SARS-CoV-2’ye Bağlı Organ Tutulumlarının Değerlendirilmesi:Geleneksel Derleme
Yıl: 2021 Cilt: 10 Sayı: 2 Sayfa Aralığı: 223 - 230 Metin Dili: Türkçe DOI: 10.5336/pharmsci.2021-81605 İndeks Tarihi: 19-11-2021
SARS-CoV-2’ye Bağlı Organ Tutulumlarının Değerlendirilmesi:Geleneksel Derleme
Öz: Şiddetli akut solunum yolu sendromu-koronavirüs-2 [severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)] enfeksiyonu damlacık yoluyla bulaşan bir solunum yolu hastalığı olarak ortaya çıkmasına rağmen, enfekte olan hastalarda solunum yolu dışındaki organlarda da çoklu organ tutulumları gözlenmiştir. Bu durum, SARSCoV-2’nin spike proteinin hücrelere girişi için anjiyotensin dönüştürücü enzim-2 [angiotensin converting enzyme-2 (ACE-2)] reseptörlerini kullanmasıyla ilişkilendirilmiştir. ACE-2 ekspresyonunun; akciğer, kalp, testis, ince bağırsak, tiroid, böbrek ve az miktarda beyinde olduğu bilinmektedir. Bu bilgiye dayanarak araştırmalar, SARS-CoV-2 enfeksiyonunda ACE-2 ekspresyonunun diğer organ ve sistemler üzerindekietkilerine yoğunlaşmıştır. Enfeksiyon sürecinde proinflamatuar yanıtların ve ACE-2 ekspresyonundaki artışın çoklu organ tutulumuna yol açtığı öne sürülmüştür. Ağır hastalardaki çoklu organ tutulumları hastanede kalış süresini uzatmakta ve ölüm oranlarının artmasına sebep olmaktadır. SAR-CoV-2 enfeksiyonuna bağlı gelişen kalp yetersizliği, böbrek yetersizliği, sitokin fırtınası, pıhtılaşma bozuklukları ve organ yetersizlikleri ölümü hızlandırmaktadır. SARS-CoV-2 enfeksiyonunun tedavi stratejileri belirlenirken çoklu organ hasarının altında yatan mekanizmaların bilinmesi, hastalık prognozunun iyileştirilmesi açısından önem taşımaktadır. Bu derlemede SARS-CoV-2 enfeksiyonunun neden olduğu çoklu organ tutulumlarına neden olan mekanizmalar ele alınmıştır.
Anahtar Kelime: The Assessment of Multiple Organ Involvement Due to SARS-CoV-2: Traditional Review
Öz: Although severe acute respiratory syndrome-coron avirus-2 (SARS-CoV-2) infection appears as a respiratory tract dis ease transmitted through droplets, multiple organ involvements havealso been observed in organs other than the respiratory tract in in fected patients. This has been associated with SARS CoV-2’s use ofangiotensin converting enzyme-2 (ACE-2) receptors to enter the spikeprotein into cells. ACE-2 expression is known to occur in the lung,heart, testis, small intestine, thyroid, kidney and a small amount ofthe brain. Based on this information, research has focused on the ef fects of ACE-2 expression on other organs and systems in SARS CoV-2 infection. It has been suggested that pro-inflammatoryresponses and increase in ACE-2 expression during the infection pro cess lead to multi-organ involvement. Multiple organ involvement inseriously ill patients prolongs the duration of hospital stay and causesan increase in mortality rates. Heart failure, kidney failure, cytokinestorm, coagulation disorders and organ failure due to SARS-CoV-2infection accelerate death. While determining the treatment strategiesof SARS-CoV-2 infection, it is important to know the mechanismsunderlying multiple organ damage in terms of improving the diseaseprognosis. In this review, the mechanisms that cause multiple organinvolvement caused by SARS-CoV-2 infection are discussed.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
