Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers
Yıl: 2021 Cilt: 11 Sayı: 1 Sayfa Aralığı: 27 - 32 Metin Dili: İngilizce DOI: 10.26650/experimed.2021.879204 İndeks Tarihi: 03-12-2021
Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers
Öz: Objective: Diabetes mellitus is a metabolic disease of global importance. It affects many people by reducing their quality of life and even causing death. Therefore, research on diabetes mellitus maintains its popularity and continues to develop. Chard (Beta vulgaris L. var. cicla) is commonly used in diets and is known to have alternative hypoglycemic effects in diabetic individuals. This study investigated the protective effects of chard on glycoproteins (hexose, hexosamine, fucose and sialic acid) and the advanced oxidation protein product levels in diabetic rats’ livers. Materials and Methods: For this experiment, male Sprague–Dawley rats were separated into three groups: the control; Streptozotocin (STZ)-induced diabetic rats; and STZ-induced diabetic + chard extract. Fourteen days after diabetes induction, chard extract (2 g/kg/day, gavage) was administered for 45 days. On day 60, liver samples were collected, and 10% (w/v) homogenate was prepared for the analysis of glycoprotein components and advanced oxidation protein products. Results: Levels of glycoprotein parameters that include hexose, hexosamine, fucose, and sialic acid, as well as advanced oxidation protein product levels, increased in the diabetic group. Chard extract administration curatively reverted the altered biochemical parameters. Conclusion: From the results obtained, it can be suggested that chard extract has a protective effect on the diabetic livers of rats.
Anahtar Kelime: Diyabetik Sıçan Karaciğerinde Pazı Ekstresinin Glikoprotein Bileşikleri ve İleri Oksidasyon Protein Ürün Seviyeleri Üzerindeki Koruyucu Etkisi
Öz: Amaç: Diyabet, yaşam kalitesini düşüren ve hatta ölüme neden olan, tüm dünyada birçok insanı etkileyen metabolik bir hastalıktır. Bu yüzden diyabet üzerine yapılan araştırmalar popülerliğini korumakta ve gelişimini devam ettirmektedir. Pazı (Beta vulgaris L. var. cicla) Türkiye'de şeker hastalarının alternatif hipoglisemik ajan olarak kullandığı bir bitkidir. Bu çalışmada pazı ekstraktının, diyabetik sıçanların karaciğer dokusunda bulunan glikoproteinler (heksoz, heksozamin, fukoz ve siyalik asit) ve ileri oksidasyon protein ürün seviyeleri üzerindeki koruyucu etkisinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Deneyde kullanılan erkek Sprague-Dawley sıçanları 3 gruba ayrıldı. Kontrol sıçanları; Streptozotosin (STZ) ile diyabetik yapılan sıçanlar; pazı ekstresi verilen STZ diyabetik sıçanlar; Sıçanların diyabet olmasından on dört gün sonra, sıçanlara pazı ekstresi (2 g/kg/gün, gavaj ile) belirtilen dozda 45 gün uygulandı. 60. günde sıçan karaciğerleri çıkarıldı ve glikoproteinler ve ileri oksidasyon protein ürünlerinin analizi için %10 (w/v) karaciğer homojenizatları hazırlandı. Bulgular: Yapılan deneyler sonucunda diyabetik sıçanların glikoprotein parametreleri olan heksoz, heksozamin, fukoz, siyalik asit ve ileri oksidasyon protein ürün seviyelerinin arttığı bulunmuştur. Pazı ekstresinin uygulaması, incelenen biyokimyasal parametre değerlerinin tersine çevirdiği belirlenmiştir. Sonuç: Elde edilen sonuçlardan pazı ektresinin diyabetik sıçanlar üzerinde koruyucu bir etkiye sahip olduğu ileri sürülebilir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | ERTİK O, SAÇAN O, YANARDAG R, KABASAKAL L, Şener G (2021). Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers. , 27 - 32. 10.26650/experimed.2021.879204 |
| Chicago | ERTİK Onur,SAÇAN OZLEM,YANARDAG REFIYE,KABASAKAL LEVENT,Şener Göksel Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers. (2021): 27 - 32. 10.26650/experimed.2021.879204 |
| MLA | ERTİK Onur,SAÇAN OZLEM,YANARDAG REFIYE,KABASAKAL LEVENT,Şener Göksel Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers. , 2021, ss.27 - 32. 10.26650/experimed.2021.879204 |
| AMA | ERTİK O,SAÇAN O,YANARDAG R,KABASAKAL L,Şener G Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers. . 2021; 27 - 32. 10.26650/experimed.2021.879204 |
| Vancouver | ERTİK O,SAÇAN O,YANARDAG R,KABASAKAL L,Şener G Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers. . 2021; 27 - 32. 10.26650/experimed.2021.879204 |
| IEEE | ERTİK O,SAÇAN O,YANARDAG R,KABASAKAL L,Şener G "Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers." , ss.27 - 32, 2021. 10.26650/experimed.2021.879204 |
| ISNAD | ERTİK, Onur vd. "Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers". (2021), 27-32. https://doi.org/10.26650/experimed.2021.879204 |
| APA | ERTİK O, SAÇAN O, YANARDAG R, KABASAKAL L, Şener G (2021). Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers. EXPERIMED, 11(1), 27 - 32. 10.26650/experimed.2021.879204 |
| Chicago | ERTİK Onur,SAÇAN OZLEM,YANARDAG REFIYE,KABASAKAL LEVENT,Şener Göksel Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers. EXPERIMED 11, no.1 (2021): 27 - 32. 10.26650/experimed.2021.879204 |
| MLA | ERTİK Onur,SAÇAN OZLEM,YANARDAG REFIYE,KABASAKAL LEVENT,Şener Göksel Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers. EXPERIMED, vol.11, no.1, 2021, ss.27 - 32. 10.26650/experimed.2021.879204 |
| AMA | ERTİK O,SAÇAN O,YANARDAG R,KABASAKAL L,Şener G Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers. EXPERIMED. 2021; 11(1): 27 - 32. 10.26650/experimed.2021.879204 |
| Vancouver | ERTİK O,SAÇAN O,YANARDAG R,KABASAKAL L,Şener G Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers. EXPERIMED. 2021; 11(1): 27 - 32. 10.26650/experimed.2021.879204 |
| IEEE | ERTİK O,SAÇAN O,YANARDAG R,KABASAKAL L,Şener G "Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers." EXPERIMED, 11, ss.27 - 32, 2021. 10.26650/experimed.2021.879204 |
| ISNAD | ERTİK, Onur vd. "Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers". EXPERIMED 11/1 (2021), 27-32. https://doi.org/10.26650/experimed.2021.879204 |
