The Association of Serum Prolidase Enzyme Activity withthe Presence of Familial Mediterranean Fever
Yıl: 2021 Cilt: 30 Sayı: 1 Sayfa Aralığı: 37 - 42 Metin Dili: İngilizce DOI: 10.5152/turkjnephrol.2021.4421 İndeks Tarihi: 06-12-2021
The Association of Serum Prolidase Enzyme Activity withthe Presence of Familial Mediterranean Fever
Öz: Objective: Uncontrolled inflammation and oxidative stress are responsible for the pathogenesis of familial Mediterraneanfever (FMF) and its complications. Increased serum prolidase enzyme activity (SPEA) has been shown to correlate with in flammation and oxidative stress. This study aimed to evaluate the relationship between SPEA and FMF disease. Materials and Methods: A total of 124 participants were included in this cross-sectional study. Patients were divided intotwo groups depending on the presence or absence of FMF attacks. Group 1 consisted 69 patients who were attack free.Group 2 consisted of 11 patients who suffered FMF attacks. A total of 44 healthy volunteers were included in the study(Group 3). Clinical features and laboratory data were recorded. SPEA was analyzed by using spectrophotometry. Results: SPEA of Group 2 was found to be statistically significantly higher than that of Groups 1 and 3 (p=0.004 and p=0.006,respectively). SPEA was positively correlated with the presence of attack (rs =0.265, p=0.003), erythrocyte sedimentationrate (rs =0.269, p=0.003), and C-reactive protein (rs =0.199, p=0.027). The relationship between FMF attack and SPEA wasevaluated by receiver operating characteristics analysis. Sensitivity and specificity were 91% and 67%, respectively, withan SPEA cut-off point of 817 U/L (AUC=0.769 [95% CI 0.626-0.912, p=0.003]). Conclusion: The FMF attack and the associated acute phase response may have an effect on increased SPEA. In FMF pa tients, an increased SPEA may play a role in both pathogenesis and progression of complications caused by the inflamma tory process.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Diğer Erişim Türü: Erişime Açık
- 1. Ben-Chetrit E, Touitou I. Familial Mediterranean fever in the world. Arthritis Rheum 2009; 61: 1447-53. [Crossref]
- 2. Aksentijevich I, Centola M, Deng Z, Sood R, Balow JE, Wood G, et al. Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. The International FMF Consortium. Cell 1997; 90: 797-807. [Crossref]
- 3. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J, et al. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007; 39: 44-84. [Crossref]
- 4. Ediz L, Ozkol H, Tekeoglu I, Tuluce Y, Gulcu E, Koyuncu I. Increased oxidative stress in patients with familial Mediterranean fever during attack period. Afr Health Sci 2011; 11: 6-13. [Crossref]
- 5. Şahin A, Erten Ş, Altunoğlu A, Işıkoğlu S, Neşelioğlu S, Ergin M, et al. Comparison of serum oxidant and antioxidant parameters in familial Mediterranean fever patients (FMF) with attack free period. Acta Reumatol Port 2014; 39: 316-21.
- 6. Surazynski A, Miltyk W, Palka J, Phang JM. Prolidase-dependent regulation of collagen biosynthesis. Amino Acids 2008; 35: 731-8. [Crossref]
- 7. Hui KS, Lajtha A. Prolidase activity in brain: Comparison with other organs. J Neurochem 1978; 30: 321-7. [Crossref]
- 8. Hu CA, Phang J, Valle D. Proline metabolism in health and disease. Preface. Amino Acids 2008; 35: 651-2. [Crossref]
- 9. Bozkurt M, Yüksel H, Em S, Oktayoglu P, Yildiz M, Akdeniz D, et al. Serum prolidase enzyme activity and oxidative status in patients with Behçet’s disease. Redox Rep 2014; 19: 59-64. [Crossref]
- 10. Verma AK, Chandra S, Singh RG, Singh TB, Srivastava S, Srivastava R. Serum prolidase activity and oxidative stress in diabetic nephropathy and end stage renal disease: A correlative study with glucose and creatinine. Biochem Res Int 2014; 2014: 291458.[Crossref]
- 11. Livneh A, Langevitz P, Zemer D, Zaks N, Kees S, Lidar T, et al. Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum 1997; 40: 1879-85. [Crossref]
- 12. Stevens LA, Schmid CH, Greene T, Zhang YL, Beck GJ, Froissart M, et al. Comparative performance of the CKD Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) Study equations for estimating GFR levels above 60 mL/ min/1.73 m2. Am J Kidney Dis 2010; 56: 486-95. [Crossref]
- 13. Ozcan O, Gultepe M, Ipcioglu OM, Bolat B, Kayadibi H. Optimization of the photometric enzyme activity assay for evaluating real activity of prolidase. Turk J Biochem 2007; 32; 12-6.
