TY  - JOUR
TI  - Distal spread and tumor regression patterns following preoperative chemoradiotherapy in rectal cancer patients
AB  - Background/aim: This study aimed to evaluate the regression pattern with the distal intramural spread (DIS) of rectum cancer after preoperative chemoradiation. Materials and methods: Specimens from 56 patients who underwent radical resection after preoperative chemoradiation for rectal cancer were examined. The regression pattern (total, fragmented) of the tumor was recorded. DIS status was evaluated by creating sections 0.2 to 0.3 cm thick. Results: A single macroscopic residual area was detected in all specimens. In 10 patients (17.8 %), pathologically complete responses were identified, and DIS was detected in 33 patients (58.9%). The average DIS distance was 0.56 ± 0.3 cm (range 0.2 – 1.8 cm); the spread was < 1 cm in 87.9% of the patients (29/33). The overall survival rates for 5 and 7 years were 76.8% and 73.2%, respectively. The survival rates between patients with and without DIS were not statistically different (94.6 ± 5.5 vs. 75.1 ± 10.2 months, respectively). In all of the patients, tumor regression pattern was total shrinkage of the tumor. Conclusion: A sufficient distal resection margin for rectal cancer after preoperative chemoradiation is 1 cm in the vast majority of cases. However, DIS may exceed 1 cm in a small proportion of patients.Key words: Rectum cancer, neoadjuvant therapy, resection margin
AU  - Akoglu, Musa
AU  - cayci, haci murat
AU  - Dalgic, Tahsin
AU  - zengin, neslihan inci
AU  - yuksel, adem
AU  - Bostanci, Erdal Birol
AU  - Ozer, ilter
AU  - Ulas, Murat
DO  - 10.3906/sag-2007-102
PY  - 2021
JO  - Turkish Journal of Medical Sciences
VL  - 51
IS  - 6
SN  - 1300-0144
SP  - 2978
EP  - 2985
DB  - TRDizin
UR  - http://search/yayin/detay/477679
ER  -