Objectives: In this study, we aimed to investigate the contribution ofsystemic inflammatory biomarkers to the diagnosis and to examinethe relationship between cardiac parameters and malignancy inpatients with extremity soft tissue sarcomas (STSs). Patients and methods: Between January 2011 and December 2020,a total of 256 patients (155 males, 101 females; median age: 50 years;range, 18 to 87 years) who were diagnosed with benign and malignantsoft tissue tumors were retrospectively analyzed. The control groupconsisted of a total of 150 age- and sex-matched healthy individuals(83 males, 67 females; median age: 52 years; range 19 to 76 years)with complete blood count analysis and having no STS. Demographiccharacteristics, laboratory parameters, and echocardiographic dataof the patients were obtained from the hospital database. Theneutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyteratio (PLR) were calculated. Results: Of a total of 256 patients included, 99 were diagnosed withbenign tumors and 157 with malignant tumors. Lipoma was observedwith the highest frequency of 40.4% among benign tumors, whilemalignant mesenchymal tumor (35.0%) was the most common tumorin the malignant group. There was no significant difference betweenthe control and benign groups (p=0.198 and p=0.553, respectively),while the NLR and PLR of the malignant group were higher than boththe control and benign groups, indicating a statistical significance(p<0.001). Total cholesterol, albumin, and ejection fraction (EF)levels of patients in the malignant group were significantly lowerthan the benign group (p=0.01, p<0.001, and p=0.046, respectively).According to the receiver operating characteristic curve, a cut-offvalue of 2.17 for NLR (sensitivity=64.1%, specificity=72%) and acut-off value of 138.2 for PLR (sensitivity=60.9%, specificity=60.7%)were determined to distinguish malignant patients from healthyindividuals. To distinguish malignant patients from the benign group,the cut-off values of NLR and PLR were 2.24 (sensitivity=62.8%,specificity=67.7%) and 137.9 (sensitivity=61%, specificity= 59.6%),respectively. Conclusion: Our study results suggest that NLR and PLR can beused as diagnostic markers in malignant soft tissue tumors located inthe extremities. In addition, total cholesterol, albumin, and EF valuesare lower than normal in malignant soft tissue tumors.