Clinicopathological Features of Extranodal Lymphomas: 15Years’ Experience of a Single Center

Sinem KANTARCIOĞLU COŞKUN, (Düzce Üniversitesi, Tıp Fakültesi, Meslek Yüksekokulu, Patoloji Anabilim Dalı, Düzce, Türkiye)
Hülya ÖZTÜRK NAZLIOĞLU, (Bursa Uludağ Üniversitesi, Tıp Okulu, Patoloji Anabilim Dalı, Bursa, Türkiye)
Çağatay BÜYÜKUYSAL (Zonguldak Bülent Ecevit Üniversitesi, Tıp Fakültesi, Biyoistatistik Anabilim Dalı, Zonguldak, Türkiye)
KONURALP TIP DERGİSİ
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Yıl: 2021 Cilt: 13 Sayı: 2 Sayfa Aralığı: 226 - 232 Metin Dili: İngilizce DOI: 10.18521/ktd.789919 İndeks Tarihi: 06-12-2021

Clinicopathological Features of Extranodal Lymphomas: 15Years’ Experience of a Single Center

Öz:
Objective: In this study, we aimed to evaluate the localization and histopathologicaldiagnosis, and clinicopathologic characteristics of primary extranodal lymphomas.Methods: The pathology reports between 2001 and 2015 in the archives of UludagUniversity Faculty of Medicine Pathology Department were reviewed and all cases with anextranodal lymphoma diagnosis were analyzed. The information about the diagnosis, tumorlocalization, symptoms at presentation, presence of B symptoms, lymphocytosis and anemia,chronic infection and chronic disease and concomitant secondary malignancy, tumordiameter, the involvement of another extranodal organ, lymph node, bone marrow, spleen,liver, stage of the disease, serum B2 microglobulin, LDH, albumin levels, sedimentation ratewere documented. The localization, histopathological types, age groups, male/female ratiosin cases of primary extranodal lymphoma were evaluated.Results: Total sum of 1743 patients were diagnosed with lymphoma. 480 (%27,53) of thesecases were extranodal lymphomas. The most commonly encountered locations of extranodallymphomas were the skin and the gastrointestinal system. There were 226 primary extranodalskin, 90 gastrointestinal system, 44 central nervous system, 8 genitourinary system, 50 headand neck, 18 musculoskeletal system and soft tissue, 9 mediastinum, 3 bronchus, 10 orbital, 2liver, 6 pancreas, 4 omentum, 8 endocrine system, and 2 breast located cases. 237 of theprimary extranodal lymphomas from our work were mature T/NK celled neoplasias. Therewere 250 patients with mature B cell lymphoma, 5 cases of Hodgkin lymphoma, and 5 casesof precursor lymphoid neoplasia.Conclusions: The data from our series were coherent with the literature. Due to the smallnumber of cases with some localization and some histopathological diagnosis, no significantresults could be reached about these entities.
Anahtar Kelime:

Ekstranodal Lenfomaların Klinikopatolojik Özellikleri: 15 Yıllık Tek Merkez Deneyimi

