Association of maternal serum trace elements with newborn screening-thyroid stimulating hormone

SERDAR, Muhittin; LEVİ, Cansu AKIN; TURAM, Cem; EROĞLU, MUSTAFA; Kumru, Pınar; ÜÇAL, Yasemin; KELEŞ, Zeynep Zülfiye YILDIRIM; AKSUNGAR, Fehime; MUCHU, Murat; ÖZPINAR, Aysel

doi:10.1515/tjb-2019-0372

Association of maternal serum trace elements with newborn screening-thyroid stimulating hormone

Yasemin ÜÇAL, (Acıbadem Mehmet Ali Aydınlar Üniversitesi, Tıbbi Biyokimya Bölümü,İstanbul, Türkiye)

Muhittin SERDAR, (Acıbadem Mehmet Ali Aydınlar Üniversitesi, Tıbbi Biyokimya Bölümü,İstanbul, Türkiye)

Cansu AKIN LEVİ, (Acıbadem Mehmet Ali Aydınlar Üniversitesi, Tıbbi Biyokimya Bölümü,İstanbul, Türkiye)

Zeynep Zülfiye YILDIRIM KELEŞ, (Acıbadem Mehmet Ali Aydınlar Üniversitesi, Tıbbi Biyokimya Bölümü,İstanbul, Türkiye)

Cem TURAM, (Acıbadem Mehmet Ali Aydınlar Üniversite, Tıp Fakültesi, İstanbul, Türkiye)

Pınar KUMRU, (Zeynep Kamil Araştırma ve Eğitim Hastanesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, İstanbul, Türkiye)

Murat MUCHU, (Haydarpaşa Gülhane Askeri Tatbikat Okulu ve Hastanesi Hastanesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, İstanbul, Türkiye)

Mustafa EROĞLU, (Haydarpaşa Numune Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, İstanbul, Türkiye)

Fehime AKSUNGAR, (Acıbadem Mehmet Ali Aydınlar Üniversitesi, Tıbbi Biyokimya Bölümü,İstanbul, Türkiye)

Aysel ÖZPINAR (Acıbadem Mehmet Ali Aydınlar Üniversite, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, İstanbul, Türkiye)

Türk Biyokimya Dergisi

1 0

Yıl: 2020 Cilt: 45 Sayı: 5 Sayfa Aralığı: 507 - 514 Metin Dili: İngilizce DOI: 10.1515/tjb-2019-0372 İndeks Tarihi: 18-11-2021

Association of maternal serum trace elements with newborn screening-thyroid stimulating hormone

Öz:

Objectives: Trace elements are essential in thyroid functioning as they incorporate into biologically important enzymes as cofactors. The placenta can either activate orinhibit the transfer of maternal trace elements to the unborn.An imbalance of maternal trace elements in pregnancy mayaffect both maternal and newborn thyroid function.Methods: Blood samples from 315 lactating mothers werecollected in the first 48 h after delivery and evaluated forselenium (Se), copper (Cu), manganese (Mn), and zinc (Zn)using flame atomic absorption spectroscopy (FAAS) andquadrupole inductively coupled plasma-mass spectrometer (ICP-MS). Thyroid hormones and auto-antibodies(thyroid-stimulating hormone (TSH), free T3 (fT3), free T3(fT4), anti–thyroid peroxidase (anti-TPO), and antithyroglobulin (anti-TG)) were analyzed in maternal blood using an electro-chemiluminescence immunoassay (ECLIA).Between 48 and 72 postpartum hours, spot blood sampleswere used for newborn screening-TSH measurement. Correlation and multivariate analyses were performed toevaluate the effect of maternal trace element levels onnewborn screening-TSH levels.Results: The medians (min-max) of maternal Se (45.16 µg/L (21.28–79.04)), Cu (210.10 µg/dL (117.04–390.64)), Mn(2.11 µg/L (0.20–3.46)), and Zn (0.43 mg/L (0.24–0.66))were determined. A positive correlation was detected between Zn and maternal TSH levels (r=0.12, p < 0.05).Newborn screening-TSH was significantly correlated withmaternal Cu (r=0.14, p < 0.01). Similarly, Cu exhibited weakassociations in clustering analysis while others sharedcommon clusters with newborn-screening TSH.Conclusions: There was no significant association betweenmost of the maternal serum trace elements and maternalthyroid hormone parameters, with an only exception between maternal Zn and maternal serum TSH. Finally, theassociation between maternal serum Cu levels and newbornscreening-TSH levels may highlight the importance ofmaternal Cu levels on the newborn thyroid health.

