Yıl: 2021 Cilt: 11 Sayı: 1 Sayfa Aralığı: 62 - 68 Metin Dili: İngilizce DOI: 10.4274/jarem.galenos.2021.3803 İndeks Tarihi: 04-12-2021

Could Chest Computed Tomography Scores Assess the Inflammatory Markers and Disease Severity of Coronavirus Disease-2019 Patients?

Öz:
Objective: This study aimed to investigate the relationship between chest computed tomography (CT) scores and inflammatory markers in patients with coronavirus disease-2019 (COVID-19). Methods: A total of 259 patients who were confirmed to be COVID-19 positive with polymerase chain reaction test and CT findings, between 20 March and 30 May 2020, were included in our study. The patients were divided into two groups as critical and moderate according to their clinical conditions. CT findings, complete blood account and C-reactive protein (CRP) were recorded and statistically analysed. Receiver operating characteristic (ROC) curves were plotted in terms of CT scores, white blood cells, neutrophil/lymphocyte ratio (NLR) and CRP for the patients in the moderate and critical groups. Results: CT scores (p<0.001), neutrophil counts (p<0.001), NLR (p<0.001) and CRP values (p<0.001) were significantly higher in the critical group than in the moderate group, whereas the lymphocyte count (p<0.001) and haemoglobin values (p=0.003) were significantly lower. In the ROC curve analysis, when the cut-off value was set at 6.5 to differentiate the moderate and critical groups, the CT score sensitivity was 0.86, specificity 0.809, area under the curve 0.899 and accuracy 0.81. Conclusion: There is a correlation between CT scores and NLR. It is crucial to differentiate patients in critical and moderate conditions for the treatment planning of COVID-19. In addition to clinical findings and inflammatory markers, radiological imaging is an effective method to identify patients and determine the prognosis.
Anahtar Kelime:

Koronavirüs Hastalığı-2019 Hastalarında Toraks Bilgisayarlı Tomografi Skoru Enflamatuvar Belirteçleri ve Hastalığın Şiddetini Yansıtabilir Mi?

