Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities ofAgropyron repens and Crataegus monogyna Species

Deveci, Ebru; DURU, Mehmet Emin; KARAKURT, Serdar; ÇAYAN, Gülşen TEL

doi:10.26650/EurJBiol.2020.0077

Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities ofAgropyron repens and Crataegus monogyna Species

Ebru DEVECİ, (Konya Teknik Üniversitesi, Kimya ve Kimyasal İşleme Teknolojileri Bölümü, Konya, Türkiye)

Gülşen TEL ÇAYAN, (Muğla Sıtkı Koçman Üniversitesi, Kimya ve Kimyasal İşleme Teknolojileri Bölümü, Muğla, Türkiye)

Serdar KARAKURT, (Selçuk Üniversitesi, Fen Fakültesi, Biyokimya Bölümü, Konya, Türkiye)

Mehmet Emin DURU (Muğla Sıtkı Koçman Üniversitesi, Fen Fakültesi, Kimya Bölümü, Muğla, Türkiye)

European Journal of Biology

1 0

Yıl: 2020 Cilt: 79 Sayı: 2 Sayfa Aralığı: 98 - 105 Metin Dili: İngilizce DOI: 10.26650/EurJBiol.2020.0077 İndeks Tarihi: 21-11-2021

Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities ofAgropyron repens and Crataegus monogyna Species

Öz:

Objective: The aim of this study was to investigate antioxidant, enzyme inhibitory and cytotoxic activities of Agropyron repens and Crataegus monogyna methanol extracts with total phenolic and flavonoid contents. Materials and Methods: Total phenolic and flavonoid contents of A. repens and C. monogyna methanol extracts were measured according to Folin Ciocalteu and aluminum nitrate methods, respectively. Antioxidant and enzyme inhibitory activities of the methanol extracts were tested spectrophotometrically. Also, cytotoxic activities of the methanol extracts against DLD-1 and CCD-18Co were investigated by using Alamar Blue assay.Results: C. monogyna methanol extract with the highest total phenolic and flavonoid contents (68.13±0.34 µg GAEs/mg extract and 36.91±0.17 µg QEs/mg extract, respectively) had the best antioxidant activity in β-carotene-linoleic acid ($IC_50$: 32.72±0.15 µg/mL), CUPRAC ($A_0.50$: 282.69±0.25 µg/mL), DPPH• ($IC_50$: 71.69±0.85 µg/mL), and ABTS•+ ($IC_50$: 40.43±0.55 µg/mL) assays. A. repens methanol extract showed the highest effect against AChE (18.73±0.47 %), BChE (37.59±1.07 %), urease (89.18±0.84%), α-glucosidase (6.71±0.23 %), whereas C. monogyna methanol extract showed the highest effect against tyrosinase (30.52±1.00%) and α-amylase (37.24±0.06 %). Also, A. repens ($IC_50$: 57.38 µg/mL) and C. monogyna ($IC_50$: 54.04 µg/mL) methanol extracts showed close cytotoxic activity on DLD-1.Conclusion: Antioxidant, cytotoxic, and enzyme inhibitory activities of A. repens and C. monogyna methanol extracts were investigated with total phenolic and flavonoid contents in this study. The results obtained with this study strengthen the potential of the studied plants as a new source for the discovery of antioxidant, cytotoxic, and enzyme inhibitor agents.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Deveci E, ÇAYAN G, KARAKURT S, DURU M (2020). Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities ofAgropyron repens and Crataegus monogyna Species. , 98 - 105. 10.26650/EurJBiol.2020.0077
Chicago	Deveci Ebru,ÇAYAN Gülşen TEL,KARAKURT Serdar,DURU Mehmet Emin Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities ofAgropyron repens and Crataegus monogyna Species. (2020): 98 - 105. 10.26650/EurJBiol.2020.0077
MLA	Deveci Ebru,ÇAYAN Gülşen TEL,KARAKURT Serdar,DURU Mehmet Emin Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities ofAgropyron repens and Crataegus monogyna Species. , 2020, ss.98 - 105. 10.26650/EurJBiol.2020.0077
AMA	Deveci E,ÇAYAN G,KARAKURT S,DURU M Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities ofAgropyron repens and Crataegus monogyna Species. . 2020; 98 - 105. 10.26650/EurJBiol.2020.0077
Vancouver	Deveci E,ÇAYAN G,KARAKURT S,DURU M Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities ofAgropyron repens and Crataegus monogyna Species. . 2020; 98 - 105. 10.26650/EurJBiol.2020.0077
IEEE	Deveci E,ÇAYAN G,KARAKURT S,DURU M "Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities ofAgropyron repens and Crataegus monogyna Species." , ss.98 - 105, 2020. 10.26650/EurJBiol.2020.0077
ISNAD	Deveci, Ebru vd. "Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities ofAgropyron repens and Crataegus monogyna Species". (2020), 98-105. https://doi.org/10.26650/EurJBiol.2020.0077

APA	Deveci E, ÇAYAN G, KARAKURT S, DURU M (2020). Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities ofAgropyron repens and Crataegus monogyna Species. European Journal of Biology, 79(2), 98 - 105. 10.26650/EurJBiol.2020.0077
Chicago	Deveci Ebru,ÇAYAN Gülşen TEL,KARAKURT Serdar,DURU Mehmet Emin Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities ofAgropyron repens and Crataegus monogyna Species. European Journal of Biology 79, no.2 (2020): 98 - 105. 10.26650/EurJBiol.2020.0077
MLA	Deveci Ebru,ÇAYAN Gülşen TEL,KARAKURT Serdar,DURU Mehmet Emin Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities ofAgropyron repens and Crataegus monogyna Species. European Journal of Biology, vol.79, no.2, 2020, ss.98 - 105. 10.26650/EurJBiol.2020.0077
AMA	Deveci E,ÇAYAN G,KARAKURT S,DURU M Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities ofAgropyron repens and Crataegus monogyna Species. European Journal of Biology. 2020; 79(2): 98 - 105. 10.26650/EurJBiol.2020.0077
Vancouver	Deveci E,ÇAYAN G,KARAKURT S,DURU M Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities ofAgropyron repens and Crataegus monogyna Species. European Journal of Biology. 2020; 79(2): 98 - 105. 10.26650/EurJBiol.2020.0077
IEEE	Deveci E,ÇAYAN G,KARAKURT S,DURU M "Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities ofAgropyron repens and Crataegus monogyna Species." European Journal of Biology, 79, ss.98 - 105, 2020. 10.26650/EurJBiol.2020.0077
ISNAD	Deveci, Ebru vd. "Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities ofAgropyron repens and Crataegus monogyna Species". European Journal of Biology 79/2 (2020), 98-105. https://doi.org/10.26650/EurJBiol.2020.0077