Low-Grade Tubulopapillary Adenocarcinoma ofSinonasal Tumors: Diagnosis and Follow-up
Yıl: 2021 Cilt: 27 Sayı: 4 Sayfa Aralığı: 704 - 709 Metin Dili: İngilizce DOI: 10.5336/dentalsci.2020-79413 İndeks Tarihi: 11-12-2021
Low-Grade Tubulopapillary Adenocarcinoma ofSinonasal Tumors: Diagnosis and Follow-up
Öz: Low grade tubulopapillary adenocarcinoma is one ofthe rare sinonasal tumors. A 65-year-old male patient was admittedto our clinic with painless intraoral and extraoral swelling and speechdisorder. Radiological examination of the patient revealed a lesionsuggesting malignancy. The area of the lesion spread from the leftmaxillary area to the maxillary sinus, nasal cavity, zygomatic boneand the base of the eye, causing resorption of the bones in the regions.As a result of biopsy, the lesion was diagnosed as well-differentiatedlow-grade tubulopapillary adenocarcinoma. The patient was referredto the oncology department of the medical faculty and the radiother apy was started by the medical faculty board, indicating that it was notsuitable for surgical treatment. After 1.5-year follow-up, the patientwas re-biopsied and diagnosed as poorly differentiated tubulopapil lary adenocarcinoma. We think that the aggressive lesion may showheterogeneous differentiation as a possible reason for the differentia tion between the two biopsies.
Anahtar Kelime: Sinonazal Tümörlerden Düşük Dereceli Tübülopapiller Adenokarsinomu: Tanı ve Takip
Öz: Düşük dereceli tübülopapiller adenokarsinom, çok nadir görü len sinonazal tümörlerden birisidir. Altmış beş yaşında erkek hasta, kli niğimize ağrısız intraoral ve ekstraoral şişlikle beraber konuşmabozukluğu şikâyetiyle başvurmuştur. Yapılan radyolojik muayenede,malignite düşündüren lezyon görülmüştür. İlgili lezyon alanı sol mak siller alandan başlayarak, sol maksiller sinüs, nazal kavite, zigoma vegöz tabanına kadar yayılmış olup, bölgedeki kemiklerde ileri seviyederezorpsiyona sebebiyet vermiştir. Yapılan immünokimyasal tetkiklersonucunda lezyona, iyi diferansiye düşük dereceli tübülopapiller ade nokarsinom tanısı konmuştur. Hasta; tıp fakültesi onkoloji servisineyönlendirilmiş ve yapılan konsültasyonlar sonucu cerrahi tedavi içinuygun olmadığı bildirilerek, radyoterapiye başlanmıştır. Hastanın 1,5yıllık takibinden sonra tekrar biyopsi alınmıştır ve biyopsi sonucundakötü diferansiye gösteren tübülopapiller adenokarsinom teşhisi konul muştur. İki biyopsi arasında diferansiyasyon farkının olmasının muh temel sebebi, ilk teşhis anında “düşük dereceli” olan yüksek yıkılımgösteren lezyonun, farklı diferansiye alanları bulundurmasından kay naklandığı düşünülmektedir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
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| APA | Miloğlu Ö, Naralan M, Açıkgöz G, sipal s (2021). Low-Grade Tubulopapillary Adenocarcinoma ofSinonasal Tumors: Diagnosis and Follow-up. , 704 - 709. 10.5336/dentalsci.2020-79413 |
