Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS

Goren, Ahmet C; Gulcin, ilhami; KIZILTAŞ, Hatice; BİNGÖL, Zeynebe; ALWASEL, Saleh H.

Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS

Hatice Kızıltaş, (Sağlık Hizmetleri Meslek Yüksekokulu, Van Yüzüncü Yıl Üniversitesi, 65080-Van, Türkiye)

Ahmet C. Gören, (Bezmialem Vakıf Üniversitesi Eczacılık Fakültesi Analitik Kimya Anabilim Dalı, 34093-İstanbul, Türkiye)

Zeynebe Bingöl, (Sağlık Hizmetleri Meslek Yüksekokulu, Tokat Gaziosmanpaşa Üniversitesi, 65080-Van, Türkiye)

Saleh H. Alwasel, (Zooloji Bölümü, Fen Fakültesi, King Saud Üniversitesi, Riyad, Suudi Arabistan)

İlhami Gülçin (Atatürk Üniversitesi Fen Fakültesi Kimya Bölümü, 25240-Erzurum, Türkiye)

Records of Natural Products

10 1

Yıl: 2021 Cilt: 15 Sayı: 6 Sayfa Aralığı: 513 - 528 Metin Dili: İngilizce İndeks Tarihi: 24-11-2021

Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS

Öz:

To evaluate the antioxidant activity of evaporated ethanolic extract of Ferula orientalis L. (EEFO) and lyophilized water extract of Ferula orientalis L. (WEFO) several in vitro antioxidant methods such as ABTS•+ scavenging activity, DPPH· scavenging activity, Fe3+reduction method, cupric ions (Cu2+) reduction capacity, and metal ion (Fe2+)-binding activities using ferrozine reagent were separately performed. Also, BHT, α-tocopherol and ascorbic acid were used as the standard antioxidant molecules. Moreover, some phenolic compounds that are responsible for antioxidant abilities of EEFO and WEFO were determined by LC-HRMS. EEFO and WEFO demonstrated effective antioxidant abilities when compared with the standards. EEFO demonstrated IC50 values of 1.946 µg/mL against acetylcholinesterase (AChE), 0.815 µg/mL against α-glycosidase, and 0.675 µg/mL against α-amylase

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KIZILTAŞ H, Goren A, BİNGÖL Z, ALWASEL S, Gulcin i (2021). Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS. , 513 - 528.
Chicago	KIZILTAŞ Hatice,Goren Ahmet C,BİNGÖL Zeynebe,ALWASEL Saleh H.,Gulcin ilhami Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS. (2021): 513 - 528.
MLA	KIZILTAŞ Hatice,Goren Ahmet C,BİNGÖL Zeynebe,ALWASEL Saleh H.,Gulcin ilhami Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS. , 2021, ss.513 - 528.
AMA	KIZILTAŞ H,Goren A,BİNGÖL Z,ALWASEL S,Gulcin i Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS. . 2021; 513 - 528.
Vancouver	KIZILTAŞ H,Goren A,BİNGÖL Z,ALWASEL S,Gulcin i Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS. . 2021; 513 - 528.
IEEE	KIZILTAŞ H,Goren A,BİNGÖL Z,ALWASEL S,Gulcin i "Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS." , ss.513 - 528, 2021.
ISNAD	KIZILTAŞ, Hatice vd. "Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS". (2021), 513-528.

APA	KIZILTAŞ H, Goren A, BİNGÖL Z, ALWASEL S, Gulcin i (2021). Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS. Records of Natural Products, 15(6), 513 - 528.
Chicago	KIZILTAŞ Hatice,Goren Ahmet C,BİNGÖL Zeynebe,ALWASEL Saleh H.,Gulcin ilhami Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS. Records of Natural Products 15, no.6 (2021): 513 - 528.
MLA	KIZILTAŞ Hatice,Goren Ahmet C,BİNGÖL Zeynebe,ALWASEL Saleh H.,Gulcin ilhami Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS. Records of Natural Products, vol.15, no.6, 2021, ss.513 - 528.
AMA	KIZILTAŞ H,Goren A,BİNGÖL Z,ALWASEL S,Gulcin i Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS. Records of Natural Products. 2021; 15(6): 513 - 528.
Vancouver	KIZILTAŞ H,Goren A,BİNGÖL Z,ALWASEL S,Gulcin i Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS. Records of Natural Products. 2021; 15(6): 513 - 528.
IEEE	KIZILTAŞ H,Goren A,BİNGÖL Z,ALWASEL S,Gulcin i "Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS." Records of Natural Products, 15, ss.513 - 528, 2021.
ISNAD	KIZILTAŞ, Hatice vd. "Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS". Records of Natural Products 15/6 (2021), 513-528.