Review". (2021), 265-267. https://doi.org/10.4274/haseki.galenos.2021.6775 |
| APA | Altintop S, Guven A, Keskin O (2021). Drug-Associated Thrombocytopenia as a Rare and Devastating Side Effect of Octreotide in a Cirrhotic Patients: A Case Report and Current Literature Review. Haseki Tıp Bülteni, 59(3), 265 - 267. 10.4274/haseki.galenos.2021.6775 |
| Chicago | Altintop Sabri Engin,Guven Alper Tuna,Keskin Onur Drug-Associated Thrombocytopenia as a Rare and Devastating Side Effect of Octreotide in a Cirrhotic Patients: A Case Report and Current Literature Review. Haseki Tıp Bülteni 59, no.3 (2021): 265 - 267. 10.4274/haseki.galenos.2021.6775 |
| MLA | Altintop Sabri Engin,Guven Alper Tuna,Keskin Onur Drug-Associated Thrombocytopenia as a Rare and Devastating Side Effect of Octreotide in a Cirrhotic Patients: A Case Report and Current Literature Review. Haseki Tıp Bülteni, vol.59, no.3, 2021, ss.265 - 267. 10.4274/haseki.galenos.2021.6775 |
| AMA | Altintop S,Guven A,Keskin O Drug-Associated Thrombocytopenia as a Rare and Devastating Side Effect of Octreotide in a Cirrhotic Patients: A Case Report and Current Literature Review. Haseki Tıp Bülteni. 2021; 59(3): 265 - 267. 10.4274/haseki.galenos.2021.6775 |
| Vancouver | Altintop S,Guven A,Keskin O Drug-Associated Thrombocytopenia as a Rare and Devastating Side Effect of Octreotide in a Cirrhotic Patients: A Case Report and Current Literature Review. Haseki Tıp Bülteni. 2021; 59(3): 265 - 267. 10.4274/haseki.galenos.2021.6775 |
| IEEE | Altintop S,Guven A,Keskin O "Drug-Associated Thrombocytopenia as a Rare and Devastating Side Effect of Octreotide in a Cirrhotic Patients: A Case Report and Current Literature Review." Haseki Tıp Bülteni, 59, ss.265 - 267, 2021. 10.4274/haseki.galenos.2021.6775 |
| ISNAD | Altintop, Sabri Engin vd. "Drug-Associated Thrombocytopenia as a Rare and Devastating Side Effect of Octreotide in a Cirrhotic Patients: A Case Report and Current Literature Review". Haseki Tıp Bülteni 59/3 (2021), 265-267. https://doi.org/10.4274/haseki.galenos.2021.6775 |
