Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment
Yıl: 2020 Cilt: 13 Sayı: 3 Sayfa Aralığı: 569 - 578 Metin Dili: İngilizce DOI: 10.31362/patd.691645 İndeks Tarihi: 02-12-2021
Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment
Öz: Purpose: The Hepatitis B surface antigen (HBsAg) test was only used for diagnosis of hepatitis B infection, whereas now there is growing evidence favoring utilization of serum HBsAg quantitation (qHBsAg) for monitoring of infection with hepatitis B virus (HBV). In our study, we examined the courses of qHBsAg and HBV-DNA levels throughout the treatment course of patients receiving treatment for chronic hepatitis B infection and evaluated their correlation with each other. Material and methods: The study was performed Ankara Training and Research Hospital. A total of 71 patients receiving treatment for the diagnosis of chronic hepatitis B (CHB) infection were included in the study. Serum qHBsAg levels of these patients were analyzed with an Elecsys HBsAg II assay. Results: When we evaluated the correlation of serum qHBsAg levels with the HBV-DNA levels among patients treated with nucleotide analogues, there was a positive correlation. The decline in both parameters at sixth and 12-month follow-up was found to be statistically significant (qHBsAg decline at 6th month: p=0.03; qHBsAg decline at 12th month: p=0.001; HBV-DNA decline at 6th month: p=0.001; HBV-DNA decline at12th month: p=0.001). In the group of patients receiving PEG-IFN treatment, there was positive correlation between the two at the end of the treatment (p=0.01). Conclusion: : Our findings suggest that qHBsAg can be a very useful test when hbv-DNA levels are used together to separate inactive HBsAg carriers and KHB patients and may be used for both the treatment decision and monitoring of treatment.
Anahtar Kelime: Tedavi alan kronik hepatit B hastalarında serum kantitatif HBsAg düzeyi ile viral yük arasındaki ilişkinin araştırılması
Öz: Amaç: Yakın geçmişe kadar HBsAg sadece hepatit B enfeksiyonun tanısında kullanılırken, günümüzde serum HBsAg kantitasyonu (qHBsAg)’nun, hepatit B virüsü (HBV) enfeksiyonunun viral monitörizasyonunda kullanılabileceğine dair veriler artmaya başlamıştır. Bu çalışmada inaktif hepatit B taşıyıcıları ile kronik aktif hepatit B hastaları arasındaki qHBsAg ile HBV DNA düzeyleri karşılaştırılmış ve tedavi başlanmış hastalarda tedavi süresince qHBsAg ile HBVDNA seyri izlenerek aralarındaki ilişki değerlendirilmiştir. Gereç ve yöntem: Çalışma Ankara Eğitim ve Araştırma Hastanesi Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği’nde yapılmıştır. Kronik hepatit B (KHB) tanısıyla tedavi alan 71 hasta ve inaktif HBsAg taşıyıcısı 74 hasta çalışmaya dahil edildi. Bu hastalarda serum qHBsAg düzeyleri Elecsys HBsAg II cihazı ile çalışıldı. Bulgular: Nükleoz(t)id analoğu ile tedavi edilen hastalarda 6. ve 12. aydaki serum qHBsAg düzeyi ile HBVDNA arasında pozitif yönde bir korelasyon görüldü ve her iki parametrenin altı ay ve bir yıllık izlemindeki düşüş istatiksel olarak anlamlı bulundu (qHBsAg 6ay p=0,03, qHBsAg 12 ay p=0,001, HBV DNA 6 ay p=0,001, HBV DNA 12 ay p=0,001). Peg-IFN tedavisi alan kronik hepatit B hastalarında ise serum qHBsAg düzeyi ile HBVDNA arasında tedavi başlangıcı ve 6. ayında anlamlı bir ilişki olmayıp tedavi sonunda pozitif yönde korelasyon görüldü. PEG-IFN tedavisi alan hasta grubunda ise qHBsAg seviyeleri ile HBV DNA arasındaki korelasyon tedavi sonunda anlamlı (p=0,01) olarak saptandı.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | DEMİRELLİ M, Tulek N, Temoçin F, Yucel D, ERDINC F, Tuncer Ertem G (2020). Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment. , 569 - 578. 10.31362/patd.691645 |
| Chicago | DEMİRELLİ MERYEM,Tulek Necla,Temoçin Fatih,Yucel Dogan,ERDINC Fatma Sebnem,Tuncer Ertem Gunay Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment. (2020): 569 - 578. 10.31362/patd.691645 |
| MLA | DEMİRELLİ MERYEM,Tulek Necla,Temoçin Fatih,Yucel Dogan,ERDINC Fatma Sebnem,Tuncer Ertem Gunay Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment. , 2020, ss.569 - 578. 10.31362/patd.691645 |
| AMA | DEMİRELLİ M,Tulek N,Temoçin F,Yucel D,ERDINC F,Tuncer Ertem G Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment. . 2020; 569 - 578. 10.31362/patd.691645 |
| Vancouver | DEMİRELLİ M,Tulek N,Temoçin F,Yucel D,ERDINC F,Tuncer Ertem G Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment. . 2020; 569 - 578. 10.31362/patd.691645 |
| IEEE | DEMİRELLİ M,Tulek N,Temoçin F,Yucel D,ERDINC F,Tuncer Ertem G "Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment." , ss.569 - 578, 2020. 10.31362/patd.691645 |
| ISNAD | DEMİRELLİ, MERYEM vd. "Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment". (2020), 569-578. https://doi.org/10.31362/patd.691645 |
| APA | DEMİRELLİ M, Tulek N, Temoçin F, Yucel D, ERDINC F, Tuncer Ertem G (2020). Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment. Pamukkale Tıp Dergisi, 13(3), 569 - 578. 10.31362/patd.691645 |
| Chicago | DEMİRELLİ MERYEM,Tulek Necla,Temoçin Fatih,Yucel Dogan,ERDINC Fatma Sebnem,Tuncer Ertem Gunay Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment. Pamukkale Tıp Dergisi 13, no.3 (2020): 569 - 578. 10.31362/patd.691645 |
| MLA | DEMİRELLİ MERYEM,Tulek Necla,Temoçin Fatih,Yucel Dogan,ERDINC Fatma Sebnem,Tuncer Ertem Gunay Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment. Pamukkale Tıp Dergisi, vol.13, no.3, 2020, ss.569 - 578. 10.31362/patd.691645 |
| AMA | DEMİRELLİ M,Tulek N,Temoçin F,Yucel D,ERDINC F,Tuncer Ertem G Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment. Pamukkale Tıp Dergisi. 2020; 13(3): 569 - 578. 10.31362/patd.691645 |
| Vancouver | DEMİRELLİ M,Tulek N,Temoçin F,Yucel D,ERDINC F,Tuncer Ertem G Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment. Pamukkale Tıp Dergisi. 2020; 13(3): 569 - 578. 10.31362/patd.691645 |
| IEEE | DEMİRELLİ M,Tulek N,Temoçin F,Yucel D,ERDINC F,Tuncer Ertem G "Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment." Pamukkale Tıp Dergisi, 13, ss.569 - 578, 2020. 10.31362/patd.691645 |
| ISNAD | DEMİRELLİ, MERYEM vd. "Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment". Pamukkale Tıp Dergisi 13/3 (2020), 569-578. https://doi.org/10.31362/patd.691645 |
