Destek Ürünler ve COVID-19

AYAZ, CAGLAYAN MERVE; Dogu, Burcu Balam; Halil, Meltem; Ceylan, Serdar; Karaduman, Didem; Cankurtaran, Mustafa

doi:10.5578/flora.20219702

Destek Ürünler ve COVID-19

Serdar CEYLAN, (Hacettepe Üniversitesi, Tıp Fakültesi, Geriatri Bilim Dalı, Ankara, Türkiye)

Didem KARADUMAN, (Hacettepe Üniversitesi, Tıp Fakültesi, Geriatri Bilim Dalı, Ankara, Türkiye)

Cağlayan AYAZ, (Ankara Şehir Hastanesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, Ankara, Türkiye)

Burcu BALAM YAVUZ, (Hacettepe Üniversitesi, Tıp Fakültesi, Geriatri Bilim Dalı, Ankara, Türkiye)

Meltem HALİL, (Hacettepe Üniversitesi, Tıp Fakültesi, Geriatri Bilim Dalı, Ankara, Türkiye)

Mustafa CANKURTARAN (Hacettepe Üniversitesi, Tıp Fakültesi, Geriatri Bilim Dalı, Ankara, Türkiye)

Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi

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Yıl: 2021 Cilt: 26 Sayı: 3 Sayfa Aralığı: 353 - 360 Metin Dili: Türkçe DOI: 10.5578/flora.20219702 İndeks Tarihi: 31-12-2021

Destek Ürünler ve COVID-19

Öz:

Çin’de ortaya çıkıp dünyaya yayılan SARS-CoV-2 virüsü, COVID-19 adıyla anılan hastalığa neden olmuş; sonucunda Dünya Sağlık Örgütü tarafından 11 Mart 2020’de pandemi olarak ilan edilmiştir. İnsanlar için yeni bir virüs olan SARS-CoV-2, morbidite ve ölüm sayısında artışa neden olmuştur. Aşı ve ilaç alanındaki gelişmelere rağmen COVID-19’un olumsuz etkileri devam etmektedir. Morbidite ve mortalite yükü büyük tehdit oluşturan bir hastalık olan COVID-19 ortaya çıktıktan sonra virüsten korunmak ve yakalandıktan sonra hastalığı hafif atlatmak için çözümler aranmaya başlanmıştır. Güçlü bir immün sistemin infeksiyonlara karşı savaşta önemi bilindiğinden maske, mesafe ve hijyen önlemlerine ek olarak immüniteyi güçlendirecek yollar aranmaya başlanmıştır. Bu nedenle immün sistem üzerinde etkili olduğu düşünülen destek ürünlerinin popülaritesi artmıştır. Literatürde immünite ve diğer viral infeksiyonlarla ilgili olumlu çalışmalardan yola çıkılarak destek ürünlerin COVID-19’a karşı yararlı olabilecekleri düşünülmüştür. COVID-19 hakkındaki randomize kontrollü çalışmaları az olan destek ürünlerle ilgili çoğunlukla gözlemsel çalışmalar yayınlanmıştır. Derlememizde destek ürünlerin immünite, diğer viral infeksiyonlar ve COVID-19 üzerine etkileri incelenmiştir.

Anahtar Kelime:

Dietary Supplements and COVID-19

Öz:

SARS-CoV-2 virus, which emerged in China and spread worldwide, caused the disease called COVID-19, and as a result, it was declared as a pandemic by the World Health Organization on March 11, 2020. SARS-CoV-2, a new virus for humans, has caused an increase in morbidity and mortality rates. Despite developments in vaccines and drugs, unfavorable effects of COVID-19 keep going. After the emergence of COVID-19, a disease that poses a great threat of morbidity and mortality, solutions have been searched to avoid from the virus and to overcome the disease after getting sick. As the importance of a strong immune system in the fight against infections is known, ways to strengthen immunity have been sought in addition to masks, distance and hygiene measures. For this reason, popularity of dietary supplements, which are thought to be effective on the immune system, has increased. Based on the positive studies on immunity and other viral infections in the literature, it is thought that dietary supplements can be useful against COVID-19. About dietary supplements on COVID-19, there are only a few randomized controlled studies, observational studies have been published mostly. In this review, the effects of dietary supplements on immunity, other viral infections and COVID-19 were examined.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