- 14. Berkun Y, Padeh S, Reichman B, Zaks N, Rabinovich E, Lidar M, et al. A single testing of serum amyloid a levels as a tool for diagnosis and treatment dilemas in familial Mediterranean fever. Semin Arthritis Rheum 2007; 37: 182-8. [Crossref]
- 15. Apostolidou E, Skendros P, Kambas K, Mitroulis I, Konstantinidis T, Chrysanthopoulou A, et al. Neutrophil extracellular traps regulate IL-1 beta mediated inflammation in familial Mediterranean fever. Ann Rheum Dis 2016; 75: 269-77. [Crossref]
- 16. Namiduru ES. Prolidase. Bratisl Lek Listy 2016; 117: 480-5. [Crossref] 17. Bayram M, Derin ME, Doğan HO, Asan G, Şahin M, Şahin A. High prolidase levels in patients with Familial Mediterranean Fever (FMF). Rom J Intern Med 2020; 58: 27-33. [Crossref]
- 18. Simard JC, Cesaro A, Chapeton-Montes J, Tardif M, Antoine F, Girard D, et al. S100A8 and S100A9 induce cytokine expression and regulate the NLRP3 inflammasome via ROS-dependent activation of NF-κB1. PLoS One 2013; 8: e72138. [Crossref]
- 19. Clavijo-Cornejo D, Martínez-Flores K, Silva-Luna K, Martínez-Nava GA, Martínez-Nava GA, Fernández-Torres J, et al. The overexpression of NALP3 inflammasome in knee osteoarthritis ıs associated with synoal membrane prolidase and NADPH oxidase 2. Oxid Med Cell Longev 2016; 2016: 1472567. [Crossref]
- 20. Campbell L, Raheem I, Malemud CJ, Askari AD. The relationship between NALP3 and autoinflammatory syndromes. Int J Mol Sci 2016; 17: E725. [Crossref]
- 21. Surazynski A, Liu Y, Miltyk W, Phang JM. Nitric oxide regulates prolidase activity by serine/threonine phosphorylation. J Cell Biochem 2005; 96: 1086-94. [Crossref]
- 22. Gecit İ, Eryılmaz R, Kavak S, Meral İ, Demir H, Pirinççi N, et al. The prolidase activity, oxidative stress, and nitric oxide levels of bladder tissues with or without tumor in patients with bladder cancer. J Membr Biol 2017; 250: 455-9. [Crossref]
- 23. Sayın R, Aslan M, Kucukoglu ME, Luleci A, Atmaca M, Esen R, et al. Serum prolidase enzyme activity and oxidative stress levels in patients with diabetic neuropathy. Endocrine 2014; 47: 146-51. [Crossref]
- 24. Panossian A, Hambartsumyan M, Panosyan L, Abrahamyan H, Mamikonyan G, Gabrielyan E, et al. Plasma nitric oxide level in familial Mediterranean fever and its modulations by Immuno-Guard. Nitric Oxide 2003; 9: 103-10. [Crossref]
- 25. Balat A, Işlek I, Cekmen M, Yürekli M, Tekin D, Muslu A, et al. Adrenomedullin and total nitrite levels in children with familial Mediterranean fever. J Paediatr Child Health 2006; 42: 240-3. [Crossref]
- 26. Sabuncu T, Boduroglu O, Eren MA, Torun AN, Aksoy N. The value of serum prolidase activity in progression of microalbuminuria in patients with type 2 diabetes mellitus. J Clin Lab Anal 2016; 30: 557-62. [Crossref]
APA | Eser B, Dogan İ, dogan i, kayadibi h (2021). The Association of Serum Prolidase Enzyme Activity withthe Presence of Familial Mediterranean Fever. , 37 - 42. 10.5152/turkjnephrol.2021.4421 |