Öz:
Amaç: Bizim bu çalışmadaki amacımız koronavirüs hastalığı-2019 (COVID-19) hastalarında toraks bilgisayarlı tomografi (BT) skoru ile enflamatuvar belirteçler arasındaki ilişkiyi araştırmaktı. Yöntemler: Çalışmamıza 20 Mart ve 30 Mayıs 2020 tarihleri arasında polimeraz zincir reaksiyon testi ve BT bulguları ile COVID-19 pozitif olduğu doğrulanan 259 hasta dahil edildi. Hastalar klinik durumlarına göre kritik ve orta olmak üzere iki gruba ayrıldı. Hastaların BT bulguları, tam kan sayımı ve C-reaktif protein (CRP) değerleri istatistiksel olarak analiz edildi. Orta ve kritik grup ayrımında BT skoru, beyaz küre sayısı, nötrofil/lenfosit oranı (NLO) ve CRP için ayrı ayrı alıcı işletim karakteristiği (ROC) eğrileri çizildi. Bulgular: İki grup arasındaki karşılaştırmada BT skoru (p<0,001), nötrofil sayıları (p<0,001), NLR (p<0,001) ve CRP değerleri (p<0,001) kritik grupta anlamlı olarak yüksek iken lenfosit sayısı (p<0,001) ve hemoglobin değerleri (p=0,003) anlamlı olarak düşüktü. ROC eğrisi analizinde orta ve kritikgrubu ayırt etmek için cut-off değeri 6,5 olarak alındığında BT skorunun duyarlılığı 0,86, özgüllük 0,809, eğri altındaki alan 0,899 ve doğruluğu 0,81 olarak hesaplandı. Sonuç: BT skoru ile prognotik bir belirteç olan NLO arasında korelasyon mevcuttur. COVID-19 pnömonisinde erken tedavi planlaması açısından hastaların kritik ve moderate hasta gruplarının ayrımının yapılması hasta prognozunda oldukça önemlidir. Bu ayrımı yapmada ve prognozunun belirlenmesinde, hasta klinik bulguları ve enflamatuvar belirteçlerinin yanı sıra radyolojik görüntüleme de oldukça etkin bir yöntemdir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA kayadibi y, Uçar N, Kaya M, gurkan o, namdar y, demirok b (2021). Could Chest Computed Tomography Scores Assess the Inflammatory Markers and Disease Severity of Coronavirus Disease-2019 Patients?. , 62 - 68. 10.4274/jarem.galenos.2021.3803
Chicago kayadibi yasemin,Uçar Neşe,Kaya Mehmet Fatih,gurkan okan,namdar yeşim,demirok berna Could Chest Computed Tomography Scores Assess the Inflammatory Markers and Disease Severity of Coronavirus Disease-2019 Patients?. (2021): 62 - 68. 10.4274/jarem.galenos.2021.3803
MLA kayadibi yasemin,Uçar Neşe,Kaya Mehmet Fatih,gurkan okan,namdar yeşim,demirok berna Could Chest Computed Tomography Scores Assess the Inflammatory Markers and Disease Severity of Coronavirus Disease-2019 Patients?. , 2021, ss.62 - 68. 10.4274/jarem.galenos.2021.3803
AMA kayadibi y,Uçar N,Kaya M,gurkan o,namdar y,demirok b Could Chest Computed Tomography Scores Assess the Inflammatory Markers and Disease Severity of Coronavirus Disease-2019 Patients?. . 2021; 62 - 68. 10.4274/jarem.galenos.2021.3803
Vancouver kayadibi y,Uçar N,Kaya M,gurkan o,namdar y,demirok b Could Chest Computed Tomography Scores Assess the Inflammatory Markers and Disease Severity of Coronavirus Disease-2019 Patients?. . 2021; 62 - 68. 10.4274/jarem.galenos.2021.3803
IEEE kayadibi y,Uçar N,Kaya M,gurkan o,namdar y,demirok b "Could Chest Computed Tomography Scores Assess the Inflammatory Markers and Disease Severity of Coronavirus Disease-2019 Patients?." , ss.62 - 68, 2021. 10.4274/jarem.galenos.2021.3803
ISNAD kayadibi, yasemin vd. "Could Chest Computed Tomography Scores Assess the Inflammatory Markers and Disease Severity of Coronavirus Disease-2019 Patients?". (2021), 62-68. https://doi.org/10.4274/jarem.galenos.2021.3803
APA kayadibi y, Uçar N, Kaya M, gurkan o, namdar y, demirok b (2021). Could Chest Computed Tomography Scores Assess the Inflammatory Markers and Disease Severity of Coronavirus Disease-2019 Patients?. JAREM, 11(1), 62 - 68. 10.4274/jarem.galenos.2021.3803
Chicago kayadibi yasemin,Uçar Neşe,Kaya Mehmet Fatih,gurkan okan,namdar yeşim,demirok berna Could Chest Computed Tomography Scores Assess the Inflammatory Markers and Disease Severity of Coronavirus Disease-2019 Patients?. JAREM 11, no.1 (2021): 62 - 68. 10.4274/jarem.galenos.2021.3803
MLA kayadibi yasemin,Uçar Neşe,Kaya Mehmet Fatih,gurkan okan,namdar yeşim,demirok berna Could Chest Computed Tomography Scores Assess the Inflammatory Markers and Disease Severity of Coronavirus Disease-2019 Patients?. JAREM, vol.11, no.1, 2021, ss.62 - 68. 10.4274/jarem.galenos.2021.3803
AMA kayadibi y,Uçar N,Kaya M,gurkan o,namdar y,demirok b Could Chest Computed Tomography Scores Assess the Inflammatory Markers and Disease Severity of Coronavirus Disease-2019 Patients?. JAREM. 2021; 11(1): 62 - 68. 10.4274/jarem.galenos.2021.3803
Vancouver kayadibi y,Uçar N,Kaya M,gurkan o,namdar y,demirok b Could Chest Computed Tomography Scores Assess the Inflammatory Markers and Disease Severity of Coronavirus Disease-2019 Patients?. JAREM. 2021; 11(1): 62 - 68. 10.4274/jarem.galenos.2021.3803
IEEE kayadibi y,Uçar N,Kaya M,gurkan o,namdar y,demirok b "Could Chest Computed Tomography Scores Assess the Inflammatory Markers and Disease Severity of Coronavirus Disease-2019 Patients?." JAREM, 11, ss.62 - 68, 2021. 10.4274/jarem.galenos.2021.3803
ISNAD kayadibi, yasemin vd. "Could Chest Computed Tomography Scores Assess the Inflammatory Markers and Disease Severity of Coronavirus Disease-2019 Patients?". JAREM 11/1 (2021), 62-68. https://doi.org/10.4274/jarem.galenos.2021.3803