Anahtar Kelime:

[Yenidoğan Tiroid Stimülan Hormon Tarama Sonuçları ile Anne Serum Eser Element Düzeylerinin İlişkisi

Öz:

Amaç: Eser elementler, biyolojik öneme sahip enzimlerin yapısına kofaktör olarak dahil olur ve bu elementlerin tiroid fonksiyonunda da önemli görevleri vardır. Plasenta, anne eser elementlerinin fetüse transferini sağlar veya engeller. Gebelik süresinde anneye ait eser elementlerin dengesizliği, hem anne hem de yenidoğanın tiroid fonk siyonunu etkileyebilir. Gereç ve Yöntem: Doğumdan sonraki ilk 48 saatte, 315 anneden toplanan kan örnekleri, alev atomik absorpsiyon spektroskopisi (FAAS) ve indüktif eşleşmiş plazma kütle spektrometresi (ICP-MS) kullanılarak selenyum (Se), bakır (Cu), manganez (Mn) ve çinko (Zn) açısından değerlendir ildi. Tiroid hormonları ve otoantikorları (TSH, fT3, fT4, anti TPO ve anti-TG) elektrokemilüminesans immünoanaliz yöntemiyle tayin edildi. Yenidoğan TSH tarama sonuçları kullanılarak, anne serum eser element düzeylerinin yeni doğan TSH düzeylerine etkisi korelasyon ve çok değişkenli analizler ile belirlendi. Bulgular: Anne serum Se (45.16 µg/L (21.28–79.04)), Cu (210.10 µg/dL (117.04–390.64)), Mn (2.11 µg/L (0.20–3.46)) ve Zn (0.43 mg/L(0.24–0.66)) medyan değerleri (min-max) tespit edildi. Anne TSH düzeyi ile Zn düzeyi arasında pozitif korelasyon saptandı (r=0.12, p < 0.05). Yenidoğan TSH taraması sonucu, anne Cu düzeyi ile anlamlı korelasyon gösterdi (r=0.14, p < 0.01). Benzer şekilde, kümeleme ana lizine göre Cu diğer iz elementlere kıyasla yenidoğan TSH ile daha zayıf kümelendi. Sonuç: Anne serum eser elementlerinin çoğu ile anne tiroid hormonu parametreleri arasında anlamlı bir ilişki bulunmamakla birlikte, anne Zn ve anne serum TSH sev iyesi arasında istatistiksel anlamlı bir ilişki bulunmaktadır. Son olarak, anne serum Cu düzeyleri ile yenidoğan TSH tarama sonucu arasındaki ilişki, anne Cu düzeyinin yeni doğan tiroid sağlığı üzerindeki önemini vurgulamaktadır.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Agrawal P, Philip R, Saran S, Gutch M, Razi MS, Agroiya P, et al. Congenital hypothyroidism. Indian J Endocrinol Metab 2015;19: 221–7.
2. Bost M, Houdart S, Oberli M, Kalonji E, Huneau JF, Margaritis I, Dietary copper and human health: Current evidence and unresolved issues. J Trace Elem Med Biol 2016;35:107–15.
3. Kohrle J, Jakob F, Contempre B, Dumont JE. Selenium, the thyroid, and the endocrine system. Endocr Rev 2005;26:944–84.
4. Jordan D, Suck C, Veisseire M, Chazot G. Zinc may play a role in the regulation of thyrotropin function. Horm Res 1986;24: 263–8.
5. Mullur R, Liu YY, Brent GA. Thyroid hormone regulation of metabolism. Physiol Rev 2014:94;355–82.
6. Pasupathi P, Chandrasekar V, Kumar US. Evaluation of oxidative stress, enzymatic and non-enzymatic antioxidants and metabolic thyroid hormone status in patients with diabetes mellitus. Diabetes Metab Syndr Clin Res Rev 2009;3:160–5.
7. Karimi F, Omrani GR. Effects of selenium and vitamin C on the serum level of antithyroid peroxidase antibody in patients with autoimmune thyroiditis. J Endocrinol Invest 2019;42: 481–7.
8. Koch KA, Pena MM, Thiele DJ. Copper-binding motifs in catalysis, transport, detoxification and signaling. Chem Biol 1997;4:549–60.
9. Soldin OP, Aschner M. Effects of manganese on thyroid hormone homeostasis: potential links. Neurotoxicology 2007;28:951–6.
10. Lain S, Trumpff C, Grosse SD, Olivieri A, Van Vliet G. Are lower TSH cutoffs in neonatal screening for congenital hypothyroidism warranted?. Eur J Endocrinol 2017;177:D1–D12.
11. Büyükgebiz A. Newborn screening for congenital hypothyroidism. J. Clin Res Pediatr Endocrinol 2013;5(2 Suppl):8–12.
