TY  - JOUR
TI  - A novel marker of systemic inflammation in psoriasis and related comorbidities: chitotriosidase
AB  - Background/aim: Chitotriosidase (ChT) is an enzyme secreted by activated macrophages and neutrophils in response to proinflammatory signals. There is growing evidence indicating that ChT activity reflects the systemic inflammatory status. This study aimed to investigate whether serum ChT activity increased in patients with psoriasis and related comorbidities. Materials and methods: This cross-sectional study included 53 (28 with associated comorbidities and 25 without comorbidities) patients with psoriasis and 52 healthy volunteers. All participants underwent laboratory investigations for serum ChT levels, complete blood count, erythrocyte sedimentation rate, C-reactive protein, and serum lipid levels. Results: The patients with psoriasis showed significantly higher levels of ChT activity as compared to the healthy controls (23.5 ± 11.4 vs. 17.5 ± 10.4 μmol/mL/hour; p = 0.015). Additionally, the ChT activity was significantly higher in patients with comorbidities than in those without (p = 0.042). Conclusion: Our data support the pathogenetic role of inflammatory processes induced by macrophage activation in patients with psoriasis and related comorbidities. We believe that high ChT activity in patients with psoriasis may serve as an early prediction of the possible related comorbidities.Keywords: Chitotriosidase, comorbidity, macrophage, psoriasis
AU  - Y. Sozmen, Eser
AU  - Elmas, Ömer Faruk
AU  - Demirbaş, Abdullah
AU  - LOTTI, TORELLO
AU  - Günay, Ümran
AU  - ilanbey, Bilal
AU  - Atasoy, Mustafa
AU  - tursen, umit
DO  - 10.3906/sag-2101-137
PY  - 2021
JO  - Turkish Journal of Medical Sciences
VL  - 51
IS  - 5
SN  - 1300-0144
SP  - 2318
EP  - 2323
DB  - TRDizin
UR  - http://search/yayin/detay/478912
ER  -