Chicago | Eser Baris,Dogan İsmail,dogan ibrahim,kayadibi huseyin The Association of Serum Prolidase Enzyme Activity withthe Presence of Familial Mediterranean Fever. (2021): 37 - 42. 10.5152/turkjnephrol.2021.4421 |
MLA | Eser Baris,Dogan İsmail,dogan ibrahim,kayadibi huseyin The Association of Serum Prolidase Enzyme Activity withthe Presence of Familial Mediterranean Fever. , 2021, ss.37 - 42. 10.5152/turkjnephrol.2021.4421 |
AMA | Eser B,Dogan İ,dogan i,kayadibi h The Association of Serum Prolidase Enzyme Activity withthe Presence of Familial Mediterranean Fever. . 2021; 37 - 42. 10.5152/turkjnephrol.2021.4421 |
Vancouver | Eser B,Dogan İ,dogan i,kayadibi h The Association of Serum Prolidase Enzyme Activity withthe Presence of Familial Mediterranean Fever. . 2021; 37 - 42. 10.5152/turkjnephrol.2021.4421 |
IEEE | Eser B,Dogan İ,dogan i,kayadibi h "The Association of Serum Prolidase Enzyme Activity withthe Presence of Familial Mediterranean Fever." , ss.37 - 42, 2021. 10.5152/turkjnephrol.2021.4421 |
ISNAD | Eser, Baris vd. "The Association of Serum Prolidase Enzyme Activity withthe Presence of Familial Mediterranean Fever". (2021), 37-42. https://doi.org/10.5152/turkjnephrol.2021.4421 |
APA | Eser B, Dogan İ, dogan i, kayadibi h (2021). The Association of Serum Prolidase Enzyme Activity withthe Presence of Familial Mediterranean Fever. Turkish journal of nephrology (Online), 30(1), 37 - 42. 10.5152/turkjnephrol.2021.4421 |
Chicago | Eser Baris,Dogan İsmail,dogan ibrahim,kayadibi huseyin The Association of Serum Prolidase Enzyme Activity withthe Presence of Familial Mediterranean Fever. Turkish journal of nephrology (Online) 30, no.1 (2021): 37 - 42. 10.5152/turkjnephrol.2021.4421 |
MLA | Eser Baris,Dogan İsmail,dogan ibrahim,kayadibi huseyin The Association of Serum Prolidase Enzyme Activity withthe Presence of Familial Mediterranean Fever. Turkish journal of nephrology (Online), vol.30, no.1, 2021, ss.37 - 42. 10.5152/turkjnephrol.2021.4421 |
AMA | Eser B,Dogan İ,dogan i,kayadibi h The Association of Serum Prolidase Enzyme Activity withthe Presence of Familial Mediterranean Fever. Turkish journal of nephrology (Online). 2021; 30(1): 37 - 42. 10.5152/turkjnephrol.2021.4421 |
Vancouver | Eser B,Dogan İ,dogan i,kayadibi h The Association of Serum Prolidase Enzyme Activity withthe Presence of Familial Mediterranean Fever. Turkish journal of nephrology (Online). 2021; 30(1): 37 - 42. 10.5152/turkjnephrol.2021.4421 |
IEEE | Eser B,Dogan İ,dogan i,kayadibi h "The Association of Serum Prolidase Enzyme Activity withthe Presence of Familial Mediterranean Fever." Turkish journal of nephrology (Online), 30, ss.37 - 42, 2021. 10.5152/turkjnephrol.2021.4421 |
ISNAD | Eser, Baris vd. "The Association of Serum Prolidase Enzyme Activity withthe Presence of Familial Mediterranean Fever". Turkish journal of nephrology (Online) 30/1 (2021), 37-42. https://doi.org/10.5152/turkjnephrol.2021.4421 |