Effect of hyperparathyroidism on coagulation: a global assessment by modified rotation thromboelastogram (ROTEM)

Bilgin, Muzaffer; AKALIN, AYSEN; EFE, FATMA BELGIN; GUNDUZ, Eren; Kalkan, Ahmet Toygar; Badak, Bartu; Aydin Buyruk, Betul; Kebapci, Medine  Nur; akay, olga meltem; Yorulmaz, Goknur; Alagüney, Elif Sevil

doi:10.3906/sag-2012-247

Effect of hyperparathyroidism on coagulation: a global assessment by modified rotation thromboelastogram (ROTEM)

Goknur YORULMAZ, (Osmangazi Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Anabilim Dalı, Eskişehir, Türkiye)

Ahmet Toygar KALKAN, (Osmangazi Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Anabilim Dalı, Eskişehir, Türkiye)

Aysen AKALIN, (Osmangazi Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Anabilim Dalı, Eskişehir, Türkiye)

Elif Sevil ALAGÜNEY, (Osmangazi Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Anabilim Dalı, Eskişehir, Türkiye)

Eren GUNDUZ, (Osmangazi Üniversitesi, Tıp Fakültesi, Hematoloji Anabilim Dalı, Eskişehir, Türkiye)

Bartu BADAK, (Osmangazi Üniversitesi, Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Eskişehir, Türkiye)

Betül AYDIN BUYRUK, (Osmangazi Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Anabilim Dalı, Eskişehir, Türkiye)

Medine Nur KEBAPÇI, (Osmangazi Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Anabilim Dalı, Eskişehir, Türkiye)

Fatma Belgin EFE, (Osmangazi Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Anabilim Dalı, Eskişehir, Türkiye)

Muzaffer BİLGİN, (Osmangazi Üniversitesi, Biyoistatistik ve Tıp Bilişimi Anabilim Dalı, Tıp Fakültesi, Eskişehir, Türkiye)

Olga YANAR, (Koç Üniversitesi, Tıp Fakültesi, Hematoloji Anabilim Dalı, İstanbul, Türkiye)

Diğer Yazarlar

Turkish Journal of Medical Sciences

3 0

Yıl: 2021 Cilt: 51 Sayı: 6 Sayfa Aralığı: 2897 - 2902 Metin Dili: İngilizce DOI: 10.3906/sag-2012-247 İndeks Tarihi: 04-01-2022

Effect of hyperparathyroidism on coagulation: a global assessment by modified rotation thromboelastogram (ROTEM)

Öz:

Background/aim: Hyperparathyroidism is an endocrine disorder characterized by hypercalcemia. Because of calcium’s effects on parathyroid glands, bone, intestines, and kidneys, it has an important place in homeostasis. The results of studies regarding hyperparathyroidism hemostasis are conflicting. Thromboelastography helps to evaluate all steps of hemostatic system. Our aim in this study was to investigate the possible role of hemostatic mechanisms in the development of thrombosis in hyperparathyroid patients with the modified rotation thromboelastogram (ROTEM). Materials and methods: Twenty-two patients with primary hyperparathyroidism (PHPT) and 20 healthy controls were involved. This study was conducted in Eskisehir Osmangazi University Faculty of Medicine, Endocrinology and Hematology clinics for 2 years. The complete blood count, fibrinogen, D-dimer levels, prothrombin time, activated prothrombin time, and ROTEM parameters [clot formation time (CFT), clotting time (CT), and maximum clot formation (MCF)] were determined by two activated tests, INTEM and EXTEM analyses. A thromboelastographic evaluation was performed in the preoperative and postoperative (3 months after surgery) periods. Results: In INTEM assay, the CT (p = 0.012) and CFT (p = 0.07) values were increased in preoperative PHPT patients compared with the control group. Although there was a decrease in the postoperative CT and CFT values, no statistical difference was found. Conclusion: The prolongation of the CT and CFT values were consistent with a hypocoagulable state in patients with PHPT. Hyperparathyroidism causes a hypocoagulable state that can be successfully assessed by ROTEM. Hemostatic changes, do not seem to have an effect on increased cardiovascular mortality.Key words: Hyperparathyroidism, coagulation, thromboelastogram, ROTEM