12. Rubino JT, Franz KJ. Coordination chemistry of copper proteins: how nature handles a toxic cargo for essential function. J Inorg Biochem 2012;107:129–43.
13. Frieden E. Perspectives on copper biochemistry. Clin Physiol Biochem 1986;4:11–9.
14. Tapiero H, Townsend DM, Tew KD. Trace elements in human physiology and pathology. Copper. Biomed Pharmacother 2003; 57:386–98.
15. Mittag J, Behrends T, Nordstrom K, Anselmo J, Vennstrom B, Schomburg L. Serum copper as a novel biomarker for resistance to thyroid hormone. Biochem J 2012;443:103–9.
16. Blasig S, Kuhnen P, Schuette A, Blankenstein O, Mittag J, Schomburg L. Positive correlation of thyroid hormones and serum copper in children with congenital hypothyroidism. J Trace Elem Med Biol 2016;37:90–5.
17. Rossipal E, Krachler M, Li F, Micetic-Turk D. Investigation of the transport of trace elements across barriers in humans: studies of placental and mammary transfer. Acta Paediatr 2000;89: 1190–5.
18. Puchkova L, Babich P, Zatulovskaia Y, Ilyechova E, Di Sole F. Copper metabolism of newborns is adapted to milk ceruloplasmin as a nutritive source of copper: overview of the current data. Nutrients 2018;10:1591.
19. Majewska U, Braziewicz J, Banas D, Kubala-Kukus A, Kucharzewski M., Waler J, et al. Zn concentration in thyroid tissue and whole blood of women with different diseases of thyroid. Biol Trace Elem Res 2001;80:193–9.
20. Ruz M, Codoceo J, Galgani J, Munoz L, Gras N, Muzzo S, et al. Single and multiple selenium-zinc-iodine deficiencies affect rat thyroid metabolism and ultrastructure. J Nutr 1999;129:174–80.
21. Kralik A, Eder K, Kirchgessner M. Influence of zinc and selenium deficiency on parameters relating to thyroid hormone metabolism. Horm Metab Res 1996;28:223–6.
22. Landex NL, Thomsen J, Kayser L. Methimazole increases H2O2 toxicity in human thyroid epithelial cells. Acta Histochem 2006; 108:431–9.
23. Sugawara M., Sugawara Y, Wen K, Giulivi C. Generation of oxygen free radicals in thyroid cells and inhibition of thyroid peroxidase. Exp Biol Med (Maywood) 2002;227:141–6.
24. Song Y, Driessens N, Costa M, De Deken X, Detours V, Corvilain B, et al. Roles of hydrogen peroxide in thyroid physiology and disease. J Clin Endocrinol Metab 2007;92:3764–73.
25. Negro R. Selenium and thyroid autoimmunity. Biologics 2008;2: 265–73.
26. Ventura M, Melo M, Carrilho F. Selenium and thyroid disease: from pathophysiology to treatment. Int J Endocrinol 2017;2017: 1297658.
27. Rayman MP. Selenium and human health. Lancet (London, England) 2012;379:1256–68.
28. Duntas LH, Benvenga S. Selenium: an element for life. Endocrine 2015;48:756–75.
29. Holley AK, Bakthavatchalu V, Velez-Roman JM, St Clair DK. Manganese superoxide dismutase: guardian of the powerhouse. Int J Mol Sci 2011;12:7114–62.
30. Nishida S, Nakano T, Kimoto S, Kusunoki T, Suzuki K, Taniguchi N, et al. Induction of manganese superoxide dismutase by thyroid stimulating hormone in rat thyroid cells. FEBS Lett 1997;416:69–71.
31. Erdogan M, Üstüner I, Cengiz B, Söylemez F, Çavdar AO. Effects of nutrition on zinc, folic acid, and vitamin B12 levels during pregnancy. Biol Trace Elem Res 2006;109:105.
32. Kilinc M, Coskun A, Bilge F, Imrek SS, Atli Y. Serum reference levels of selenium, zinc and copper in healthy pregnant women at a prenatal screening program in southeastern mediterranean region of Turkey. J Trace Elem Med Biol 2010;24:152–6.
33. American Academy of Pediatrics. Newborn screening for congenital hypothyroidism: recommended guidelines. Pediatrics 1993;91:1203–1209.
34. Centers for Disease Control and Prevention. Body mass index (BMI). Centers for Disease Control and Prevention, Atlanta, Georgia; 2017. Available from: https://www.cdc.gov/ healthyweight/assessing/bmi/index.html.

