Recent success of pantoprazole -or lansoprazole- based clarithromycin plus amoxicillin treatment in the eradication of Helicobacter pylori

ATEŞ, Yüksel; KADAYIFÇI, Abdurrahman; DAĞALP, Kemal; BAĞCI, Sait; YEŞİLOVA, Zeki; CİĞERİM, Murat; Uygun, Ahmet; SAVAŞ, M. Cemil; KARSLIOĞLU, Yıldırım

Recent success of pantoprazole -or lansoprazole- based clarithromycin plus amoxicillin treatment in the eradication of Helicobacter pylori

Ahmet UYGUN, (GATA Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, Ankara, Türkiye)

Abdurrahman KADAYIFÇI, (Gaziantep Üniversitesi, Tıp Fakültesi, Gastroenteroloji Bilim Dalı, Gaziantep, Türkiye)

Zeki YEŞİLOVA, (GATA Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, Ankara, Türkiye)

M. Cemil SAVAŞ, (Gaziantep Üniversitesi, Tıp Fakültesi, Gastroenteroloji Bilim Dalı, Gaziantep, Türkiye)

Yüksel ATEŞ, (GATA Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, Ankara, Türkiye)

Yıldırım KARSLIOĞLU, (GATA Askeri Tıp Fakültesi, Patoloji Anabilim Dalı, Ankara, Türkiye)

Murat CİĞERİM, (GATA Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, Ankara, Türkiye)

Sait BAĞCI, (GATA Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, Ankara, Türkiye)

Kemal DAĞALP (GATA Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, Ankara, Türkiye)

Turkish Journal of Gastroenterology

6 0

Yıl: 2004 Cilt: 15 Sayı: 4 Sayfa Aralığı: 219 - 224 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Recent success of pantoprazole -or lansoprazole- based clarithromycin plus amoxicillin treatment in the eradication of Helicobacter pylori

Öz:

Amaç: Son yıllarda H. pylorinin klaritromisine karşı direncinin arttığına dair çok sayıda çalışma bildirilmektedir. Bu çalışmada H.pylori eradikasyonunda en çok kullanılan ilk basamak eradikasyon şemasının güncel başarısının iki farklı proton pompa inhibitörü; pantoprazol ve lansoprazol kullanılarak araştırılması amaçlandı.Yöntem: H. pylori pozitif fonksiyonel dispepsisi olan 90 hasta çok merkezli bir çalışmada pantoprazol 2x40mg veya lansoprazol 2x30mg ile birlikte amoksisilin 2x1000mg ve klaritromisin 2x500mg 14 gün süreyle alacak şekilde 2 ayrı gruba randomize edildi. H. pylori histoloji ve hızlı üreaz testi ile belirlendi. Eradikasyon tedavisinden 6 hafta sonra kontrol endokopi yapılarak H. pylori araştırıldı.Bulgular: Yetmişdokuz hasta protokolü tamamladı. Per protokol analizinde pantoprazol, amoksisilin, klaritromisin grubunda %70 (28/40), lansoprazol, amoksisilin, klaritromisin grubunda %69.2 (27/39) eradikasyon saptandı. Tedavi hedeflenen gruptaki eradikasyon oranları pantoprazol, amoksisilin, klaritromisin grubunda %62.2, lansoprazol, amoksisilin, klaritromisin grubunda %60 olarak belirlendi. İki grup arasında eradikasyon oranları açısından fark saptanmadı (p>0.05)Sonuç: H. pylori için halen en popüler olan ve PPI, klaritromisin, amoksisilinden oluşan ilk basamak eradikasyon rejimi bu çalışmada orta derecede bir başarı sağlamıştır. H. pylori eradikasyonunda alternatif tedavilere ihtiyaç vardır. Proton pompa inhibitör seçimi eradikasyonun başarısını etkilememektedir.

