TY  - JOUR
TI  - Effects of Exercise and Calorie Restriction on Brain and Testis in Natural Aging Model
AB  - The aim of our study was to examine the effects of exercise and calorie restriction on various tissue damage and antioxidant parameters in the brain and testis of rats in a natural aging model. For this purpose, male Sprague-Dawley rats were the control group (C), the elderly (A), the elderly with calorie restriction (ACR), the elderly who were exercised (AE) and the elderly who were exercised with calorie restriction (ACRE), they were divided into 5 groups. The control group was composed of three-month-old animals. The other group consisted of 15-month-old rats. Exercise and calorie restriction were applied for 6 weeks. At the end of the experiment, lipid peroxidation (LPO), nitric oxide (NO), glutathione (GSH) levels and superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST) and tissue factor (TF) were determined in brain and testicular tissues homogenates. As a result of the study, the A group’s brain and testis LPO, NO levels and TF activity increased, GSH levels and SOD, CAT and GST activities decreased, when compared to the C group. As a result of our study, an increase in oxidant damage was observed with TF activity in the brain and testis in the natural aging model, and positive effects of exercise and calorie restriction on the antioxidant levels in the brain were determined, especially in aging.
AU  - Ustundag, Unsal Veli
AU  - Yarat, Aysen
AU  - Tunali-Akbay, Tugba
AU  - Özçelik, Reyhan
AU  - Alev-Tuzuner, Burcin
AU  - Şener, Göksel
AU  - Emekli-Alturfan, Ebru
AU  - HAKGÜDER, Umay
AU  - İpekçi, Hazal
AU  - Kahraman, Nevin Genc
DO  - 10.26650/experimed.2021.899430
PY  - 2021
JO  - EXPERIMED
VL  - 11
IS  - 1
SN  - 2630-6050
SP  - 21
EP  - 26
DB  - TRDizin
UR  - http://search/yayin/detay/466354
ER  -