Yıl: 2021 Cilt: 30 Sayı: 1 Sayfa Aralığı: 17 - 24 Metin Dili: İngilizce DOI: 10.5152/turkjnephrol.2021.4396

Evaluation of Thiol/Disulfide Homeostasis and Other OxidativeStress Markers in Patients Undergoing Hemodialysis

Öz:
Objective: To investigate the potential role of thiol/disulphide homeostasis as a novel biomarker of oxidative stress in pa tients with diabetes and undergoing hemodialysis (HD) and its correlation with other oxidative stress markers. Materials and Methods: This study included 82 patients with end-stage renal disease undergoing HD for four hours, threetimes weekly for more than 24 months in the dialysis center. Of the 82 patients, 47 were non-diabetic and 35 were diabet ic. Blood samples were collected from the patients before and after the HD sessions. The thiol/disulfide pair tests wereperformed and total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), ischemia-modifiedalbumin (IMA) levels, albumin levels, ceruloplasmin, catalase activity (CAT), and myeloperoxidase (MPO) activity were de termined in the serum.Results: The TAS values in all the patients, both diabetic and non-diabetic, decreased significantly after HD (p<0.001,p=0.003, and p<0.001; respectively). The TOS, albumin, native thiol (p=0.001, p=0.007, p=0.001, respectively), OSI, CAT,ceruloplasmin, IMA, MPO, and total thiol (p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, and p<0.001, respectively) valuesincreased significantly in all the patients after the HD session. The TOS, OSI, CAT, IMA, albumin, MPO, native thiol, and per centages of native/total thiol, ceruloplasmin, and total thiol values (p=0.002, p=0.002, p=0.002, p=0.001, p=0.008, p=0.001,p=0.001, p=0.003, p=0.023, and p<0.001; respectively) increased significantly in patients with diabetes after the HD session.Conclusion: In this study, we demonstrated the relationship between oxidative stress markers, which play a significant rolein the pathogenesis of diabetes, and thiol/disulfide balance undergoing HD patients.
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APA SÖĞÜT İ, ŞENAT A, İLHAN A, SEZEN A, EREL Ö (2021). Evaluation of Thiol/Disulfide Homeostasis and Other OxidativeStress Markers in Patients Undergoing Hemodialysis. Turkish journal of nephrology (Online), 30(1), 17 - 24. 10.5152/turkjnephrol.2021.4396
Chicago SÖĞÜT İbrahim,ŞENAT Almila,İLHAN Ayşegül,SEZEN Adem,EREL Özcan Evaluation of Thiol/Disulfide Homeostasis and Other OxidativeStress Markers in Patients Undergoing Hemodialysis. Turkish journal of nephrology (Online) 30, no.1 (2021): 17 - 24. 10.5152/turkjnephrol.2021.4396
MLA SÖĞÜT İbrahim,ŞENAT Almila,İLHAN Ayşegül,SEZEN Adem,EREL Özcan Evaluation of Thiol/Disulfide Homeostasis and Other OxidativeStress Markers in Patients Undergoing Hemodialysis. Turkish journal of nephrology (Online), vol.30, no.1, 2021, ss.17 - 24. 10.5152/turkjnephrol.2021.4396
AMA SÖĞÜT İ,ŞENAT A,İLHAN A,SEZEN A,EREL Ö Evaluation of Thiol/Disulfide Homeostasis and Other OxidativeStress Markers in Patients Undergoing Hemodialysis. Turkish journal of nephrology (Online). 2021; 30(1): 17 - 24. 10.5152/turkjnephrol.2021.4396
Vancouver SÖĞÜT İ,ŞENAT A,İLHAN A,SEZEN A,EREL Ö Evaluation of Thiol/Disulfide Homeostasis and Other OxidativeStress Markers in Patients Undergoing Hemodialysis. Turkish journal of nephrology (Online). 2021; 30(1): 17 - 24. 10.5152/turkjnephrol.2021.4396
IEEE SÖĞÜT İ,ŞENAT A,İLHAN A,SEZEN A,EREL Ö "Evaluation of Thiol/Disulfide Homeostasis and Other OxidativeStress Markers in Patients Undergoing Hemodialysis." Turkish journal of nephrology (Online), 30, ss.17 - 24, 2021. 10.5152/turkjnephrol.2021.4396