Antineutrophil cytoplasmic autoantibodies and anti-Saccharomyces cerevisiae antibodies in inflammatory bowel diseases

Filik, Levent; AYAZ, Selime; KILIÇ, Z. Mesut Yalın; AKTAŞ, Semra; ÜLKER, Aysel; TUNÇ, Bilge; PARLAK, Erkan

Antineutrophil cytoplasmic autoantibodies and anti-Saccharomyces cerevisiae antibodies in inflammatory bowel diseases

Z. Mesut Yalın KILIÇ, (Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Gastroenteroloji Kliniği, Ankara, Türkiye)

Bilge TUNÇ, (Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Gastroenteroloji Kliniği, Ankara, Türkiye)

Selime AYAZ, (Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Hematoloji Kliniği, Ankara, Türkiye)

Levent FİLİK, (Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Gastroenteroloji Kliniği, Ankara, Türkiye)

Semra AKTAŞ, (Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Gastroenteroloji Kliniği, Ankara, Türkiye)

Erkan PARLAK, (Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Gastroenteroloji Kliniği, Ankara, Türkiye)

Aysel ÜLKER (Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Gastroenteroloji Kliniği, Ankara, Türkiye)

Turkish Journal of Gastroenterology

1 0

Yıl: 2004 Cilt: 15 Sayı: 4 Sayfa Aralığı: 238 - 242 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Antineutrophil cytoplasmic autoantibodies and anti-Saccharomyces cerevisiae antibodies in inflammatory bowel diseases

Öz:

Amaç: Perinükleer antinötrofilik sitoplazmik antikor ülseratif kolit için bir gösterge, anti-Saccharomyces cerevisiae ise Crohn hastalığına eşlik eden bir antikordur. Bu çalışmanın amacı, perinükleer antinötrofilik sitoplazmik antikor ve anti-Saccharomyces cerevisiae antikounun Türk inflamatuvar barsak hastalarındaki önemini ve yerini ortaya koymaktır.Yöntem: 80 ülseratif kolit, 61 Crohn hastası ve 40 sağlıklı bireyden serum örnekleri alınmıştır. Perinükleer antinötrofil sitoplazmik antikor ve “anti-Saccharomyces cerevisiae” antikorları standardize edilmiş ELİZA yöntemi ile ölçülmüştür.Bulgular: Perinükleer antinötrofil sitoplazmik antikor, ülseratif kolitli olguların %65’inde, sağlıklı bireylerin %2.5’inde seropozitif bulunmuştur. Anti-Saccharomyces cerevisiae antikorları ise Crohn hastalarının %63.9’unda, sağlıklı bireylerin %2.5’inde seropozitif bulunmuştur. Perinükleer antinötrofil sitoplazmik antikor seronegatifliği ve “anti-Saccharomyces cerevisiae” antikorunun seropozitifliğinin birlikte tanı duyarlılığı ve özgüllüğü sırasıyla %32.0 ve %97.5’tir. Perinükleer antinötrofil sitoplazmik antikor seropozitifliği ve “anti-Saccharomyces cerevisiae” antikorunun seronegatifliğinin birlikte tanı duyarlılığı ve özgüllüğü sırasıyla %44.2 ve %97.5’tir.Sonuç: Her iki serolojik test, inflamatuvar barsak hastalığı tanısında yardımcı testler olabilir.

Anahtar Kelime: Antikorlar, antinötrofil sitoplazmik Saccharomyces cerevisiae Enflamatuvar bağırsak hastalıkları Antikorlar, fungal

Konular: Cerrahi

İnflamatuvar barsak hastalıklarında antinötrofil sitoplazmik antikor ve “anti-Saccharomyces cerevisiae” antikorları

Öz:

Background/aims: Perinuclear antineutrophil cytoplasmic autoantibody is a marker for ulcerative colitis, and anti-Saccharomyces cerevisiae antibody is known to be associated with Crohn's disease. The purpose of this study was to search the value of detecting perinuclear antineutrophil cytoplasmic autoantibody and anti-Saccharomyces cerevisiae antibody for the diagnosis of Turkish inflammatory bowel disease patients.Methods: Serum samples were obtained from 80 patients with ulcerative colitis, 61 patients with Crohn's disease and 40 healthy controls. Determination of both anti-Saccharomyces cerevisiae antibody and antineutrophil cytoplasmic autoantibody was performed with the standardized enzyme-linked immunosorbent assay.Results: In cases with ulcerative colitis, 65% tested seropositive for antineutrophil cytoplasmic autoantibody, whereas the controls showed 2.5% positivity. In cases with Crohn's disease, 63.9% tested seropositive for anti-Saccharomyces cerevisiae antibody, whereas the controls showed 2.5% seropositivity. The combination of a positive anti-Saccharomyces cerevisiae antibody test and a negative antineutrophil cytoplasmic autoantibody yielded a sensitivity and specificity of 32.0% and 97.5%, respectively. The combination of a positive perinuclear antineutrophil cytoplasmic autoantibody and a negative anti-Saccharomyces cerevisiae antibody test yielded a sensitivity and specificity of 44.2% and 97.5%, respectively.Conclusions: Both serologic tests may aid in the differential diagnosis of inflammatory bowel disease.

