Adrenomedullin, which is produced by the vascular endothelial and smooth muscle cells and cardiomyocytes, isconsidered to be a local factor controlling vascular tone, cardiac contractility, and renal sodium excretion. Hypertension isthe most common cause of cardiovascular disorders and diseases. Exercise has beneficial effects on hypertension, butpathophysiological factors involved in exercise‐mediated amelioration of hypertension are yet to be elucidated. Wehypothesized that adrenomedullin produced through exercise could play an essential role in the protection fromhypertension. For this study rats were subjected to swimming training for six weeks (1‐h per day and five times each week).Meanwhile, hypertension was induced by the oral administration of L‐NAME (60 mg/kg). Here, we show that L‐NAMEadministration per se leads to a significant increase in mean arterial blood pressure. Notably, the 6‐week swimming exercisecauses a protective effect from the development of hypertension. In addition, the rats rescued from hypertension have highmRNA levels of renal adrenomedullin while they have low levels of adrenomedullin mRNA in the aorta. The obtained dataindicate that a 6‐week exercise intervention rescues rats from high blood pressure by leading to changes in adrenomedullinlevels in the aorta and kidney. The increased expression of adrenomedullin in the aorta might have been a result thatcompensates for the hypertensive effect of L‐NAME. On the other hand, exercise probably exerts its protective effects onhypertension by increasing adrenomedullin in the kidney. A more extended exercise period may give more apparent resultsregarding the level of adrenomedullin in different organs.