Yıl: 2021 Cilt: 51 Sayı: 6 Sayfa Aralığı: 3001 - 3007 Metin Dili: İngilizce DOI: 10.3906/sag-2007-87 İndeks Tarihi: 05-01-2022

Frequency of peripheral blood eosinophilia and obstructive airway disease in sarcoidosis

Öz:
Background/aim: There is limited information about peripheral blood eosinophilia (PBE) and airway obstruction in sarcoidosis. Since pulmonary sarcoidosis affects the airways, it is often confused with asthma. The aims of the study are to investigate airway obstruction and PBE in sarcoidosis patients and to examine the similarity of clinical presentation with asthma. Materials and methods: The patients matching the ATS/ERS/WASOG diagnosis criteria and were between 18 and 80 years of age were included consecutively between 2018 and 2020. Other diseases causing granulomas were excluded. Results: A total of 84 patients were included of which 26 (31%) had a PBE level of ≥300 µL with no significant difference seen between sarcoidosis stage and PBE (p > 0.05). A significant (p < 0.05) decrease was only seen in FEV1 as the stage of sarcoidosis progressed. Respectively 31 (36.9%), 12 (14.3%) and 4 (4.8%) patients had an obstructive, restrictive and mixed respiratory function disorder. Twenty-four (28.6%) subjects with sarcoidosis had history of asthma. Spring fever, eczema, and skin/nose allergy were noticed in 17 (20.2%) of the patients. Conclusion: Mild PBE may be seen in sarcoidosis. Patients applying with PBE, airway obstruction, bronchial hyperreactivity along with spring fever, eczema, skin/nose allergy, wheezing, chest tightness, shortness of breath and cough may be also evaluated in terms of sarcoidosis.Key words: Airway obstruction, asthma, eosinophilia, sarcoidosis
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  • 1. Statement on sarcoidosis. Joint statement of the American thoracic society (ATS), the European respiratory society (ERS) and the world association of sarcoidosis and other granulomatous disorders (WASOG) adopted by the ATS board of directors and by the ERS executive committee.American Journal of Respiratory and Critical Care Medicine1999;160:736–755.doi: 10.1164/ajrccm.160.2.ats4-99
  • 2. Rybicki BA, Maliarik MJ, Major M, Popovich J Jr, Iannuzzi MC. Epidemiology, demographics, and genetics of sarcoidosis. Seminars in Respiratory Infections 1998;13(3):166-173.PMID: 9764947.
  • 3. Bresnitz EA, Strom BL. Epidemiology of sarcoidosis.Epidemiologic Reviews 1983; 5:124-56.doi: 10.1093/oxfordjournals.epirev. a036255
  • 4. Wiman LG. Familial occurrence of sarcoidosis.Scandinavian Journal of Respiratory DiseaseSupplementum1972; 80:115-9. PMID: 4510908.
  • 5. Danila E, Jurgauskiené V, Malickaité R. BAL fluid cells and pulmonary function in different radiographic stages of newly diagnosed sarcoidosis. Advances in Medical Science 2008; 53:228-233.doi: 10.2478/v10039-008-0014-z
  • 6. AhlstedtS, Murray CS. In vitro diagnosis of allergy: how to interpret IgE antibody results in clinical practice. Primary Care Respiratory Journal 2006; 15:228-36. doi: 10.1016/j. pcrj.2006.05.004
  • 7. Olsson T, Björnstad-Pettersen H, Stjernberg NL. Bronchostenosis due to sarcoidosis: a cause of atelectasis and airway obstruction simulating pulmonary neoplasm and chronic obstructive pulmonary disease. Chest 1979; 75:663–666.doi: 10.1378/ chest.75.6.663
  • 8. Hadfield JW, Page RL, Flower CD, StarkJ E. Localised airway narrowing in sarcoidosis.Thorax Journal 1982; 37:443–447. doi: 10.1136/thx.37.6.443
  • 9. Westcott JL, Noehren TH. Bronchial stenosis in chronic sarcoidosis. Chest 1973; 63:893–897.doi: 10.1378/chest.63.6.893
  • 10. Abehsera M, Valeyre D, Grenier P, H Jaillet, BattestiJ P,BraunerM W. Sarcoidosis with pulmonary fibrosis: CT patterns and correlation with pulmonary function. American Journal of Roentgenology 2000; 174:1751–1757.doi: 10.2214/ ajr.174.6.1741751
  • 11. Mihailovic VV, Zugic V, Videnovic I J. New observations on pulmonary function changes in sarcoidosis. Current Opinion in Pulmonary Medicine 2003; 9:436–441.doi: 10.1097/00063198- 200309000-00017
  • 12. Marcias S, Ledda MA, Perra R, Severino C, Rosetti L. A specific bronchial hyperreactivity in pulmonary sarcoidosis. Sarcoidosis 1994; 11:118–122. PMID: 7809495.
