Yıl: 2020 Cilt: 6 Sayı: 6 Sayfa Aralığı: 600 - 608 Metin Dili: İngilizce DOI: 10.18621/eurj.550724

A comparison of clinical, hepatic and immunological effects of three different parenteral lipid emulsions in children

Öz:
Objectives: Lipid emulsions are not only considered as a source of energy, but also as a regulatory substancefor key metabolic functions in different diseases. The aim of the present study was to compare clinical,biochemical and immunological effects of olive oil, soybean oil and omega-3 fatty acid which are administratedto the children in parenteral nutrition products.Methods: Patients who were admitted to pediatric intensive care unit and had parenteral nutrition for 7 daysare included in the study. The patients were randomised into 3 groups based on the admission order, including10 patients in each group. The children in Group O were fed by a lipid emulsion based on olive oil; the childrenin Group S were fed by a soybean based lipid emulsion and the children in group F were fed by soybean basedlipid emulsion with omega-3 based solution. Analysis were made on the first and the seventh day. Laboratoryparameters as well as hemogram, biochemical analysis, immunoglobulins, lymphocyte subgroup panel andcytokine levels were evaluated just before parenteral nutrition (day 0, basal value) and at day 7 of parenteralnutrition. Clinical monitoring parameters included body weight, and circumference of the mid-upper arm.Results: Thirty children were enrolled into the study. Total cholesterol and triglyceride levels significantlyincreased in Group O whereas triglyceride level significantly increased in Group S. Hemogram, liver functiontests, cytokine levels, lymphocyte sub-group distribution, immunoglobulin levels and total antioxidant capacitymeasurements were not different.Conclusions: Three lipid emulsions which are used for parenteral nutrition treatment in intensive care unitpatients are clinically and biochemically useful.
Anahtar Kelime:

Konular:
Fen > Tıp > Anatomi ve Morfoloji
Fen > Tıp > Androloji
Fen > Tıp > Biyofizik
Fen > Tıp > Biyokimya ve Moleküler Biyoloji
Fen > Tıp > Dermatoloji
Fen > Tıp > Acil Tıp
Fen > Tıp > Hematoloji
Fen > Tıp > Enfeksiyon Hastalıkları
Fen > Tıp > Tıbbi İnformatik
Fen > Tıp > Tıbbi Laboratuar Teknolojisi
Fen > Tıp > Nörolojik Bilimler
Fen > Tıp > Onkoloji
Fen > Tıp > Göz Hastalıkları
Fen > Tıp > Kulak, Burun, Boğaz
Fen > Tıp > Patoloji
Fen > Tıp > Romatoloji
Fen > Tıp > Spor Bilimleri
Fen > Tıp > Adli Tıp
Fen > Tıp > Tıbbi Araştırmalar Deneysel
Fen > Tıp > Periferik Damar Hastalıkları
Fen > Tıp > Üroloji ve Nefroloji
Fen > Tıp > Kadın Hastalıkları ve Doğum
Fen > Tıp > Geriatri ve Gerontoloji
Fen > Tıp > Temel Sağlık Hizmetleri
Fen > Tıp > Alerji
Fen > Tıp > Odyoloji ve Konuşma-Dil Patolojisi
Fen > Tıp > Biyoteknoloji ve Uygulamalı Mikrobiyoloji
Fen > Tıp > Hücre Biyolojisi
Fen > Tıp > Klinik Nöroloji
Fen > Tıp > Yoğun Bakım, Tıp
Fen > Tıp > Tıbbi Etik
Fen > Tıp > Ortopedi
Fen > Tıp > Pediatri
Fen > Tıp > Solunum Sistemi
Fen > Tıp > Cerrahi
Fen > Temel Bilimler > Biyoloji
Fen > Tıp > Halk ve Çevre Sağlığı
Fen > Tıp > Sağlık Bilimleri ve Hizmetleri
Fen > Tıp > Anestezi
Fen > Tıp > İmmünoloji
Fen > Tıp > Mikrobiyoloji
Fen > Tıp > Fizyoloji
Fen > Tıp > Psikiyatri
Fen > Tıp > Rehabilitasyon
Fen > Tıp > Transplantasyon
Fen > Tıp > Tropik Tıp
Fen > Tıp > Tamamlayıcı ve Entegre Tıp
Fen > Tıp > Genel ve Dahili Tıp
Fen > Tıp > Gastroenteroloji ve Hepatoloji
Fen > Tıp > Endokrinoloji ve Metabolizma
Fen > Tıp > Kalp ve Kalp Damar Sistemi
Fen > Tıp > Radyoloji, Nükleer Tıp, Tıbbi Görüntüleme
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Hojsak I, Colomb V, Braegger C, Bronsky J, Campoy C, Domellöf M, et al. ESPGHAN committee on nutrition position paper. Intravenous lipid emulsions and risk of hepatotoxicity in infants and children: a systematic review and meta-analysis. J Pediatr Gastroenterol Nutr 2016;62:776-92.
