TY  - JOUR
TI  - Chronic Effects of Ziprasidone, Aripiprazole, Blonanserin, Cyamemazine, and Nemonapride on Mice Isolated Detrusor Smooth Muscle
AB  - Objective: Ziprasidone, aripiprazole, blonanserin, cyamemazine, and nemonapride are atypical antipsychotic drugs used for the treatment of schizophrenia. This study aimed to identify the effects of these atypical antipsychotic drugs in mice isolated bladder using the organ bath system Materials and Methods: The mice were injected intraperitoneally with drugs for 21 days. The effects of drugs were investigated on isoproterenol-induced relaxation responses of carbachol-induced contractions in isolated detrusor strips. The detrusor strips were stimulated with KCl, then tissues were washed for a further 30 min and precontracted with a submaximal concentration of carbachol. After the contraction reached a plateau, cumulative concentration-response curves to isoproterenol were obtained. Results: We showed that carbachol-induced contractions dose-dependently relaxed by isoproterenol in mice detrusor strips obtained from ziprasidone, aripiprazole, blonanserin, and cyamemazine but not nemonapride treated group. However, none of the drug treatments had any effect KCl responses of mice's bladder. Conclusion: Ziprasidone, aripiprazole, blonanserin, and cyamemazine but not nemonapride increased the isoproterenol-induced relaxations of the detrusor smooth muscle indicates that it can increase the bladder capacity. We demonstrate that four drugs may represent a potential treatment for overactive bladder. They might be clinically useful for the treatment of overactive bladder in patients that should use antipsychotics.
AU  - Erden, Bekir Faruk
AU  - ulak, guner
AU  - büyükokuroğlu, mehmet emin
AU  - YILDIZ AKAR, Fürüzan
AU  - tanyeri, pelin
AU  - Mutlu, Oguz
AU  - Keles, Rumeysa
AU  - tanyeri, mehmet hanifi
AU  - Başarır Bozkurt, Şeyma Nur
DO  - 10.26453/otjhs.974323
PY  - 2021
JO  - Online Türk Sağlık Bilimleri Dergisi
VL  - 6
IS  - 4
SN  - 2459-1467
SP  - 500
EP  - 507
DB  - TRDizin
UR  - http://search/yayin/detay/467073
ER  -