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Yorulmaz G, Kalkan A, AKALIN A, Alagüney E, GUNDUZ E, Badak B, Aydin Buyruk B, Kebapci M, EFE F, Bilgin M, akay o (2021). Effect of hyperparathyroidism on coagulation: a global assessment by modified rotation thromboelastogram (ROTEM). , 2897 - 2902. 10.3906/sag-2012-247
Chicago	Yorulmaz Goknur,Kalkan Ahmet Toygar,AKALIN AYSEN,Alagüney Elif Sevil,GUNDUZ Eren,Badak Bartu,Aydin Buyruk Betul,Kebapci Medine Nur,EFE FATMA BELGIN,Bilgin Muzaffer,akay olga meltem Effect of hyperparathyroidism on coagulation: a global assessment by modified rotation thromboelastogram (ROTEM). (2021): 2897 - 2902. 10.3906/sag-2012-247
MLA	Yorulmaz Goknur,Kalkan Ahmet Toygar,AKALIN AYSEN,Alagüney Elif Sevil,GUNDUZ Eren,Badak Bartu,Aydin Buyruk Betul,Kebapci Medine Nur,EFE FATMA BELGIN,Bilgin Muzaffer,akay olga meltem Effect of hyperparathyroidism on coagulation: a global assessment by modified rotation thromboelastogram (ROTEM). , 2021, ss.2897 - 2902. 10.3906/sag-2012-247
AMA	Yorulmaz G,Kalkan A,AKALIN A,Alagüney E,GUNDUZ E,Badak B,Aydin Buyruk B,Kebapci M,EFE F,Bilgin M,akay o Effect of hyperparathyroidism on coagulation: a global assessment by modified rotation thromboelastogram (ROTEM). . 2021; 2897 - 2902. 10.3906/sag-2012-247
Vancouver	Yorulmaz G,Kalkan A,AKALIN A,Alagüney E,GUNDUZ E,Badak B,Aydin Buyruk B,Kebapci M,EFE F,Bilgin M,akay o Effect of hyperparathyroidism on coagulation: a global assessment by modified rotation thromboelastogram (ROTEM). . 2021; 2897 - 2902. 10.3906/sag-2012-247
IEEE	Yorulmaz G,Kalkan A,AKALIN A,Alagüney E,GUNDUZ E,Badak B,Aydin Buyruk B,Kebapci M,EFE F,Bilgin M,akay o "Effect of hyperparathyroidism on coagulation: a global assessment by modified rotation thromboelastogram (ROTEM)." , ss.2897 - 2902, 2021. 10.3906/sag-2012-247
ISNAD	Yorulmaz, Goknur vd. "Effect of hyperparathyroidism on coagulation: a global assessment by modified rotation thromboelastogram (ROTEM)". (2021), 2897-2902. https://doi.org/10.3906/sag-2012-247

APA	Yorulmaz G, Kalkan A, AKALIN A, Alagüney E, GUNDUZ E, Badak B, Aydin Buyruk B, Kebapci M, EFE F, Bilgin M, akay o (2021). Effect of hyperparathyroidism on coagulation: a global assessment by modified rotation thromboelastogram (ROTEM). Turkish Journal of Medical Sciences, 51(6), 2897 - 2902. 10.3906/sag-2012-247
Chicago	Yorulmaz Goknur,Kalkan Ahmet Toygar,AKALIN AYSEN,Alagüney Elif Sevil,GUNDUZ Eren,Badak Bartu,Aydin Buyruk Betul,Kebapci Medine Nur,EFE FATMA BELGIN,Bilgin Muzaffer,akay olga meltem Effect of hyperparathyroidism on coagulation: a global assessment by modified rotation thromboelastogram (ROTEM). Turkish Journal of Medical Sciences 51, no.6 (2021): 2897 - 2902. 10.3906/sag-2012-247
MLA	Yorulmaz Goknur,Kalkan Ahmet Toygar,AKALIN AYSEN,Alagüney Elif Sevil,GUNDUZ Eren,Badak Bartu,Aydin Buyruk Betul,Kebapci Medine Nur,EFE FATMA BELGIN,Bilgin Muzaffer,akay olga meltem Effect of hyperparathyroidism on coagulation: a global assessment by modified rotation thromboelastogram (ROTEM). Turkish Journal of Medical Sciences, vol.51, no.6, 2021, ss.2897 - 2902. 10.3906/sag-2012-247
AMA	Yorulmaz G,Kalkan A,AKALIN A,Alagüney E,GUNDUZ E,Badak B,Aydin Buyruk B,Kebapci M,EFE F,Bilgin M,akay o Effect of hyperparathyroidism on coagulation: a global assessment by modified rotation thromboelastogram (ROTEM). Turkish Journal of Medical Sciences. 2021; 51(6): 2897 - 2902. 10.3906/sag-2012-247
Vancouver	Yorulmaz G,Kalkan A,AKALIN A,Alagüney E,GUNDUZ E,Badak B,Aydin Buyruk B,Kebapci M,EFE F,Bilgin M,akay o Effect of hyperparathyroidism on coagulation: a global assessment by modified rotation thromboelastogram (ROTEM). Turkish Journal of Medical Sciences. 2021; 51(6): 2897 - 2902. 10.3906/sag-2012-247
IEEE	Yorulmaz G,Kalkan A,AKALIN A,Alagüney E,GUNDUZ E,Badak B,Aydin Buyruk B,Kebapci M,EFE F,Bilgin M,akay o "Effect of hyperparathyroidism on coagulation: a global assessment by modified rotation thromboelastogram (ROTEM)." Turkish Journal of Medical Sciences, 51, ss.2897 - 2902, 2021. 10.3906/sag-2012-247
ISNAD	Yorulmaz, Goknur vd. "Effect of hyperparathyroidism on coagulation: a global assessment by modified rotation thromboelastogram (ROTEM)". Turkish Journal of Medical Sciences 51/6 (2021), 2897-2902. https://doi.org/10.3906/sag-2012-247