  • 13. Bechtel JJ, Starr T 3rd, Dantzker DR, Bower JS. Airway hyperreactivity in patients with sarcoidosis. The American Review of Respiratory Disease 1981; 124:759–761.
  • 14. Rissmiller RW, Ennis WJ. Pulmonary function testing and sarcoidosis: a review. Lung Breath Journal, 2018; 2: 1-5.doi: 10.15761/LBJ.1000121
  • 15. Miller A, Teirstein AS, Jackler I et al. Airway function in chronic pulmonary sarcoidosis with fibrosis. The American Review of Respiratory Disease 1974; 109:179–189.doi: 10.1164/ arrd.1974.109.2.179
  • 16. Lower EE, Smith JT, Martelo OJ, Baughman RP. The anemia of sarcoidosis. Sarcoidosis 1988;5(1):51-55. PMID: 3381019.
  • 17. Lamberto C, Nunes H, LeToumelin P, Duperron F, Valeyre D, Clerici C.Membrane and capillary blood components of diffusion capacity of the lung for carbon monoxide in pulmonary sarcoidosis: relation to exercise gas exchange. Chest 2004; 125:2061-2068.doi:10.1378/chest.125.6.2061
  • 18. Chusid MJ, Dale DC, West BC, Wolff SM . The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature. Medicine 1975; 54: 1–27. PMID: 1090795.
  • 19. Butt NM, Lambert J, Ali S,Beer PA, Cross NCP, et al. Guideline for the investigation and management of eosinophilia. British Journal of Haematology 2017; 176: 553–572.doi: 10.1111/ bjh.14488
  • 20. Yuhanisa A, NurShuhaila S, Heselynn H, MohdShahrir Mohamed S. Case review of sarcoidosis resembling sjogren’s syndrome. Journal of Clinical Medical Research 2010;2:284- 288.doi: 10.4021/jocmr482w
  • 21. Siltzbach LE, James DG, Neville E, Turiaf J, Battesti JP, et al. Course and prognosis of sarcoidosis around the world. The American Journal of Medicine 1974; 57:847–852.doi: 10.1016/0002- 9343(74)90160-0
  • 22. Abo-Leyah H, Finch S, Keir H, Fardon T, Chalmers J. Peripheral blood eosinophilia and clinical phenotype in Bronchiectasis. European Respiratory Journal 2018; 52 (62):2665. doi: 10.1183/13993003.congress-2018
  • 23. Prins HJ, Duijkers R, Lutter R, Daniels JM, Valk PVDet al. Blood eosinophilia as a marker of early and late treatment failure in severe acute exacerbations of COPD.Respiratory Medicine 2017; 131:118-124.doi: 10.1016/j.rmed.2017.07.064
  • 24. Wilsher M, Hopkins R, Zeng I,Cornere M, Douglas R. Prevalence of asthma and atopy in sarcoidosis. Official Journal of the Asian Pacific Society of Respirology 2012; 17: 285–290.doi: 10.1111/j.1440-1843.2011.02066.x
  • 25. Crane J, Lewis S, Slater T,Crossland L, Robson B et al. The self reported prevalence of asthma symptoms amongst adult New Zealanders. New Zealand Medical Journal 1994; 107: 417–21. PMID: 7970336.
  • 26. Burney PG, Luczynska C, Chinn S,Jarvis D. The European community respiratory health survey.European Respiratory Journal1994; 7: 954–60.doi:10.1183/09031936.94.07050954
  • 27. Renston JP, Goldman ES, Hsu RM, Tomashefski J F Jr. Peripheral blood eosinophilia in association with sarcoidosis. Mayo Clinic Proceedings 2000; 75:586.doi: 10.4065/75.6.586
  • 28. Takahashi A, Konno S,Hatanaka K,Matsuno Y, Yamaguchi E et al. A case of sarcoidosis with eosinophilia in peripheral blood and bronchoalveolar lavage fluid. Respiratory Medicine Case Reports 2013; 8: 43-46.doi: 10.1016/j.rmcr.2013.01.004
  • 29. Aleksonienė R, Zeleckienė I, Matačiūnas M, Puronaitė R, Jurgauskienė Let al. Relationship between radiologic patterns, pulmonary function values and bronchoalveolar lavage fluid cells in newly diagnosed sarcoidosis. Journal of Thoracic Disease 2017; 9:88-95.doi: 10.21037/jtd.2017.01.17
  • 30. Chenivesse C, Boulanger S, Langlois C, Wemeau-Stervinou L,Perez Tet al. Oxygen desaturation during a 6-minute walk test as a predictor of maximal exercise-induced gas exchange abnormalities in sarcoidosis. Journal of Thoracic Disease 2016; 8:1995-2003.doi: 10.21037/jtd.2016.06.39