| Chicago | Miloğlu Özkan,Naralan Muhammed Enes,Açıkgöz Gözde,sipal sare Low-Grade Tubulopapillary Adenocarcinoma ofSinonasal Tumors: Diagnosis and Follow-up. (2021): 704 - 709. 10.5336/dentalsci.2020-79413 |
| MLA | Miloğlu Özkan,Naralan Muhammed Enes,Açıkgöz Gözde,sipal sare Low-Grade Tubulopapillary Adenocarcinoma ofSinonasal Tumors: Diagnosis and Follow-up. , 2021, ss.704 - 709. 10.5336/dentalsci.2020-79413 |
| AMA | Miloğlu Ö,Naralan M,Açıkgöz G,sipal s Low-Grade Tubulopapillary Adenocarcinoma ofSinonasal Tumors: Diagnosis and Follow-up. . 2021; 704 - 709. 10.5336/dentalsci.2020-79413 |
| Vancouver | Miloğlu Ö,Naralan M,Açıkgöz G,sipal s Low-Grade Tubulopapillary Adenocarcinoma ofSinonasal Tumors: Diagnosis and Follow-up. . 2021; 704 - 709. 10.5336/dentalsci.2020-79413 |
| IEEE | Miloğlu Ö,Naralan M,Açıkgöz G,sipal s "Low-Grade Tubulopapillary Adenocarcinoma ofSinonasal Tumors: Diagnosis and Follow-up." , ss.704 - 709, 2021. 10.5336/dentalsci.2020-79413 |
| ISNAD | Miloğlu, Özkan vd. "Low-Grade Tubulopapillary Adenocarcinoma ofSinonasal Tumors: Diagnosis and Follow-up". (2021), 704-709. https://doi.org/10.5336/dentalsci.2020-79413 |
| APA | Miloğlu Ö, Naralan M, Açıkgöz G, sipal s (2021). Low-Grade Tubulopapillary Adenocarcinoma ofSinonasal Tumors: Diagnosis and Follow-up. Türkiye Klinikleri Diş Hekimliği Bilimleri Dergisi, 27(4), 704 - 709. 10.5336/dentalsci.2020-79413 |
| Chicago | Miloğlu Özkan,Naralan Muhammed Enes,Açıkgöz Gözde,sipal sare Low-Grade Tubulopapillary Adenocarcinoma ofSinonasal Tumors: Diagnosis and Follow-up. Türkiye Klinikleri Diş Hekimliği Bilimleri Dergisi 27, no.4 (2021): 704 - 709. 10.5336/dentalsci.2020-79413 |
| MLA | Miloğlu Özkan,Naralan Muhammed Enes,Açıkgöz Gözde,sipal sare Low-Grade Tubulopapillary Adenocarcinoma ofSinonasal Tumors: Diagnosis and Follow-up. Türkiye Klinikleri Diş Hekimliği Bilimleri Dergisi, vol.27, no.4, 2021, ss.704 - 709. 10.5336/dentalsci.2020-79413 |
| AMA | Miloğlu Ö,Naralan M,Açıkgöz G,sipal s Low-Grade Tubulopapillary Adenocarcinoma ofSinonasal Tumors: Diagnosis and Follow-up. Türkiye Klinikleri Diş Hekimliği Bilimleri Dergisi. 2021; 27(4): 704 - 709. 10.5336/dentalsci.2020-79413 |
| Vancouver | Miloğlu Ö,Naralan M,Açıkgöz G,sipal s Low-Grade Tubulopapillary Adenocarcinoma ofSinonasal Tumors: Diagnosis and Follow-up. Türkiye Klinikleri Diş Hekimliği Bilimleri Dergisi. 2021; 27(4): 704 - 709. 10.5336/dentalsci.2020-79413 |
| IEEE | Miloğlu Ö,Naralan M,Açıkgöz G,sipal s "Low-Grade Tubulopapillary Adenocarcinoma ofSinonasal Tumors: Diagnosis and Follow-up." Türkiye Klinikleri Diş Hekimliği Bilimleri Dergisi, 27, ss.704 - 709, 2021. 10.5336/dentalsci.2020-79413 |
| ISNAD | Miloğlu, Özkan vd. "Low-Grade Tubulopapillary Adenocarcinoma ofSinonasal Tumors: Diagnosis and Follow-up". Türkiye Klinikleri Diş Hekimliği Bilimleri Dergisi 27/4 (2021), 704-709. https://doi.org/10.5336/dentalsci.2020-79413 |