1. World Health Organization (WHO). Coronavirus Disease (COVID-19) Dashboard. Available from: https://covid19. who.int/ (Accessed date: 12/04/2021).
2. Pan H, Peto R, Henao-Restrepo AM, Preziosi MP, Sathiyamoorthy V, Abdool Karim Q, et al. Repurposed antiviral drugs for Covid-19 - Interim WHO Solidarity trial results. N Engl J Med 2020;384:497-511.
3. Sterne JAC, Murthy S, Diaz JV, Slutsky AS, Villar J, Angus DC, et al. Association between administration of systemic corticosteroids and mortality among critically ill patients with COVID-19: A meta-analysis. JAMA 2020;324(13):1330-41.
4. Galmés S, Serra F, Palou A. Current state of evidence: influence of nutritional and nutrigenetic factors on immunity in the COVID-19 pandemic framework. Nutrients 2020;12(9):2738.
5. Greiller CL, Martineau AR. Modulation of the immune response to respiratory viruses by vitamin D. Nutrients 2015;7(6):4240-70.
6. Jolliffe DA, Camargo CA Jr., Sluyter JD, Aglipay M, Aloia JF, Ganmaa D, et al. Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials. Lancet Diabetes Endocrinol 2021;9(5):276-92.
7. Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, et al. Evidence that Vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths. Nutrients 2020;12(4):988.
8. Hastie CE, Pell JP, Sattar N. Vitamin D and COVID-19 infection and mortality in UK Biobank. Eur J Nutr 2021;60(1):545-8.
9. Liu N, Sun J, Wang X, Zhang T, Zhao M, Li H. Low vitamin D status is associated with coronavirus disease 2019 outcomes: a systematic review and meta-analysis. Int J Infect Dis 2021;104:58-64.
10. Teshome A, Adane A, Girma B, Mekonnen ZA. The Impact of Vitamin D Level on COVID-19 Infection: Systematic Review and Meta-Analysis. Front Public Health 2021;9:624559.
11. Radujkovic A, Hippchen T, Tiwari-Heckler S, Dreher S, Boxberger M, Merle U. Vitamin D deficiency and outcome of COVID-19 patients. Nutrient 2020;12(9).
12. Murai IH, Fernandes AL, Sales LP, Pinto AJ, Goessler KF, Duran CSC, et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A Randomized Clinical Trial. JAMA 2021;325(11):1053-60.
13. Wang R, DeGruttola V, Lei Q, Mayer KH, Redline S, Hazra A, et al. The vitamin D for COVID-19 (VIVID) trial: A pragmatic cluster-randomized design. Contemp Clin Trials 2021;100:106176.
14. Boulkrane MS, Ilina V, Melchakov R, Fedotova J, Drago F, Gozzo L, et al. COVID-19 disease and vitamin D: A mini-review. Front Pharmacol 2020;11:604579.
15. Carr AC, Maggini S. Vitamin C and Immune Function. Nutrients 2017;9(11):1211.
16. Gorton HC, Jarvis K. The effectiveness of vitamin C in preventing and relieving the symptoms of virus-induced respiratory infections. J Manipulative Physiol Ther 1999;22(8):530-3.
17. Douglas RM, Chalker EB, Treacy B. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev 2000(2):Cd000980.
18. Abobaker A, Alzwi A, Alraied AHA. Overview of the possible role of vitamin C in management of COVID-19. Pharmacolog Rep 2020;72(6):1517-28.
19. Hiedra R, Lo KB, Elbashabsheh M, Gul F, Wright RM, Albano J, et al. The use of IV vitamin C for patients with COVID-19: a case series. Expert Rev Anti Infect Ther 2020;18(12):1259-61.
20. Thomas S, Patel D, Bittel B, Wolski K, Wang Q, Kumar A, et al. Effect of high-dose zinc and ascorbic acid supplementation vs usual care on symptom length and reduction among ambulatory patients with SARS-CoV-2 infection: The COVID A to Z randomized clinical trial. JAMA Netw Open 2021;4(2):e210369.
21. Milani GP, Macchi M, Guz-Mark A. Vitamin C in the Treatment of COVID-19. Nutrients 2021;13(4):1172.
22. Singh R, Shaik L, Mehra I, Kashyap R, Surani S. Novel and controversial therapies in COVID-19. Open Respir Med J 2020;14:79-86.
23. Carr AC, Rowe S. The emerging role of vitamin C in the prevention and treatment of COVID-19. Nutrients 2020;12(11):3286.
24. Olechnowicz J, Tinkov A, Skalny A, Suliburska J. Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism. J Physiol Sci 2018;68(1):19-31.
25. Skalny AV, Rink L, Ajsuvakova OP, Aschner M, Gritsenko VA, Alekseenko SI, et al. Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review). Int J Mol Med 2020;46(1):17-26.
26. Wessels I, Rolles B, Slusarenko AJ, Rink L. Zinc deficiency as a possible risk factor for increased susceptibility and severe progression of Corona Virus Disease 19. Br J Nutr 2021:1- 19.
27. Meydani SN, Barnett JB, Dallal GE, Fine BC, Jacques PF, Leka LS, et al. Serum zinc and pneumonia in nursing home elderly. Am J Clin Nutr 2007;86(4):1167-73.
28. Barnett JB, Dao MC, Hamer DH, Kandel R, Brandeis G, Wu D, et al. Effect of zinc supplementation on serum zinc concentration and T cell proliferation in nursing home elderly: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 2016;103(3):942-51.
29. de Almeida Brasiel PG. The key role of zinc in elderly immunity: A possible approach in the COVID-19 crisis. Clin Nutr ESPEN 2020;38:65-6.
30. Jothimani D, Kailasam E, Danielraj S, Nallathambi B, Ramachandran H, Sekar P, et al. COVID-19: Poor outcomes in patients with zinc deficiency. Int J Infect Dis 2020;100:343- 9.
31. Perera M, El Khoury J, Chinni V, Bolton D, Qu L, Johnson P, et al. Randomised controlled trial for high-dose intravenous zinc as adjunctive therapy in SARS-CoV-2 (COVID-19) positive critically ill patients: trial protocol. BMJ Open 2020;10(12):e040580.
32. Domingo JL, Marquès M. The effects of some essential and toxic metals/metalloids in COVID-19: A review. Food Chem Toxicol 2021;152:112161.
33. Joachimiak MP. Zinc against COVID-19? Symptom surveillance and deficiency risk groups. PLoS Negl Trop Dis 2021;15(1):e0008895.
34. Tam M, Gómez S, González-Gross M, Marcos A. Possible roles of magnesium on the immune system. Eur J Clin Nutr 2003;57(10):1193-7.
35. Calder PC, Carr AC, Gombart AF, Eggersdorfer M. Optimal nutritional status for a well-functioning immune system is an important factor to protect against viral infections. Nutrients 2020;12(4):2696.
36. Alamdari NM, Afaghi S, Rahimi FS, Tarki FE, Tavana S, Zali A, et al. Mortality risk factors among hospitalized COVID-19 patients in a major referral center in Iran. Tohoku J Exp Med 2020;252(1):73-84.
37. Tang CF, Ding H, Jiao RQ, Wu XX, Kong LD. Possibility of magnesium supplementation for supportive treatment in patients with COVID-19. Eur J Pharmacol 2020;886:173546.
38. Wallace TC. Combating COVID-19 and building immune resilience: a potential role for magnesium nutrition? J Am Col Nutr 2020;39(8):685-93.