APA	ÜÇAL Y, SERDAR M, LEVİ C, KELEŞ Z, TURAM C, Kumru P, MUCHU M, EROĞLU M, AKSUNGAR F, ÖZPINAR A (2020). Association of maternal serum trace elements with newborn screening-thyroid stimulating hormone. , 507 - 514. 10.1515/tjb-2019-0372
Chicago	ÜÇAL Yasemin,SERDAR Muhittin,LEVİ Cansu AKIN,KELEŞ Zeynep Zülfiye YILDIRIM,TURAM Cem,Kumru Pınar,MUCHU Murat,EROĞLU MUSTAFA,AKSUNGAR Fehime,ÖZPINAR Aysel Association of maternal serum trace elements with newborn screening-thyroid stimulating hormone. (2020): 507 - 514. 10.1515/tjb-2019-0372
MLA	ÜÇAL Yasemin,SERDAR Muhittin,LEVİ Cansu AKIN,KELEŞ Zeynep Zülfiye YILDIRIM,TURAM Cem,Kumru Pınar,MUCHU Murat,EROĞLU MUSTAFA,AKSUNGAR Fehime,ÖZPINAR Aysel Association of maternal serum trace elements with newborn screening-thyroid stimulating hormone. , 2020, ss.507 - 514. 10.1515/tjb-2019-0372
AMA	ÜÇAL Y,SERDAR M,LEVİ C,KELEŞ Z,TURAM C,Kumru P,MUCHU M,EROĞLU M,AKSUNGAR F,ÖZPINAR A Association of maternal serum trace elements with newborn screening-thyroid stimulating hormone. . 2020; 507 - 514. 10.1515/tjb-2019-0372
Vancouver	ÜÇAL Y,SERDAR M,LEVİ C,KELEŞ Z,TURAM C,Kumru P,MUCHU M,EROĞLU M,AKSUNGAR F,ÖZPINAR A Association of maternal serum trace elements with newborn screening-thyroid stimulating hormone. . 2020; 507 - 514. 10.1515/tjb-2019-0372
IEEE	ÜÇAL Y,SERDAR M,LEVİ C,KELEŞ Z,TURAM C,Kumru P,MUCHU M,EROĞLU M,AKSUNGAR F,ÖZPINAR A "Association of maternal serum trace elements with newborn screening-thyroid stimulating hormone." , ss.507 - 514, 2020. 10.1515/tjb-2019-0372
ISNAD	ÜÇAL, Yasemin vd. "Association of maternal serum trace elements with newborn screening-thyroid stimulating hormone". (2020), 507-514. https://doi.org/10.1515/tjb-2019-0372