Anahtar Kelime: Saccharomyces cerevisiae Inflammatory Bowel Diseases Antibodies, Fungal Antibodies, Antineutrophil Cytoplasmic

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KILIÇ Z, TUNÇ B, AYAZ S, Filik L, AKTAŞ S, PARLAK E, ÜLKER A (2004). Antineutrophil cytoplasmic autoantibodies and anti-Saccharomyces cerevisiae antibodies in inflammatory bowel diseases. , 238 - 242.
Chicago	KILIÇ Z. Mesut Yalın,TUNÇ Bilge,AYAZ Selime,Filik Levent,AKTAŞ Semra,PARLAK Erkan,ÜLKER Aysel Antineutrophil cytoplasmic autoantibodies and anti-Saccharomyces cerevisiae antibodies in inflammatory bowel diseases. (2004): 238 - 242.
MLA	KILIÇ Z. Mesut Yalın,TUNÇ Bilge,AYAZ Selime,Filik Levent,AKTAŞ Semra,PARLAK Erkan,ÜLKER Aysel Antineutrophil cytoplasmic autoantibodies and anti-Saccharomyces cerevisiae antibodies in inflammatory bowel diseases. , 2004, ss.238 - 242.
AMA	KILIÇ Z,TUNÇ B,AYAZ S,Filik L,AKTAŞ S,PARLAK E,ÜLKER A Antineutrophil cytoplasmic autoantibodies and anti-Saccharomyces cerevisiae antibodies in inflammatory bowel diseases. . 2004; 238 - 242.
Vancouver	KILIÇ Z,TUNÇ B,AYAZ S,Filik L,AKTAŞ S,PARLAK E,ÜLKER A Antineutrophil cytoplasmic autoantibodies and anti-Saccharomyces cerevisiae antibodies in inflammatory bowel diseases. . 2004; 238 - 242.
IEEE	KILIÇ Z,TUNÇ B,AYAZ S,Filik L,AKTAŞ S,PARLAK E,ÜLKER A "Antineutrophil cytoplasmic autoantibodies and anti-Saccharomyces cerevisiae antibodies in inflammatory bowel diseases." , ss.238 - 242, 2004.
ISNAD	KILIÇ, Z. Mesut Yalın vd. "Antineutrophil cytoplasmic autoantibodies and anti-Saccharomyces cerevisiae antibodies in inflammatory bowel diseases". (2004), 238-242.

APA	KILIÇ Z, TUNÇ B, AYAZ S, Filik L, AKTAŞ S, PARLAK E, ÜLKER A (2004). Antineutrophil cytoplasmic autoantibodies and anti-Saccharomyces cerevisiae antibodies in inflammatory bowel diseases. Turkish Journal of Gastroenterology, 15(4), 238 - 242.
Chicago	KILIÇ Z. Mesut Yalın,TUNÇ Bilge,AYAZ Selime,Filik Levent,AKTAŞ Semra,PARLAK Erkan,ÜLKER Aysel Antineutrophil cytoplasmic autoantibodies and anti-Saccharomyces cerevisiae antibodies in inflammatory bowel diseases. Turkish Journal of Gastroenterology 15, no.4 (2004): 238 - 242.
MLA	KILIÇ Z. Mesut Yalın,TUNÇ Bilge,AYAZ Selime,Filik Levent,AKTAŞ Semra,PARLAK Erkan,ÜLKER Aysel Antineutrophil cytoplasmic autoantibodies and anti-Saccharomyces cerevisiae antibodies in inflammatory bowel diseases. Turkish Journal of Gastroenterology, vol.15, no.4, 2004, ss.238 - 242.
AMA	KILIÇ Z,TUNÇ B,AYAZ S,Filik L,AKTAŞ S,PARLAK E,ÜLKER A Antineutrophil cytoplasmic autoantibodies and anti-Saccharomyces cerevisiae antibodies in inflammatory bowel diseases. Turkish Journal of Gastroenterology. 2004; 15(4): 238 - 242.
Vancouver	KILIÇ Z,TUNÇ B,AYAZ S,Filik L,AKTAŞ S,PARLAK E,ÜLKER A Antineutrophil cytoplasmic autoantibodies and anti-Saccharomyces cerevisiae antibodies in inflammatory bowel diseases. Turkish Journal of Gastroenterology. 2004; 15(4): 238 - 242.
IEEE	KILIÇ Z,TUNÇ B,AYAZ S,Filik L,AKTAŞ S,PARLAK E,ÜLKER A "Antineutrophil cytoplasmic autoantibodies and anti-Saccharomyces cerevisiae antibodies in inflammatory bowel diseases." Turkish Journal of Gastroenterology, 15, ss.238 - 242, 2004.
ISNAD	KILIÇ, Z. Mesut Yalın vd. "Antineutrophil cytoplasmic autoantibodies and anti-Saccharomyces cerevisiae antibodies in inflammatory bowel diseases". Turkish Journal of Gastroenterology 15/4 (2004), 238-242.