  • 2. Waitzberg DL, Torrinhas RS, Jacintho TM. New parenteral lipid emulsions for clinical use. J Parenter Enter Nutr 2006;30:351-67.
  • 3. Mayer K, Gokorsch S, Fegbeutel C, Hattar K, Rosseau S, Walmrath D, et al.Parenteral nutrition with fish oil modulates cytokine response in patients with sepsis. Am J Respir Crit Care Med 2003;167:1321-8.
  • 4. Wanten GJA. Parenteral lipid tolerance and adverse effects: fat chance for trouble? JPEN J Parenter Enteral Nutr 2015;39:33-8.
  • 5. Mehta NM, Compher C. A.S.P.E.N. Clinical Guidelines: nutrition support of the critically ill child. JPEN J Parenter Enteral Nutr 2009;33:260-76.
  • 6. Beaufrere B. Eflicacite nutritionnelle et metabolique de Cli nOleic 20%. Nutr Clin Metabol 1996;10:29-31.
  • 7. Goulet O, de Potter S, Antebi H, Driss F, Colomb V, Bereziat G, et al. Long-term efficacy and safety of a new olive oil-based intravenous fat emulsion in pediatric patients: a double-blind randomized study. Am J Clin Nutr 1999;70:338-45.
  • 8. Shulman RJ, Phillips S. Parenteral nutrition in infants and children. J Pediatr Gastroenterol Nutr 2003;36:587-607.
  • 9. Oshita M, Takehara H, Yamaguchi M, Doi K, Ueda N, Naito S, et al.Significance of administration of fat emulsion: hepatic changes in infant rats receiving total parenteral nutrition with and without fat. Clin Nutr 2004;23:1060-8.
  • 10. Dahlström KA, Goulet OJ, Roberts RL, Ricour C, Ament ME. Lipid tolerance in children receiving long-term parenteral nutrition: a biochemical and immunologic study. J Pediatr 1988;113:985-90.
  • 11. Ythier-Moury P, Dutot G, Melin C. Modifications of biliary secretion associated with parenteral nutrition in the rat: influence of fat emulsion composition. Clin Nutr 1990;9:26.
  • 12. Calder PC. Lipids and the critically ill patient. Nestle Nutr Workshop Ser Clin Perform Programme 2003;8:75-91.
  • 13. Calder PC, Jensen GL, Koletzko BV, Singer P, Wanten GJA. Lipid emulsions in parenteral nutrition of intensive care patients: current thinking and future directions. Intens Care Med 2010;36:735-49.
  • 14. Goren A, Stankiewicz H, Goldstein R, Drukker A. Fish oil treatment of hyperlipidemia in children and adolescents receiving renal replacement therapy. Pediatrics 1991;88:265-8.
  • 15. Calkins KL, Dunn JCY, Shew SB, Reyen L, Farmer DG, Devaskar SU, et al. Pediatric intestinal failure-associated liver disease is reversed with 6 months of intravenous fish oil. JPEN J Parenter Enteral Nutr 2014;38:682-92.
  • 16. Park Y, Harris WS. Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance. J Lipid Res 2003;44:455-63.
  • 17. Leite HP, de Carvalho WB, Fisberg M. Nutritional and metabolic assessment of critically ill children. Sao Paulo Med J 1996;114:1156-61.
  • 18. Delgado AF, Kimura HM, Cardoso AL, Uehara D, Carrazza FR. Nutritional follow-up of critically ill infants receiving short term parenteral nutrition. Rev Hosp Clin Fac Med Sao Paulo 2000;55:3-8.
  • 19. Xu Z, Harvey KA, Pavlina TM, Zaloga GP, Siddiqui RA. Tocopherol and tocotrienol homologs in parenteral lipid emulsions. Eur J Lipid Sci Technol 2015;117:15-22.
