TY  - JOUR
TI  - Low-dose vancomycin-loaded cement spacer for two-stage revision of infected total hip arthroplasty
AB  - Objectives: This study aims to evaluate the success rate in terms of eradication of infection and long-term outcomes of twostage revision arthroplasty with spacers loaded with low-dose vancomycin alone for the treatment of an infected hip arthroplasty. Patients and methods: The records of 42 two-stage exchange arthroplasty patients (16 males, 26 females; mean age 61 years; range, 30 to 80 years) treated between January 1999 and January 2009 were included in this retrospective study. In the first stage, following removal of the prosthesis and debridement, a spacer consisting of 1 g of vancomycin per 40 g of cement was placed in the infected joint space. Patients received six weeks of intravenous antibiotics according to intraoperative cultures. After cessation of systemic antibiotic treatment, with normal C-reactive protein and erythrocyte sedimentation rate levels, second stage surgery with cementless components was performed. Results: The mean follow-up duration was seven (range, 3 to 13) years. Two patients (4.7%) developed re-infection after two-stage reimplantation and one patient underwent a resection arthroplasty after repeated debridements. Five years of survival was 92.9% with Kaplan-Meier survival analysis. Conclusion: For chronic infected total hip revisions, two-stage revision arthroplasty with low-dose vancomycin impregnated cement spacers have comparable re-infection and success rates. Low-dose vancomycin promotes effective infection control and reduces antibiotic toxicity.
AU  - Akgun, Rahmi Can
AU  - Caglar, Omur
AU  - ATILLA, BULENT
AU  - TOKGOZOGLU, AHMET MAZHAR
DO  - 10.5606/ehc.2020.76108
PY  - 2020
JO  - Joint diseases and related surgery
VL  - 31
IS  - 3
SN  - 2687-4784
SP  - 449
EP  - 455
DB  - TRDizin
UR  - http://search/yayin/detay/466294
ER  -