TY  - JOUR
TI  - Association of maternal serum trace elements with newborn screening-thyroid stimulating hormone
AB  - Objectives: Trace elements are essential in thyroid functioning as they incorporate into biologically important enzymes as cofactors. The placenta can either activate orinhibit the transfer of maternal trace elements to the unborn.An imbalance of maternal trace elements in pregnancy mayaffect both maternal and newborn thyroid function.Methods: Blood samples from 315 lactating mothers werecollected in the first 48 h after delivery and evaluated forselenium (Se), copper (Cu), manganese (Mn), and zinc (Zn)using flame atomic absorption spectroscopy (FAAS) andquadrupole inductively coupled plasma-mass spectrometer (ICP-MS). Thyroid hormones and auto-antibodies(thyroid-stimulating hormone (TSH), free T3 (fT3), free T3(fT4), anti–thyroid peroxidase (anti-TPO), and antithyroglobulin (anti-TG)) were analyzed in maternal blood using an electro-chemiluminescence immunoassay (ECLIA).Between 48 and 72 postpartum hours, spot blood sampleswere used for newborn screening-TSH measurement. Correlation and multivariate analyses were performed toevaluate the effect of maternal trace element levels onnewborn screening-TSH levels.Results: The medians (min-max) of maternal Se (45.16 µg/L (21.28–79.04)), Cu (210.10 µg/dL (117.04–390.64)), Mn(2.11 µg/L (0.20–3.46)), and Zn (0.43 mg/L (0.24–0.66))were determined. A positive correlation was detected between Zn and maternal TSH levels (r=0.12, p < 0.05).Newborn screening-TSH was significantly correlated withmaternal Cu (r=0.14, p < 0.01). Similarly, Cu exhibited weakassociations in clustering analysis while others sharedcommon clusters with newborn-screening TSH.Conclusions: There was no significant association betweenmost of the maternal serum trace elements and maternalthyroid hormone parameters, with an only exception between maternal Zn and maternal serum TSH. Finally, theassociation between maternal serum Cu levels and newbornscreening-TSH levels may highlight the importance ofmaternal Cu levels on the newborn thyroid health.
AU  - SERDAR, Muhittin
AU  - LEVİ, Cansu AKIN
AU  - TURAM, Cem
AU  - EROĞLU, MUSTAFA
AU  - Kumru, Pınar
AU  - ÜÇAL, Yasemin
AU  - KELEŞ, Zeynep Zülfiye YILDIRIM
AU  - AKSUNGAR, Fehime
AU  - MUCHU, Murat
AU  - ÖZPINAR, Aysel
DO  - 10.1515/tjb-2019-0372
PY  - 2020
JO  - Türk Biyokimya Dergisi
VL  - 45
IS  - 5
SN  - 1303-829X
SP  - 507
EP  - 514
DB  - TRDizin
UR  - http://search/yayin/detay/461192
ER  -