Protective Eff ects of Chrysin in Rats with Ovarian Torsion
Yıl: 2021 Cilt: 27 Sayı: 4 Sayfa Aralığı: 417 - 424 Metin Dili: İngilizce DOI: 10.9775/kvfd.2021.25357 İndeks Tarihi: 22-11-2021
Protective Eff ects of Chrysin in Rats with Ovarian Torsion
Öz: The objective of this study is to assess the protective eff ect of chrysin (CH) against ovarian torsion-detorsion injury. Thirty-two female albino ratswere divided into 4 groups as Control, Torsion/Detorsion (T/D), TD-CH, and CH. Ovarian torsion was done for 3 hours on TD and TD-CH groupsand then detorsion was performed. 50 mg/kg of CH was administered to the TD-CH group via oral gavage half an hour before the detorsion.Subsequently, 50 mg/kg of CH was administered via oral gavage to TD-CH and CH groups for 14 days. At the end of the experiment, bloodsamples were collected and ovarian tissue were taken. SOD and GPx activities and GSH and 8-OHdG levels were studied in serum and ovariantissue. Also, IL-18, KIM-1, NGAL, Cys-C levels were studied in serum samples. GSH levels and GPx, SOD activities in both serum and ovarian tissuewere significantly lower in TD group compared to the control and TD-CH groups (P<0.05), whereas the 8-OHdG level was significantly higher(P<0.05). Treatment with CH resulted in a decrease in 8-OHdG level and an increase in GSH level, GPx and SOD activities in both serum andovarian tissue in the TD-CH group compared to TD group (P<0.05). Chrysin could ameliorate ovarian injury. Essentially, this outcome is thanks tothe antioxidant, anti-infl ammatory, and antiapoptotic eff ects of chrysin. Furthermore, it also has significant eff ects on DNA oxidative damage.
Anahtar Kelime: Ovaryum Torsiyonu Uygulanmış Ratlarda Chrisinin Koruyucu Etkisi
Öz: Bu çalışmadaki amacımız ovaryum torsiyon detorsiyon hasarına karşı chrysinin (CH) koruyucu etkisini değerlendirmektir. Otuz iki adet dişi wistar albino rat 4 gruba ayrıldı. Grup 1. Kontrol grubu, grup 2: TD grubu; grup 3: TD-CH grubu; grup 4: CH grubu. TD ve TD- CH gruplarına 3 saat torsiyon uygulandı ve 3 saatin sonunda detorsiyon yapıldı. TD-CH grubuna detorsiyondan yarım saat önce 50 mg/kg CH oral gavaj ile verildi. Daha sonra TD-CH ve CH gruplarına 14 gün boyunca 50 mg/kg CH oral gavaj ile verildi. Deneme sonunda ratlar sakrifiye edilerek kan örnekleri ve ovaryum dokusu alındı. Serum ve ovaryum dokusunda SOD ve GPx aktiviteleri, GSH ve 8-OHdG seviyeleri, serum örneklerinde ise 8-OHdG, IL-18, KIM-1, NGAL, Cys-C seviyeleri çalışıldı. TD grubunda hem serum hem de ovaryum dokusunda, GSH seviyeleri, GPx ve SOD aktiviteleri kontrol ve TD-CH gruplarından anlamlı olarak düşükken (P<0.05), 8-OHdG seviyesi anlamlı olarak yüksekti (P<0.05). TD-CH grubunda, CH uygulaması TD grubu ile karşılaştırıldığında hem serum hem de ovaryum dokusunda 8-OHdG seviyesini anlamlı olarak düşürürken, GSH seviyesi, GPx ve SOD aktivitelerini anlamlı olarak arttırmıştır (P<0.05). Chrysin ovaryum hasarını düzeltebilir. Bu sonuç esas olarak chrysinin antioksidant, antiinfl ammatuvar ve antiapoptotik etkilerinden kaynaklanmaktadır. Dahası DNA hasarı üzerinde de önemli etkileri vardır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Dirik D, kömüroğlu a, KOŞAL V, BAŞBUĞAN Y, özdek u, Kolusarı P, KELES O (2021). Protective Eff ects of Chrysin in Rats with Ovarian Torsion. , 417 - 424. 10.9775/kvfd.2021.25357 |