39. Guillin OM, Vindry C, Ohlmann T, Chavatte L. Selenium, selenoproteins and viral infection. Nutrients 2019;11(9):2101.
40. Harthill M. Review: micronutrient selenium deficiency influences evolution of some viral infectious diseases. Biol Trace Elem Res 2011;143(3):1325-36.
41. Steinbrenner H, Al-Quraishy S, Dkhil MA, Wunderlich F, Sies H. Dietary selenium in adjuvant therapy of viral and bacterial infections. Adv Nutr 2015;6(1):73-82.
42. Im JH, Je YS, Baek J, Chung MH, Kwon HY, Lee JS. Nutritional status of patients with COVID-19. Int J Infect Dis 2020;100:390-3.
43. Heller RA, Sun Q, Hackler J, Seelig J, Seibert L, Cherkezov A, et al. Prediction of survival odds in COVID-19 by zinc, age and selenoprotein P as composite biomarker. Redox Biol 2021;38:101764.
44. Kohn A, Gitelman J, Inbar M. Unsaturated free fatty acids inactivate animal enveloped viruses. Arch Virol 1980;66(4):301-7.
45. Kristine Koekkoek W, Panteleon V, van Zanten AR. Current evidence on ω-3 fatty acids in enteral nutrition in the critically ill: A systematic review and meta-analysis. Nutrition 2019;59:56-68.
46. Rogero MM, Leão MC, Santana TM, Pimentel M, Carlini GCG, da Silveira TFF, et al. Potential benefits and risks of omega-3 fatty acids supplementation to patients with COVID-19. Free Radic Biol Med 2020;156:190-9.
47. Farough S, Karaa A, Walker MA, Slate N, Dasu T, Verbsky J, et al. Coenzyme Q10 and immunity: A case report and new implications for treatment of recurrent infections in metabolic diseases. Clin Immunol 2014;155(2):209-12.
48. Fan L, Feng Y, Chen GC, Qin LQ, Fu CL, Chen LH. Effects of coenzyme Q10 supplementation on inflammatory markers: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res 2017;119:128-36.
49. Chase M, Cocchi MN, Liu X, Andersen LW, Holmberg MJ, Donnino MW. Coenzyme Q10 in acute influenza. Influenza Other Respir Viruses 2019;13(1):64-70.
50. Vassiliou AG, Mastora Z, Jahaj E, Keskinidou C, Pratikaki ME, Kampisiouli E, et al. Serum Coenzyme Q10 Levels are Decreased in Critically-Ill Septic Patients: Results From a Preliminary Study. Biol Res Nurs 2020;23(2):198-207.
51. Shenoy S. Coronavirus (Covid-19) sepsis: revisiting mitochondrial dysfunction in pathogenesis, aging, inflammation, and mortality. Inflamm Res 2020;69(11):1077-85.
52. Ouyang L, Gong J. Mitochondrial-targeted ubiquinone: A potential treatment for COVID-19. Med Hypothese 2020;144:110161.
53. Caruso F, Rossi M, Pedersen JZ, Incerpi S. Computational studies reveal mechanism by which quinone derivatives can inhibit SARS-CoV-2. Study of embelin and two therapeutic compounds of interest, methyl prednisolone and dexamethasone. J Infect Public Health 2020;13(12):1868-77.
54. Forman HJ, Zhang H, Rinna A. Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med 2009;30(1-2):1-12.
55. Silvagno F, Vernone A, Pescarmona GP. The Role of Glutathione in Protecting against the Severe Inflammatory Response Triggered by COVID-19. Antioxidants (Basel) 2020;9(7):624.
56. Guloyan V, Oganesian B, Baghdasaryan N, Yeh C, Singh M, Guilford F, et al. Glutathione Supplementation as an Adjunctive Therapy in COVID-19. Antioxidants (Basel) 2020;9(10):914.
57. Horowitz RI, Freeman PR, Bruzzese J. Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases. Resp Med Case Rep 2020;30:101063.
58. Sandvik A, Wang YY, Morton HC, Aasen AO, Wang JE, Johansen FE. Oral and systemic administration of beta-glucan protects against lipopolysaccharide-induced shock and organ injury in rats. Clin Exp Immunol 2007;148(1):168-77.
59. Feldman S, Schwartz HI, Kalman DS, Mayers A, Kohrman HM, Clemens R, et al. Randomized phase II clinical trials of wellmune WGP [R] for immune support during cold and flu season. J Appl Res 2009;9(1-2):30-43.
60. Murphy EJ, Masterson C, Rezoagli E, O’Toole D, Major I, Stack GD, et al. β-Glucan extracts from the same edible shiitake mushroom Lentinus edodes produce differential in-vitro immunomodulatory and pulmonary cytoprotective effects - Implications for coronavirus disease (COVID-19) immunotherapies. Sci Total Environ 2020;732:139330.
61. Jawhara S. How to boost the immune defence prior to respiratory virus infections with the special focus on coronavirus infections. Gut Pathog 2020;12:47.
62. Salehi B, Mishra AP, Nigam M, Sener B, Kilic M, Sharifi-Rad M, et al. Resveratrol: A Double-Edged Sword in Health Benefits. Biomedicines 2018;6(3).
63. Malaguarnera L. Influence of Resveratrol on the Immune Response. Nutrients 2019;11(5).
64. Filardo S, Di Pietro M, Mastromarino P, Sessa R. Therapeutic potential of resveratrol against emerging respiratory viral infections. Pharmacol Ther 2020;214:107613.
65. Ranjbar A, Jamshidi M, Torabi S. Molecular modelling of the antiviral action of Resveratrol derivatives against the activity of two novel SARS CoV-2 and 2019-nCoV receptors. Eur Rev Med Pharmacol Sci 2020;24(14):7834-44.
66. Moghadamtousi SZ, Kadir HA, Hassandarvish P, Tajik H, Abubakar S, Zandi K. A review on antibacterial, antiviral, and antifungal activity of curcumin. BioMed Res Int 2014;2014:186864.
67. Babaei F, Nassiri-Asl M, Hosseinzadeh H. Curcumin (a constituent of turmeric): New treatment option against COVID-19. Food Sci Nutr 2020;8(10):5215-27.
68. Valizadeh H, Abdolmohammadi-Vahid S, Danshina S, Ziya Gencer M, Ammari A, Sadeghi A, et al. Nano-curcumin therapy, a promising method in modulating inflammatory cytokines in COVID-19 patients. Int Immunopharmacol 2020;89(Pt B):107088.
69. Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nature Rev Gastroenterol Hepatol 2014;11(8):506-14.
70. Hao Q, Dong BR, Wu T. Probiotics for preventing acute upper respiratory tract infections. Cochrane Database Syst Rev 2015(2):Cd006895.
71. Akour A. Probiotics and COVID-19: is there any link? Lett Appl Microbiol 2020;71(3):229-34.
72. Olaimat AN, Aolymat I, Al-Holy M, Ayyash M, Abu Ghoush M, Al-Nabulsi AA, et al. The potential application of probiotics and prebiotics for the prevention and treatment of COVID-19. NPJ Sci Food 2020;4:17.
73. Baud D, Dimopoulou Agri V, Gibson GR, Reid G, Giannoni E. Using probiotics to flatten the curve of coronavirus disease COVID-2019 Pandemic. Front Public Health 2020;8:186.
74. Tiwari SK, Dicks LMT, Popov IV, Karaseva A, Ermakov AM, Suvorov A, et al. Probiotics at War Against Viruses: What Is Missing From the Picture? Front Microbiol 2020;11:1877.