Anahtar Kelime: pantoprazol Omeprazol Dispepsi Klaritromisin Helicobacter pylori Lanzoprazol Amoksisilin

Konular: Cerrahi

Pantoprazol veya lansoprazol ile amoksisilin ve klaritromisin içeren rejimlerin Helikobakter pilori eradikasyonundaki güncel durumu

Öz:

Background/aims: There are some reports showing that resistance of Helicobacter pylori (H. pylori) to clarithromycin has increased in recent years. We aimed to investigate the current success of a most popular first-line eradication regimen by using two different proton pump inhibitors: lansoprazole and pantoprazole.Methods: Ninety patients with H. pylori-positive functional dyspepsia were randomized to receive pantoprazole 40 mg b.i.d. or lansoprazole 30 mg b.i.d. in addition to amoxicillin 1000 mg and clarithromycin 500 mg twice daily for 14 days in a multicenter study. H. pylori infection was determined by histological examination and a rapid urease test. A follow-up endoscopy was performed to assess the H. pylori eradication six weeks after the end of therapy.Results: Seventy-nine patients completed the study protocol properly. The H. pylori eradication rates according to per protocol analysis were 70% in group pantoprazole, amoxicillin and clarithromycin (28/40) and 69.2% in group pantoprazole, amoxicillin and clarithromycin (27/39). The eradication rates according to intention to treat analysis were 62.2% and 60% in lansoprazole, amoxicillin, clarithromycin, pantoprazole, amoxicillin, clarithromycin groups, respectively. The eradication rates were similar in both protocols (p>0.05). Conclusions: The most popular first-line eradication protocols of H. pylori achieved only a moderate success in the current study. Alternative therapy options are needed instead of clarithromycin-based triple treatment for eradication of H. pylori. The choice of proton pump inhibitor is not important in the eradication rate of H. pylori.

Anahtar Kelime: Dyspepsia Clarithromycin Helicobacter pylori Lansoprazole Amoxicillin pantoprazole Omeprazole

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Uygun A, KADAYIFÇI A, YEŞİLOVA Z, SAVAŞ M, ATEŞ Y, KARSLIOĞLU Y, CİĞERİM M, BAĞCI S, DAĞALP K (2004). Recent success of pantoprazole -or lansoprazole- based clarithromycin plus amoxicillin treatment in the eradication of Helicobacter pylori. , 219 - 224.
Chicago	Uygun Ahmet,KADAYIFÇI Abdurrahman,YEŞİLOVA Zeki,SAVAŞ M. Cemil,ATEŞ Yüksel,KARSLIOĞLU Yıldırım,CİĞERİM Murat,BAĞCI Sait,DAĞALP Kemal Recent success of pantoprazole -or lansoprazole- based clarithromycin plus amoxicillin treatment in the eradication of Helicobacter pylori. (2004): 219 - 224.
MLA	Uygun Ahmet,KADAYIFÇI Abdurrahman,YEŞİLOVA Zeki,SAVAŞ M. Cemil,ATEŞ Yüksel,KARSLIOĞLU Yıldırım,CİĞERİM Murat,BAĞCI Sait,DAĞALP Kemal Recent success of pantoprazole -or lansoprazole- based clarithromycin plus amoxicillin treatment in the eradication of Helicobacter pylori. , 2004, ss.219 - 224.
AMA	Uygun A,KADAYIFÇI A,YEŞİLOVA Z,SAVAŞ M,ATEŞ Y,KARSLIOĞLU Y,CİĞERİM M,BAĞCI S,DAĞALP K Recent success of pantoprazole -or lansoprazole- based clarithromycin plus amoxicillin treatment in the eradication of Helicobacter pylori. . 2004; 219 - 224.
Vancouver	Uygun A,KADAYIFÇI A,YEŞİLOVA Z,SAVAŞ M,ATEŞ Y,KARSLIOĞLU Y,CİĞERİM M,BAĞCI S,DAĞALP K Recent success of pantoprazole -or lansoprazole- based clarithromycin plus amoxicillin treatment in the eradication of Helicobacter pylori. . 2004; 219 - 224.
IEEE	Uygun A,KADAYIFÇI A,YEŞİLOVA Z,SAVAŞ M,ATEŞ Y,KARSLIOĞLU Y,CİĞERİM M,BAĞCI S,DAĞALP K "Recent success of pantoprazole -or lansoprazole- based clarithromycin plus amoxicillin treatment in the eradication of Helicobacter pylori." , ss.219 - 224, 2004.
ISNAD	Uygun, Ahmet vd. "Recent success of pantoprazole -or lansoprazole- based clarithromycin plus amoxicillin treatment in the eradication of Helicobacter pylori". (2004), 219-224.