  • 20. Pironi L, Guidetti M, Zolezzi C, Fasano MC, Paganelli F, Merli C, et al. Peroxidation potential of lipid emulsions after compounding in all-in-one solutions. Nutrition 2003;19:784-8.
  • 21. Pironi L, Guidetti M, Zolezzi C, Fasano MC, Paganelli F, Merli C, et al. Liver function and plasma antioxidant status in intensive care unit patients requiring total parenteral nutrition: comparison of 2 fat emulsions. JPEN J Parenter Enteral Nutr 2004;28:142-8.
  • 22. Wanten GJ, Calder PC. Immune modulation by parenteral lipid emulsions. Am J Clin Nutr 2007;85:1171-84.
  • 23. Moussa M, Le Boucher J, Garcia J, Tkaczuk J, Ragab J, Dutot G, et al. In vivo effects of olive oil-based lipid emulsion on lymphocyte activation in rats. Clin Nutr 2000;19:49-54.
  • 24. Granato D, Blum S, Rössle C, Le Boucher J, Malnoë A, Dutot G. Effects of parenteral lipid emulsions with different fatty acid composition on immune cell functions in vitro. JPEN J Parenter Enteral Nutr 2000;24:113-8.
  • 25. Puertollano MA, Puertollano E, Ruiz-Bravo A, JiménezValera M, De Pablo MA, De Cienfuegos GA. Changes in the immune functions and susceptibility to Listeria monocytogenes infection in mice fed dietary lipids. Immunol Cell Biol 2004;82:370-6.
  • 26. Kumar GS, Das UN, Kumar KV, Madhavi N, Das NP, Tan BKH. Effect of n-6 and n-3 fatty acids on the proliferation of human lymphocytes and their secretion of TNF-α and IL-2 in vitro. Nutr Res 1992;12:815-23.
  • 27. Calder PC, Newsholme EA. Polyunsaturated fatty acids suppress human peripheral blood lymphocyte proliferation and interleukin-2 production. Clin Sci 1992;82:695-700.
  • 28. Schauder P, Röhn U, Schäfer G, Korff G, Schenk HD. Impact of fish oil enriched total parenteral nutrition on DNA synthesis, cytokine release and receptor expression by lymphocytes in the postoperative period. Br J Nutr 2002;87:103-10.
  • 29. Wu D, Meydani SN, Meydani M, Hayek MG, Huth P, Nicolosi RJ. Immunologic effects of marine- and plant-derived n-3 polyunsaturated fatty acids in nonhuman primates. Am J Clin Nutr 1996;63:273-80.
  • 30. Lapillonne A, Mis NF, Goulet O, van den Akker CH, Wu J, Koletzko B. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Lipids. Clin Nutr 2018;37:2324-36.
APA ÇAKIR S, ÖZKAN T, ÖZGÜR T (2020). A comparison of clinical, hepatic and immunological effects of three different parenteral lipid emulsions in children. The European Research Journal, 6(6), 600 - 608. 10.18621/eurj.550724
Chicago ÇAKIR Salih Çağrı,ÖZKAN Tanju Münevver Başarır,ÖZGÜR Taner A comparison of clinical, hepatic and immunological effects of three different parenteral lipid emulsions in children. The European Research Journal 6, no.6 (2020): 600 - 608. 10.18621/eurj.550724
MLA ÇAKIR Salih Çağrı,ÖZKAN Tanju Münevver Başarır,ÖZGÜR Taner A comparison of clinical, hepatic and immunological effects of three different parenteral lipid emulsions in children. The European Research Journal, vol.6, no.6, 2020, ss.600 - 608. 10.18621/eurj.550724
AMA ÇAKIR S,ÖZKAN T,ÖZGÜR T A comparison of clinical, hepatic and immunological effects of three different parenteral lipid emulsions in children. The European Research Journal. 2020; 6(6): 600 - 608. 10.18621/eurj.550724
Vancouver ÇAKIR S,ÖZKAN T,ÖZGÜR T A comparison of clinical, hepatic and immunological effects of three different parenteral lipid emulsions in children. The European Research Journal. 2020; 6(6): 600 - 608. 10.18621/eurj.550724
IEEE ÇAKIR S,ÖZKAN T,ÖZGÜR T "A comparison of clinical, hepatic and immunological effects of three different parenteral lipid emulsions in children." The European Research Journal, 6, ss.600 - 608, 2020. 10.18621/eurj.550724