APA	ÜÇAL Y, SERDAR M, LEVİ C, KELEŞ Z, TURAM C, Kumru P, MUCHU M, EROĞLU M, AKSUNGAR F, ÖZPINAR A (2020). Association of maternal serum trace elements with newborn screening-thyroid stimulating hormone. Türk Biyokimya Dergisi, 45(5), 507 - 514. 10.1515/tjb-2019-0372
Chicago	ÜÇAL Yasemin,SERDAR Muhittin,LEVİ Cansu AKIN,KELEŞ Zeynep Zülfiye YILDIRIM,TURAM Cem,Kumru Pınar,MUCHU Murat,EROĞLU MUSTAFA,AKSUNGAR Fehime,ÖZPINAR Aysel Association of maternal serum trace elements with newborn screening-thyroid stimulating hormone. Türk Biyokimya Dergisi 45, no.5 (2020): 507 - 514. 10.1515/tjb-2019-0372
MLA	ÜÇAL Yasemin,SERDAR Muhittin,LEVİ Cansu AKIN,KELEŞ Zeynep Zülfiye YILDIRIM,TURAM Cem,Kumru Pınar,MUCHU Murat,EROĞLU MUSTAFA,AKSUNGAR Fehime,ÖZPINAR Aysel Association of maternal serum trace elements with newborn screening-thyroid stimulating hormone. Türk Biyokimya Dergisi, vol.45, no.5, 2020, ss.507 - 514. 10.1515/tjb-2019-0372
AMA	ÜÇAL Y,SERDAR M,LEVİ C,KELEŞ Z,TURAM C,Kumru P,MUCHU M,EROĞLU M,AKSUNGAR F,ÖZPINAR A Association of maternal serum trace elements with newborn screening-thyroid stimulating hormone. Türk Biyokimya Dergisi. 2020; 45(5): 507 - 514. 10.1515/tjb-2019-0372
Vancouver	ÜÇAL Y,SERDAR M,LEVİ C,KELEŞ Z,TURAM C,Kumru P,MUCHU M,EROĞLU M,AKSUNGAR F,ÖZPINAR A Association of maternal serum trace elements with newborn screening-thyroid stimulating hormone. Türk Biyokimya Dergisi. 2020; 45(5): 507 - 514. 10.1515/tjb-2019-0372
IEEE	ÜÇAL Y,SERDAR M,LEVİ C,KELEŞ Z,TURAM C,Kumru P,MUCHU M,EROĞLU M,AKSUNGAR F,ÖZPINAR A "Association of maternal serum trace elements with newborn screening-thyroid stimulating hormone." Türk Biyokimya Dergisi, 45, ss.507 - 514, 2020. 10.1515/tjb-2019-0372
ISNAD	ÜÇAL, Yasemin vd. "Association of maternal serum trace elements with newborn screening-thyroid stimulating hormone". Türk Biyokimya Dergisi 45/5 (2020), 507-514. https://doi.org/10.1515/tjb-2019-0372