Comparison of topical acyclovir and penciclovir in recurrent herpes labialis treatment
Yıl: 2021 Cilt: 46 Sayı: 3 Sayfa Aralığı: 927 - 933 Metin Dili: İngilizce DOI: 10.17826/cumj.899262 İndeks Tarihi: 29-07-2022
Comparison of topical acyclovir and penciclovir in recurrent herpes labialis treatment
Öz: Purpose: The aim of this study is to compare the effects of acyclovir and penciclovir creams in the treatment of recurrent herpes labialis. Materials and Methods: Seventy patients with prediagnosed recurrent herpes labialis lesions were enrolled in this study. Diagnosis was confirmed with HSV-1 IgM antibody test. Patients were separated under 2 treatment groups as acyclovir and penciclovir cream. Both agents were applied until complete healing of the lesions was seen. Burning, itching and bleeding scores; time of erythema, vesicles, ulceration, crusting and crust loss of the lesions were recorded. Pain values of the patients were recorded using a visual analog scale (VAS) and DASS-21 scale was used to measure emotional state related to depression, anxiety and stress. Results: Pain level in the acyclovir group was significantly lower than the penciclovir group in the 3rd day, though with no difference in the following days. DASS-21 scores revealed signs of depression on 62.8% of the patients, anxiety on 34.2% of the patients, and stress on 41.4% of the patients in moderate or higher levels. While the pain level was higher in patients with high anxiety severity, it was observed that the pain level was low in patients with high stress intensity. Conclusion: Although it is not possible to cure recurrent herpes labialis completely, any methods and drugs that shorten the healing time of the lesion and reduce pain and discomfort gains importance. Our study showed that acyclovir is superior in reducing pain.
Anahtar Kelime: Rekürrent herpes labialisin tedavisinde topikal asiklovir ve pensiklovir etkinliklerinin karşılaştırılması
Öz: Giriş: Bu çalışmanın amacı, rekürrent herpes labialisin topikal tedavisinde asiklovir ve pensiklovir etken madde içeren kremlerin etkilerini karşılaştırmaktır. Gereç ve Yöntem: Çalışmamıza rekürrent herpes labialis tanı konmuş lezyonu olan 70 hasta dahil edildi. Teşhis HSV-1 IgM antikor testi ile doğrulandı. Hastalar asiklovir ve pensiklovir etken maddesi içeren kremlerin kullanıldığı iki tedavi grubuna ayrıldı. Her iki ajan lezyonlarda tam iyileşme görülene kadar uygulandı. Yanma, kaşıntı ve kanama skorları; lezyonların kızarıklık, vezikül, ülserasyon, kabuklanma ve kabuk kaybı zamanları kaydedildi. Hastaların ağrı değerleri görsel analog skala (VAS) ile kaydedildi ve depresyon, anksiyete ve stres ile ilgili duygusal durumu ölçmek için DASS-21 skalası kullanıldı. Bulgular: Asiklovir grubundaki ağrı düzeyi, sadece üçüncü günde pensiklovir grubuna göre anlamlı derecede düşüktü. DASS-21 skorları, hastaların %62,8'inde depresyon, %34,2'sinde anksiyete ve %41,4'ünde orta ve yüksek düzeyde stres belirtisi gösterdi. Anksiyete şiddeti yüksek hastalarda ağrı düzeyleri yüksek iken, stres yoğunluğu yüksek hastalarda ağrı düzeyinin düşük olduğu görüldü. Sonuç: Rekürrent herpes labialisin tamamen tedavisi mümkün olmamakla birlikte lezyonun iyileşme süresini kısaltan, ağrı ve rahatsızlığı azaltan her türlü yöntem ve ilaç önem kazanmaktadır. Bu bağlamda çalışmamız, asiklovir etken madde içeren ajanın, ağrıyı azaltmada pensiklovir etken maddesi içeren ajana göre daha üstün olduğunu göstermiştir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | GÜRBÜZ M, Kırtak N, TAŞ B (2021). Comparison of topical acyclovir and penciclovir in recurrent herpes labialis treatment. , 927 - 933. 10.17826/cumj.899262 |
| Chicago | GÜRBÜZ Mustafa Can,Kırtak Necmettin,TAŞ BETÜL Comparison of topical acyclovir and penciclovir in recurrent herpes labialis treatment. (2021): 927 - 933. 10.17826/cumj.899262 |
| MLA | GÜRBÜZ Mustafa Can,Kırtak Necmettin,TAŞ BETÜL Comparison of topical acyclovir and penciclovir in recurrent herpes labialis treatment. , 2021, ss.927 - 933. 10.17826/cumj.899262 |
| AMA | GÜRBÜZ M,Kırtak N,TAŞ B Comparison of topical acyclovir and penciclovir in recurrent herpes labialis treatment. . 2021; 927 - 933. 10.17826/cumj.899262 |
| Vancouver | GÜRBÜZ M,Kırtak N,TAŞ B Comparison of topical acyclovir and penciclovir in recurrent herpes labialis treatment. . 2021; 927 - 933. 10.17826/cumj.899262 |
| IEEE | GÜRBÜZ M,Kırtak N,TAŞ B "Comparison of topical acyclovir and penciclovir in recurrent herpes labialis treatment." , ss.927 - 933, 2021. 10.17826/cumj.899262 |
| ISNAD | GÜRBÜZ, Mustafa Can vd. "Comparison of topical acyclovir and penciclovir in recurrent herpes labialis treatment". (2021), 927-933. https://doi.org/10.17826/cumj.899262 |
| APA | GÜRBÜZ M, Kırtak N, TAŞ B (2021). Comparison of topical acyclovir and penciclovir in recurrent herpes labialis treatment. Cukurova Medical Journal, 46(3), 927 - 933. 10.17826/cumj.899262 |
| Chicago | GÜRBÜZ Mustafa Can,Kırtak Necmettin,TAŞ BETÜL Comparison of topical acyclovir and penciclovir in recurrent herpes labialis treatment. Cukurova Medical Journal 46, no.3 (2021): 927 - 933. 10.17826/cumj.899262 |
| MLA | GÜRBÜZ Mustafa Can,Kırtak Necmettin,TAŞ BETÜL Comparison of topical acyclovir and penciclovir in recurrent herpes labialis treatment. Cukurova Medical Journal, vol.46, no.3, 2021, ss.927 - 933. 10.17826/cumj.899262 |
| AMA | GÜRBÜZ M,Kırtak N,TAŞ B Comparison of topical acyclovir and penciclovir in recurrent herpes labialis treatment. Cukurova Medical Journal. 2021; 46(3): 927 - 933. 10.17826/cumj.899262 |
| Vancouver | GÜRBÜZ M,Kırtak N,TAŞ B Comparison of topical acyclovir and penciclovir in recurrent herpes labialis treatment. Cukurova Medical Journal. 2021; 46(3): 927 - 933. 10.17826/cumj.899262 |
| IEEE | GÜRBÜZ M,Kırtak N,TAŞ B "Comparison of topical acyclovir and penciclovir in recurrent herpes labialis treatment." Cukurova Medical Journal, 46, ss.927 - 933, 2021. 10.17826/cumj.899262 |
| ISNAD | GÜRBÜZ, Mustafa Can vd. "Comparison of topical acyclovir and penciclovir in recurrent herpes labialis treatment". Cukurova Medical Journal 46/3 (2021), 927-933. https://doi.org/10.17826/cumj.899262 |
