Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode
Yıl: 2021 Cilt: 7 Sayı: 1 Sayfa Aralığı: 207 - 218 Metin Dili: İngilizce DOI: 10.29132/ijpas.855881 İndeks Tarihi: 29-07-2022
Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode
Öz: In this study, it was aimed to use pyrrole monomer and single-walled carbon nanotube (SWCNT) in the productionof modified electrodes, and to examine the electrochemical properties of these electrodes. Bulk electrolysis technique wasused for growing polypyrrole. The applicability of the polypyrrole and SWCNT-based electrodes was tested byelectrochemically detecting active substances such as levodopa (LD) and benserazide (BS) used in the treatment ofParkinson's disease. During the design and analysis phase of the modified electrode, many electroanalytical optimizationand validation parameters were examined. The developed modified electrode gave linear responses with DPV techniquein concentration ranges of 10 - 50 µM for LD and 10 - 50 µM for BS. In addition, limits of detection in these wide linearranges were obtained as very low. Limits of detection were calculated as 2.4 µM and 1.2 µM for LD and BS, respectively.In addition, the applicability of the designed electrode and method was tested in urine and drug samples. The selectivityof this electrode was carried out in placebo solutions containing the interfering species. It is advantageous that the drugactive ingredients are easily, selectively and quickly determined at this modified electrode in the presence of componentsthat affect the analysis. Eventually, very satisfactory results in terms of analytical performance and applicability havebeen achieved with the designed electrode
Anahtar Kelime: Polipirol ve Tek Duvarlı Karbon Nanotüp Temelli Elektrotta Levodopa ve Benserazidin Voltametrik Tayini
Öz: Bu çalışmada, modifiye elektrot üretiminde pirol monomeri ve tek duvarlı karbon nanotüp (SWCNT) kullanılması ve bu elektrotların elektrokimyasal özelliklerinin incelenmesi amaçlanmıştır. Polipirolü büyütmek için yığın elektroliz tekniği kullanılmıştır. Polipirol ve SWCNT temelli elektrotların uygulanabilirliği, Parkinson hastalığı tedavisinde kullanılan levodopa (LD) ve benserazid (BS) gibi etken maddelerinin elektrokimyasal olarak saptanmasıyla test edilmiştir. Modifiye elektrotun tasarımı ve analiz aşamasında, elektroanalitik optimizasyon ve doğrulama parametreleri incelenmiştir. Geliştirilen modifiye elektrot, LD için 10 - 50 µM ve BS için 10 - 50 µM derişim aralıklarında, diferansiyel puls voltametri tekniği ile doğrusal yanıtlar vermiştir. Ayrıca bu geniş lineer aralıklardaki tayin limitleri çok düşük olarak elde edilmiştir. LD ve BS için tayin sınırları sırasıyla 2.4 µM ve 1.2 µM olarak hesaplandı. Ayrıca, tasarlanan elektrot ve yöntemin uygulanabilirliği idrar ve ilaç örneklerinde test edilmiştir. Bu elektrotun seçiciliği, girişim yapan türleri içeren plasebo çözeltilerinde gerçekleştirildi. İlaç etken maddelerinin, analizi etkileyen bileşenlerin varlığında bu modifiye edilmiş elektrotta kolayca, seçici ve hızlı bir şekilde tayin edilmesi avantajlıdır. Sonuç olarak, tasarlanan elektrot ile analitik performans ve uygulanabilirlik açısından çok tatmin edici sonuçlar elde edilmiştir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Kuyumcu Savan E, ERDOGDU G (2021). Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode. , 207 - 218. 10.29132/ijpas.855881 |
| Chicago | Kuyumcu Savan Ebru,ERDOGDU GAMZE Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode. (2021): 207 - 218. 10.29132/ijpas.855881 |
| MLA | Kuyumcu Savan Ebru,ERDOGDU GAMZE Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode. , 2021, ss.207 - 218. 10.29132/ijpas.855881 |
| AMA | Kuyumcu Savan E,ERDOGDU G Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode. . 2021; 207 - 218. 10.29132/ijpas.855881 |
| Vancouver | Kuyumcu Savan E,ERDOGDU G Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode. . 2021; 207 - 218. 10.29132/ijpas.855881 |
| IEEE | Kuyumcu Savan E,ERDOGDU G "Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode." , ss.207 - 218, 2021. 10.29132/ijpas.855881 |
| ISNAD | Kuyumcu Savan, Ebru - ERDOGDU, GAMZE. "Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode". (2021), 207-218. https://doi.org/10.29132/ijpas.855881 |
| APA | Kuyumcu Savan E, ERDOGDU G (2021). Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode. International Journal of Pure and Applied Sciences, 7(1), 207 - 218. 10.29132/ijpas.855881 |
| Chicago | Kuyumcu Savan Ebru,ERDOGDU GAMZE Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode. International Journal of Pure and Applied Sciences 7, no.1 (2021): 207 - 218. 10.29132/ijpas.855881 |
| MLA | Kuyumcu Savan Ebru,ERDOGDU GAMZE Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode. International Journal of Pure and Applied Sciences, vol.7, no.1, 2021, ss.207 - 218. 10.29132/ijpas.855881 |
| AMA | Kuyumcu Savan E,ERDOGDU G Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode. International Journal of Pure and Applied Sciences. 2021; 7(1): 207 - 218. 10.29132/ijpas.855881 |
| Vancouver | Kuyumcu Savan E,ERDOGDU G Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode. International Journal of Pure and Applied Sciences. 2021; 7(1): 207 - 218. 10.29132/ijpas.855881 |
| IEEE | Kuyumcu Savan E,ERDOGDU G "Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode." International Journal of Pure and Applied Sciences, 7, ss.207 - 218, 2021. 10.29132/ijpas.855881 |
| ISNAD | Kuyumcu Savan, Ebru - ERDOGDU, GAMZE. "Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode". International Journal of Pure and Applied Sciences 7/1 (2021), 207-218. https://doi.org/10.29132/ijpas.855881 |