| Chicago | Dirik Deniz,kömüroğlu ahmet ufuk,KOŞAL Volkan,BAŞBUĞAN Yıldıray,özdek uğur,Kolusarı Pınar,KELES OMER FARUK Protective Eff ects of Chrysin in Rats with Ovarian Torsion. (2021): 417 - 424. 10.9775/kvfd.2021.25357 |
| MLA | Dirik Deniz,kömüroğlu ahmet ufuk,KOŞAL Volkan,BAŞBUĞAN Yıldıray,özdek uğur,Kolusarı Pınar,KELES OMER FARUK Protective Eff ects of Chrysin in Rats with Ovarian Torsion. , 2021, ss.417 - 424. 10.9775/kvfd.2021.25357 |
| AMA | Dirik D,kömüroğlu a,KOŞAL V,BAŞBUĞAN Y,özdek u,Kolusarı P,KELES O Protective Eff ects of Chrysin in Rats with Ovarian Torsion. . 2021; 417 - 424. 10.9775/kvfd.2021.25357 |
| Vancouver | Dirik D,kömüroğlu a,KOŞAL V,BAŞBUĞAN Y,özdek u,Kolusarı P,KELES O Protective Eff ects of Chrysin in Rats with Ovarian Torsion. . 2021; 417 - 424. 10.9775/kvfd.2021.25357 |
| IEEE | Dirik D,kömüroğlu a,KOŞAL V,BAŞBUĞAN Y,özdek u,Kolusarı P,KELES O "Protective Eff ects of Chrysin in Rats with Ovarian Torsion." , ss.417 - 424, 2021. 10.9775/kvfd.2021.25357 |
| ISNAD | Dirik, Deniz vd. "Protective Eff ects of Chrysin in Rats with Ovarian Torsion". (2021), 417-424. https://doi.org/10.9775/kvfd.2021.25357 |
| APA | Dirik D, kömüroğlu a, KOŞAL V, BAŞBUĞAN Y, özdek u, Kolusarı P, KELES O (2021). Protective Eff ects of Chrysin in Rats with Ovarian Torsion. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 27(4), 417 - 424. 10.9775/kvfd.2021.25357 |
| Chicago | Dirik Deniz,kömüroğlu ahmet ufuk,KOŞAL Volkan,BAŞBUĞAN Yıldıray,özdek uğur,Kolusarı Pınar,KELES OMER FARUK Protective Eff ects of Chrysin in Rats with Ovarian Torsion. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 27, no.4 (2021): 417 - 424. 10.9775/kvfd.2021.25357 |
| MLA | Dirik Deniz,kömüroğlu ahmet ufuk,KOŞAL Volkan,BAŞBUĞAN Yıldıray,özdek uğur,Kolusarı Pınar,KELES OMER FARUK Protective Eff ects of Chrysin in Rats with Ovarian Torsion. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, vol.27, no.4, 2021, ss.417 - 424. 10.9775/kvfd.2021.25357 |
| AMA | Dirik D,kömüroğlu a,KOŞAL V,BAŞBUĞAN Y,özdek u,Kolusarı P,KELES O Protective Eff ects of Chrysin in Rats with Ovarian Torsion. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2021; 27(4): 417 - 424. 10.9775/kvfd.2021.25357 |
| Vancouver | Dirik D,kömüroğlu a,KOŞAL V,BAŞBUĞAN Y,özdek u,Kolusarı P,KELES O Protective Eff ects of Chrysin in Rats with Ovarian Torsion. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2021; 27(4): 417 - 424. 10.9775/kvfd.2021.25357 |
| IEEE | Dirik D,kömüroğlu a,KOŞAL V,BAŞBUĞAN Y,özdek u,Kolusarı P,KELES O "Protective Eff ects of Chrysin in Rats with Ovarian Torsion." Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 27, ss.417 - 424, 2021. 10.9775/kvfd.2021.25357 |
| ISNAD | Dirik, Deniz vd. "Protective Eff ects of Chrysin in Rats with Ovarian Torsion". Kafkas Üniversitesi Veteriner Fakültesi Dergisi 27/4 (2021), 417-424. https://doi.org/10.9775/kvfd.2021.25357 |