  • 31. Kalkanis A, Judson MA. Distinguishing Asthma from Sarcoidosis: An Approach to a Problem that is not Always Solvable. Journal of Asthma 2013; 50: 1–6.doi: 10.3109/02770903.2012.747204
  • 32. Tomohiro H, Sonoko N, Yasutaka F, Shinji M, Kosuke Oet al. Clinical and radiographic indices associated with airflow limitation in patients with sarcoidosis. Chest 2006; 130:1851– 1856. doi:10.1378/chest.130.6.1851
APA RABAHOĞLU B, OYMAK f, baran ketencioğlu b, tutar n, gülmez i, Yilmaz I (2021). Frequency of peripheral blood eosinophilia and obstructive airway disease in sarcoidosis. , 3001 - 3007. 10.3906/sag-2007-87
Chicago RABAHOĞLU BİLAL,OYMAK fatma,baran ketencioğlu burcu,tutar nuri,gülmez inci,Yilmaz Insu Frequency of peripheral blood eosinophilia and obstructive airway disease in sarcoidosis. (2021): 3001 - 3007. 10.3906/sag-2007-87
MLA RABAHOĞLU BİLAL,OYMAK fatma,baran ketencioğlu burcu,tutar nuri,gülmez inci,Yilmaz Insu Frequency of peripheral blood eosinophilia and obstructive airway disease in sarcoidosis. , 2021, ss.3001 - 3007. 10.3906/sag-2007-87
AMA RABAHOĞLU B,OYMAK f,baran ketencioğlu b,tutar n,gülmez i,Yilmaz I Frequency of peripheral blood eosinophilia and obstructive airway disease in sarcoidosis. . 2021; 3001 - 3007. 10.3906/sag-2007-87
Vancouver RABAHOĞLU B,OYMAK f,baran ketencioğlu b,tutar n,gülmez i,Yilmaz I Frequency of peripheral blood eosinophilia and obstructive airway disease in sarcoidosis. . 2021; 3001 - 3007. 10.3906/sag-2007-87
IEEE RABAHOĞLU B,OYMAK f,baran ketencioğlu b,tutar n,gülmez i,Yilmaz I "Frequency of peripheral blood eosinophilia and obstructive airway disease in sarcoidosis." , ss.3001 - 3007, 2021. 10.3906/sag-2007-87
ISNAD RABAHOĞLU, BİLAL vd. "Frequency of peripheral blood eosinophilia and obstructive airway disease in sarcoidosis". (2021), 3001-3007. https://doi.org/10.3906/sag-2007-87
APA RABAHOĞLU B, OYMAK f, baran ketencioğlu b, tutar n, gülmez i, Yilmaz I (2021). Frequency of peripheral blood eosinophilia and obstructive airway disease in sarcoidosis. Turkish Journal of Medical Sciences, 51(6), 3001 - 3007. 10.3906/sag-2007-87
Chicago RABAHOĞLU BİLAL,OYMAK fatma,baran ketencioğlu burcu,tutar nuri,gülmez inci,Yilmaz Insu Frequency of peripheral blood eosinophilia and obstructive airway disease in sarcoidosis. Turkish Journal of Medical Sciences 51, no.6 (2021): 3001 - 3007. 10.3906/sag-2007-87
MLA RABAHOĞLU BİLAL,OYMAK fatma,baran ketencioğlu burcu,tutar nuri,gülmez inci,Yilmaz Insu Frequency of peripheral blood eosinophilia and obstructive airway disease in sarcoidosis. Turkish Journal of Medical Sciences, vol.51, no.6, 2021, ss.3001 - 3007. 10.3906/sag-2007-87
AMA RABAHOĞLU B,OYMAK f,baran ketencioğlu b,tutar n,gülmez i,Yilmaz I Frequency of peripheral blood eosinophilia and obstructive airway disease in sarcoidosis. Turkish Journal of Medical Sciences. 2021; 51(6): 3001 - 3007. 10.3906/sag-2007-87
Vancouver RABAHOĞLU B,OYMAK f,baran ketencioğlu b,tutar n,gülmez i,Yilmaz I Frequency of peripheral blood eosinophilia and obstructive airway disease in sarcoidosis. Turkish Journal of Medical Sciences. 2021; 51(6): 3001 - 3007. 10.3906/sag-2007-87
IEEE RABAHOĞLU B,OYMAK f,baran ketencioğlu b,tutar n,gülmez i,Yilmaz I "Frequency of peripheral blood eosinophilia and obstructive airway disease in sarcoidosis." Turkish Journal of Medical Sciences, 51, ss.3001 - 3007, 2021. 10.3906/sag-2007-87
ISNAD RABAHOĞLU, BİLAL vd. "Frequency of peripheral blood eosinophilia and obstructive airway disease in sarcoidosis". Turkish Journal of Medical Sciences 51/6 (2021), 3001-3007. https://doi.org/10.3906/sag-2007-87