APA	Ceylan S, Karaduman D, AYAZ C, Dogu B, Halil M, Cankurtaran M (2021). Destek Ürünler ve COVID-19. , 353 - 360. 10.5578/flora.20219702
Chicago	Ceylan Serdar,Karaduman Didem,AYAZ CAGLAYAN MERVE,Dogu Burcu Balam,Halil Meltem,Cankurtaran Mustafa Destek Ürünler ve COVID-19. (2021): 353 - 360. 10.5578/flora.20219702
MLA	Ceylan Serdar,Karaduman Didem,AYAZ CAGLAYAN MERVE,Dogu Burcu Balam,Halil Meltem,Cankurtaran Mustafa Destek Ürünler ve COVID-19. , 2021, ss.353 - 360. 10.5578/flora.20219702
AMA	Ceylan S,Karaduman D,AYAZ C,Dogu B,Halil M,Cankurtaran M Destek Ürünler ve COVID-19. . 2021; 353 - 360. 10.5578/flora.20219702
Vancouver	Ceylan S,Karaduman D,AYAZ C,Dogu B,Halil M,Cankurtaran M Destek Ürünler ve COVID-19. . 2021; 353 - 360. 10.5578/flora.20219702
IEEE	Ceylan S,Karaduman D,AYAZ C,Dogu B,Halil M,Cankurtaran M "Destek Ürünler ve COVID-19." , ss.353 - 360, 2021. 10.5578/flora.20219702
ISNAD	Ceylan, Serdar vd. "Destek Ürünler ve COVID-19". (2021), 353-360. https://doi.org/10.5578/flora.20219702

