TY  - JOUR
TI  - Presence and Importance of Oxidative Stress Parameters in Malignant Mammary Gland Tumors in Dogs
AB  - This study aimed to evaluate the presence of oxidative stress based on lipid peroxidation and the DNA damage markers malondialdehyde (MDA) and 8-hydroxy-2’-deoxyguanosine (8-OHdG) in canine mammary gland carcinomas using immunohistochemistry techniques. A total of ten malignant and six normal canine mammary tissue samples were evaluated. The specimens were fixed in 10% buff ered formaldehyde solution, processed routinely, embedded in paraffin wax, sectioned at 5 μm, stained with hematoxylin and eosin, examined under a light microscope, and photographed to detect histopathological changes. For immunohistochemistry, the avidin-biotin-peroxidase method was performed. All canine mammary gland tumors were immunopositive for MDA and 8-OHdG expression. There was a statistically significant increase in MDA and 8-OHdG expressions in the tumor group compared to the control group. Based on this study data, in the context of oxidative stress, it is proposed that lipid peroxidation and reactive oxygen species (ROS)-induced DNA damage are significantly associated with canine mammary gland tumor development. In addition, antioxidants may be useful in the treatment of canine mammary gland tumors.
AU  - NUHOĞLU, HİLMİ
AU  - YILDIZ, Ayfer
AU  - DAĞ, SERPİL
AU  - Oral, Hasan
AU  - Karakurt, Emin
AU  - KURU, Mushap
AU  - BEYTUT, ENVER
DO  - 10.9775/kvfd.2021.25919
PY  - 2021
JO  - Kafkas Üniversitesi Veteriner Fakültesi Dergisi
VL  - 27
IS  - 4
SN  - 1300-6045
SP  - 517
EP  - 523
DB  - TRDizin
UR  - http://search/yayin/detay/462938
ER  -