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| APA | yüce h, ÜNÜVAR S (2021). SARS-CoV-2’ye Bağlı Organ Tutulumlarının Değerlendirilmesi:Geleneksel Derleme. , 223 - 230. 10.5336/pharmsci.2021-81605 |
| Chicago | yüce hande,ÜNÜVAR Songül SARS-CoV-2’ye Bağlı Organ Tutulumlarının Değerlendirilmesi:Geleneksel Derleme. (2021): 223 - 230. 10.5336/pharmsci.2021-81605 |
| MLA | yüce hande,ÜNÜVAR Songül SARS-CoV-2’ye Bağlı Organ Tutulumlarının Değerlendirilmesi:Geleneksel Derleme. , 2021, ss.223 - 230. 10.5336/pharmsci.2021-81605 |
| AMA | yüce h,ÜNÜVAR S SARS-CoV-2’ye Bağlı Organ Tutulumlarının Değerlendirilmesi:Geleneksel Derleme. . 2021; 223 - 230. 10.5336/pharmsci.2021-81605 |
| Vancouver | yüce h,ÜNÜVAR S SARS-CoV-2’ye Bağlı Organ Tutulumlarının Değerlendirilmesi:Geleneksel Derleme. . 2021; 223 - 230. 10.5336/pharmsci.2021-81605 |
| IEEE | yüce h,ÜNÜVAR S "SARS-CoV-2’ye Bağlı Organ Tutulumlarının Değerlendirilmesi:Geleneksel Derleme." , ss.223 - 230, 2021. 10.5336/pharmsci.2021-81605 |
| ISNAD | yüce, hande - ÜNÜVAR, Songül. "SARS-CoV-2’ye Bağlı Organ Tutulumlarının Değerlendirilmesi:Geleneksel Derleme". (2021), 223-230. https://doi.org/10.5336/pharmsci.2021-81605 |
| APA | yüce h, ÜNÜVAR S (2021). SARS-CoV-2’ye Bağlı Organ Tutulumlarının Değerlendirilmesi:Geleneksel Derleme. Literatür Eczacılık Bilimleri Dergisi, 10(2), 223 - 230. 10.5336/pharmsci.2021-81605 |
| Chicago | yüce hande,ÜNÜVAR Songül SARS-CoV-2’ye Bağlı Organ Tutulumlarının Değerlendirilmesi:Geleneksel Derleme. Literatür Eczacılık Bilimleri Dergisi 10, no.2 (2021): 223 - 230. 10.5336/pharmsci.2021-81605 |
| MLA | yüce hande,ÜNÜVAR Songül SARS-CoV-2’ye Bağlı Organ Tutulumlarının Değerlendirilmesi:Geleneksel Derleme. Literatür Eczacılık Bilimleri Dergisi, vol.10, no.2, 2021, ss.223 - 230. 10.5336/pharmsci.2021-81605 |
| AMA | yüce h,ÜNÜVAR S SARS-CoV-2’ye Bağlı Organ Tutulumlarının Değerlendirilmesi:Geleneksel Derleme. Literatür Eczacılık Bilimleri Dergisi. 2021; 10(2): 223 - 230. 10.5336/pharmsci.2021-81605 |
| Vancouver | yüce h,ÜNÜVAR S SARS-CoV-2’ye Bağlı Organ Tutulumlarının Değerlendirilmesi:Geleneksel Derleme. Literatür Eczacılık Bilimleri Dergisi. 2021; 10(2): 223 - 230. 10.5336/pharmsci.2021-81605 |
| IEEE | yüce h,ÜNÜVAR S "SARS-CoV-2’ye Bağlı Organ Tutulumlarının Değerlendirilmesi:Geleneksel Derleme." Literatür Eczacılık Bilimleri Dergisi, 10, ss.223 - 230, 2021. 10.5336/pharmsci.2021-81605 |
| ISNAD | yüce, hande - ÜNÜVAR, Songül. "SARS-CoV-2’ye Bağlı Organ Tutulumlarının Değerlendirilmesi:Geleneksel Derleme". Literatür Eczacılık Bilimleri Dergisi 10/2 (2021), 223-230. https://doi.org/10.5336/pharmsci.2021-81605 |
