TY  - JOUR
TI  - Protective Eff ects of Chrysin in Rats with Ovarian Torsion
AB  - The objective of this study is to assess the protective eff ect of chrysin (CH) against ovarian torsion-detorsion injury. Thirty-two female albino ratswere divided into 4 groups as Control, Torsion/Detorsion (T/D), TD-CH, and CH. Ovarian torsion was done for 3 hours on TD and TD-CH groupsand then detorsion was performed. 50 mg/kg of CH was administered to the TD-CH group via oral gavage half an hour before the detorsion.Subsequently, 50 mg/kg of CH was administered via oral gavage to TD-CH and CH groups for 14 days. At the end of the experiment, bloodsamples were collected and ovarian tissue were taken. SOD and GPx activities and GSH and 8-OHdG levels were studied in serum and ovariantissue. Also, IL-18, KIM-1, NGAL, Cys-C levels were studied in serum samples. GSH levels and GPx, SOD activities in both serum and ovarian tissuewere significantly lower in TD group compared to the control and TD-CH groups (P<0.05), whereas the 8-OHdG level was significantly higher(P<0.05). Treatment with CH resulted in a decrease in 8-OHdG level and an increase in GSH level, GPx and SOD activities in both serum andovarian tissue in the TD-CH group compared to TD group (P<0.05). Chrysin could ameliorate ovarian injury. Essentially, this outcome is thanks tothe antioxidant, anti-infl ammatory, and antiapoptotic eff ects of chrysin. Furthermore, it also has significant eff ects on DNA oxidative damage.
AU  - KELES, OMER FARUK
AU  - Dirik, Deniz
AU  - kömüroğlu, ahmet ufuk
AU  - özdek, uğur
AU  - BAŞBUĞAN, Yıldıray
AU  - KOŞAL, Volkan
AU  - Kolusarı, Pınar
DO  - 10.9775/kvfd.2021.25357
PY  - 2021
JO  - Kafkas Üniversitesi Veteriner Fakültesi Dergisi
VL  - 27
IS  - 4
SN  - 1300-6045
SP  - 417
EP  - 424
DB  - TRDizin
UR  - http://search/yayin/detay/462574
ER  -