APA	Uygun A, KADAYIFÇI A, YEŞİLOVA Z, SAVAŞ M, ATEŞ Y, KARSLIOĞLU Y, CİĞERİM M, BAĞCI S, DAĞALP K (2004). Recent success of pantoprazole -or lansoprazole- based clarithromycin plus amoxicillin treatment in the eradication of Helicobacter pylori. Turkish Journal of Gastroenterology, 15(4), 219 - 224.
Chicago	Uygun Ahmet,KADAYIFÇI Abdurrahman,YEŞİLOVA Zeki,SAVAŞ M. Cemil,ATEŞ Yüksel,KARSLIOĞLU Yıldırım,CİĞERİM Murat,BAĞCI Sait,DAĞALP Kemal Recent success of pantoprazole -or lansoprazole- based clarithromycin plus amoxicillin treatment in the eradication of Helicobacter pylori. Turkish Journal of Gastroenterology 15, no.4 (2004): 219 - 224.
MLA	Uygun Ahmet,KADAYIFÇI Abdurrahman,YEŞİLOVA Zeki,SAVAŞ M. Cemil,ATEŞ Yüksel,KARSLIOĞLU Yıldırım,CİĞERİM Murat,BAĞCI Sait,DAĞALP Kemal Recent success of pantoprazole -or lansoprazole- based clarithromycin plus amoxicillin treatment in the eradication of Helicobacter pylori. Turkish Journal of Gastroenterology, vol.15, no.4, 2004, ss.219 - 224.
AMA	Uygun A,KADAYIFÇI A,YEŞİLOVA Z,SAVAŞ M,ATEŞ Y,KARSLIOĞLU Y,CİĞERİM M,BAĞCI S,DAĞALP K Recent success of pantoprazole -or lansoprazole- based clarithromycin plus amoxicillin treatment in the eradication of Helicobacter pylori. Turkish Journal of Gastroenterology. 2004; 15(4): 219 - 224.
Vancouver	Uygun A,KADAYIFÇI A,YEŞİLOVA Z,SAVAŞ M,ATEŞ Y,KARSLIOĞLU Y,CİĞERİM M,BAĞCI S,DAĞALP K Recent success of pantoprazole -or lansoprazole- based clarithromycin plus amoxicillin treatment in the eradication of Helicobacter pylori. Turkish Journal of Gastroenterology. 2004; 15(4): 219 - 224.
IEEE	Uygun A,KADAYIFÇI A,YEŞİLOVA Z,SAVAŞ M,ATEŞ Y,KARSLIOĞLU Y,CİĞERİM M,BAĞCI S,DAĞALP K "Recent success of pantoprazole -or lansoprazole- based clarithromycin plus amoxicillin treatment in the eradication of Helicobacter pylori." Turkish Journal of Gastroenterology, 15, ss.219 - 224, 2004.
ISNAD	Uygun, Ahmet vd. "Recent success of pantoprazole -or lansoprazole- based clarithromycin plus amoxicillin treatment in the eradication of Helicobacter pylori". Turkish Journal of Gastroenterology 15/4 (2004), 219-224.