Öz:
Amaç: Bu çalışmada 2001-2015 yılları arasında tanı alan primer ekstranodal lenfomalarınlokalizasyonlarının ve histopatolojik olarak dağılımının, klinikopatolojik özelliklerinindeğerlendirilmesi amaçlandı.Gereç ve Yöntem: Uludağ Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı arşivindeki 1Ocak 2001 ile 31 Aralık 2015 arasındaki patoloji raporları gözden geçirildi, lenfoma tanılıbütün olgular incelendi.Hasta dosyaları incelenerek primer olarak ekstranodal bölgedenkaynaklanan olguların tanısı, hastaneye başvuru semptomları, B semptomu varlığı/yokluğu,tümör çapı, başka ekstranodal organ, lenf nodu, kemik iliği, dalak, karaciğer tutulumu olupolmadığı, kronik enfeksiyon ve kronik hastalık varlığı, hastalığın evresi (Ann Arborsınıflamasına göre), eşlik eden sekonder malignite varlığı, anemi, lenfositoz varlığı, serum B2mikroglobulin, LDH, albumin değerleri, sedimentasyon hızı bilgileri dökümante edildi.Primer ekstranodal lenfomalı vakalarda belirlenen histopatolojik tanıların dağılımı, tipleri,yaş grupları, kadın/erkek oranları literatür bilgileri ışığında gözden geçirildi. Bulgular: 2001 – 2015 yılları arasında Uludağ Üniversitesi Tıp Fakültesi Tıbbi PatolojiAnabilim Dalı’nda toplam 1743 hastaya lenfoma tanısı verilmişti. Bu olguların 480 (%27,53)tanesi ekstranodal kaynaklıydı. Genel olarak en sık görülen ekstranodal lokasyon deri vegastrointestinal sistemdi. Primer ekstranodal 226 deri, 90 gastrointestinal sistem, 44 santralsinir sistemi, 8 genitoüriner sistem, 50 baş-boyun, 18 kas-iskelet-yumuşak doku, 9 mediasten,3 bronş, 10 orbita, 2 karaciğer, 6 pankreas, 4 omentum, 8 endokrin sistem, 2 meme yerleşimliolgu mevcuttu. Çalışmamızdaki primer ekstranodal lenfomaların 237’sini matür T/NKhücreli neoplaziler oluşturuyordu. Matür B hücreli lenfomalı 250 hasta mevcuttu. Hodgkinlenfoma tanılı 5, prekürsör lenfoid neoplazi tanılı 5 olgu mevcuttu.Sonuç: Sonuç olarak çalışmamızdaki veriler literatürle uyumludur. Bazı lokalizasyondaki vebazı histopatolojik tanılı olguların sayıca azlığı sebebiyle bu antiteler hakkında anlamlısonuçlara ulaşılamamıştır.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Kantarcıoğlu Coşkun S, NAZLIOĞLU H, Büyükuysal M (2021). Clinicopathological Features of Extranodal Lymphomas: 15Years’ Experience of a Single Center. , 226 - 232. 10.18521/ktd.789919
Chicago Kantarcıoğlu Coşkun Sinem,NAZLIOĞLU Hülya ÖZTÜRK,Büyükuysal Mustafa Çağatay Clinicopathological Features of Extranodal Lymphomas: 15Years’ Experience of a Single Center. (2021): 226 - 232. 10.18521/ktd.789919
MLA Kantarcıoğlu Coşkun Sinem,NAZLIOĞLU Hülya ÖZTÜRK,Büyükuysal Mustafa Çağatay Clinicopathological Features of Extranodal Lymphomas: 15Years’ Experience of a Single Center. , 2021, ss.226 - 232. 10.18521/ktd.789919
AMA Kantarcıoğlu Coşkun S,NAZLIOĞLU H,Büyükuysal M Clinicopathological Features of Extranodal Lymphomas: 15Years’ Experience of a Single Center. . 2021; 226 - 232. 10.18521/ktd.789919
Vancouver Kantarcıoğlu Coşkun S,NAZLIOĞLU H,Büyükuysal M Clinicopathological Features of Extranodal Lymphomas: 15Years’ Experience of a Single Center. . 2021; 226 - 232. 10.18521/ktd.789919
IEEE Kantarcıoğlu Coşkun S,NAZLIOĞLU H,Büyükuysal M "Clinicopathological Features of Extranodal Lymphomas: 15Years’ Experience of a Single Center." , ss.226 - 232, 2021. 10.18521/ktd.789919
ISNAD Kantarcıoğlu Coşkun, Sinem vd. "Clinicopathological Features of Extranodal Lymphomas: 15Years’ Experience of a Single Center". (2021), 226-232. https://doi.org/10.18521/ktd.789919
APA Kantarcıoğlu Coşkun S, NAZLIOĞLU H, Büyükuysal M (2021). Clinicopathological Features of Extranodal Lymphomas: 15Years’ Experience of a Single Center. KONURALP TIP DERGİSİ, 13(2), 226 - 232. 10.18521/ktd.789919
Chicago Kantarcıoğlu Coşkun Sinem,NAZLIOĞLU Hülya ÖZTÜRK,Büyükuysal Mustafa Çağatay Clinicopathological Features of Extranodal Lymphomas: 15Years’ Experience of a Single Center. KONURALP TIP DERGİSİ 13, no.2 (2021): 226 - 232. 10.18521/ktd.789919
MLA Kantarcıoğlu Coşkun Sinem,NAZLIOĞLU Hülya ÖZTÜRK,Büyükuysal Mustafa Çağatay Clinicopathological Features of Extranodal Lymphomas: 15Years’ Experience of a Single Center. KONURALP TIP DERGİSİ, vol.13, no.2, 2021, ss.226 - 232. 10.18521/ktd.789919
AMA Kantarcıoğlu Coşkun S,NAZLIOĞLU H,Büyükuysal M Clinicopathological Features of Extranodal Lymphomas: 15Years’ Experience of a Single Center. KONURALP TIP DERGİSİ. 2021; 13(2): 226 - 232. 10.18521/ktd.789919
Vancouver Kantarcıoğlu Coşkun S,NAZLIOĞLU H,Büyükuysal M Clinicopathological Features of Extranodal Lymphomas: 15Years’ Experience of a Single Center. KONURALP TIP DERGİSİ. 2021; 13(2): 226 - 232. 10.18521/ktd.789919
IEEE Kantarcıoğlu Coşkun S,NAZLIOĞLU H,Büyükuysal M "Clinicopathological Features of Extranodal Lymphomas: 15Years’ Experience of a Single Center." KONURALP TIP DERGİSİ, 13, ss.226 - 232, 2021. 10.18521/ktd.789919
ISNAD Kantarcıoğlu Coşkun, Sinem vd. "Clinicopathological Features of Extranodal Lymphomas: 15Years’ Experience of a Single Center". KONURALP TIP DERGİSİ 13/2 (2021), 226-232. https://doi.org/10.18521/ktd.789919
Sayfa Oluşturulma Tarihi
24-04-2024 18:21

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