APA	Ceylan S, Karaduman D, AYAZ C, Dogu B, Halil M, Cankurtaran M (2021). Destek Ürünler ve COVID-19. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, 26(3), 353 - 360. 10.5578/flora.20219702
Chicago	Ceylan Serdar,Karaduman Didem,AYAZ CAGLAYAN MERVE,Dogu Burcu Balam,Halil Meltem,Cankurtaran Mustafa Destek Ürünler ve COVID-19. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi 26, no.3 (2021): 353 - 360. 10.5578/flora.20219702
MLA	Ceylan Serdar,Karaduman Didem,AYAZ CAGLAYAN MERVE,Dogu Burcu Balam,Halil Meltem,Cankurtaran Mustafa Destek Ürünler ve COVID-19. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, vol.26, no.3, 2021, ss.353 - 360. 10.5578/flora.20219702
AMA	Ceylan S,Karaduman D,AYAZ C,Dogu B,Halil M,Cankurtaran M Destek Ürünler ve COVID-19. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi. 2021; 26(3): 353 - 360. 10.5578/flora.20219702
Vancouver	Ceylan S,Karaduman D,AYAZ C,Dogu B,Halil M,Cankurtaran M Destek Ürünler ve COVID-19. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi. 2021; 26(3): 353 - 360. 10.5578/flora.20219702
IEEE	Ceylan S,Karaduman D,AYAZ C,Dogu B,Halil M,Cankurtaran M "Destek Ürünler ve COVID-19." Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, 26, ss.353 - 360, 2021. 10.5578/flora.20219702
ISNAD	Ceylan, Serdar vd. "Destek Ürünler ve COVID-19". Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi 26/3 (2021), 353-360. https://doi.org/10.5578/flora.20219702