TY  - JOUR
TI  - The Association of Serum Prolidase Enzyme Activity withthe Presence of Familial Mediterranean Fever
AB  - Objective: Uncontrolled inflammation and oxidative stress are responsible for the pathogenesis of familial Mediterraneanfever (FMF) and its complications. Increased serum prolidase enzyme activity (SPEA) has been shown to correlate with in flammation and oxidative stress. This study aimed to evaluate the relationship between SPEA and FMF disease. Materials and Methods: A total of 124 participants were included in this cross-sectional study. Patients were divided intotwo groups depending on the presence or absence of FMF attacks. Group 1 consisted 69 patients who were attack free.Group 2 consisted of 11 patients who suffered FMF attacks. A total of 44 healthy volunteers were included in the study(Group 3). Clinical features and laboratory data were recorded. SPEA was analyzed by using spectrophotometry. Results: SPEA of Group 2 was found to be statistically significantly higher than that of Groups 1 and 3 (p=0.004 and p=0.006,respectively). SPEA was positively correlated with the presence of attack (rs =0.265, p=0.003), erythrocyte sedimentationrate (rs =0.269, p=0.003), and C-reactive protein (rs =0.199, p=0.027). The relationship between FMF attack and SPEA wasevaluated by receiver operating characteristics analysis. Sensitivity and specificity were 91% and 67%, respectively, withan SPEA cut-off point of 817 U/L (AUC=0.769 [95% CI 0.626-0.912, p=0.003]). Conclusion: The FMF attack and the associated acute phase response may have an effect on increased SPEA. In FMF pa tients, an increased SPEA may play a role in both pathogenesis and progression of complications caused by the inflamma tory process.
AU  - Dogan, İsmail
AU  - dogan, ibrahim
AU  - kayadibi, huseyin
AU  - Eser, Baris
DO  - 10.5152/turkjnephrol.2021.4421
PY  - 2021
JO  - Turkish journal of nephrology (Online)
VL  - 30
IS  - 1
SN  - 2667-4440
SP  - 37
EP  - 42
DB  - TRDizin
UR  - http://search/yayin/detay/467190
ER  -