Yıl: 2021 Cilt: 51 Sayı: 5 Sayfa Aralığı: 2351 - 2356 Metin Dili: İngilizce DOI: 10.3906/sag-2103-127 İndeks Tarihi: 06-01-2022

Central nervous system involvement in patients with acute myeloid leukemia

Öz:
Background/aim: To evaluate the incidence, clinical features, risk factors, and prognosis of central nervous system (CNS) involvement in patients with acute myeloid leukemia (AML). Materials and methods: All AML patients who were admitted to Hacettepe University hospital between 2000 and 2021 were evaluated. The medical records of 548 AML cases were retrospectively analyzed. Results: The frequency of CNS involvement was 2.4% (n = 13) at diagnosis and 4.6% (n = 25) at diagnosis or during follow-up. Parenchymal involvement was seen in 5 patients, leptomeningeal involvement was seen in 11 patients. Three patients had both leptomeningeal and parenchymal involvements, and 6 patients had optic nerve or ocular involvement. In univariate analysis, younger age and extramedullary involvement at diagnosis were associated with CNS disease at diagnosis, and extramedullary involvement at diagnosis was associated with CNS disease during follow-up. In multivariate analysis; younger age and extramedullary involvement at diagnosis were associated with CNS disease at diagnosis and during follow-up respectively. Median overall survival was 5.4 months in patients with CNS disease at diagnosis and 16.9 months in patients with CNS disease during follow-up and 16.2 months in patients with no CNS disease. Conclusion: CNS disease is a rare complication of AML. Younger age and extramedullary involvement at diagnosis are risk factors for CNS involvement.Keywords: Acute myeloid leukemia, central nervous system involvement, risk factors
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APA Yasar H, Çınar O, Yazdali N, Barista I, Göker H, Buyukasik Y (2021). Central nervous system involvement in patients with acute myeloid leukemia. , 2351 - 2356. 10.3906/sag-2103-127
Chicago Yasar Hatime,Çınar Olgu Erkin,Yazdali Nur,Barista Ibrahim,Göker Hakan,Buyukasik Yahya Central nervous system involvement in patients with acute myeloid leukemia. (2021): 2351 - 2356. 10.3906/sag-2103-127
MLA Yasar Hatime,Çınar Olgu Erkin,Yazdali Nur,Barista Ibrahim,Göker Hakan,Buyukasik Yahya Central nervous system involvement in patients with acute myeloid leukemia. , 2021, ss.2351 - 2356. 10.3906/sag-2103-127
AMA Yasar H,Çınar O,Yazdali N,Barista I,Göker H,Buyukasik Y Central nervous system involvement in patients with acute myeloid leukemia. . 2021; 2351 - 2356. 10.3906/sag-2103-127
Vancouver Yasar H,Çınar O,Yazdali N,Barista I,Göker H,Buyukasik Y Central nervous system involvement in patients with acute myeloid leukemia. . 2021; 2351 - 2356. 10.3906/sag-2103-127
IEEE Yasar H,Çınar O,Yazdali N,Barista I,Göker H,Buyukasik Y "Central nervous system involvement in patients with acute myeloid leukemia." , ss.2351 - 2356, 2021. 10.3906/sag-2103-127
ISNAD Yasar, Hatime vd. "Central nervous system involvement in patients with acute myeloid leukemia". (2021), 2351-2356. https://doi.org/10.3906/sag-2103-127
APA Yasar H, Çınar O, Yazdali N, Barista I, Göker H, Buyukasik Y (2021). Central nervous system involvement in patients with acute myeloid leukemia. Turkish Journal of Medical Sciences, 51(5), 2351 - 2356. 10.3906/sag-2103-127
Chicago Yasar Hatime,Çınar Olgu Erkin,Yazdali Nur,Barista Ibrahim,Göker Hakan,Buyukasik Yahya Central nervous system involvement in patients with acute myeloid leukemia. Turkish Journal of Medical Sciences 51, no.5 (2021): 2351 - 2356. 10.3906/sag-2103-127
MLA Yasar Hatime,Çınar Olgu Erkin,Yazdali Nur,Barista Ibrahim,Göker Hakan,Buyukasik Yahya Central nervous system involvement in patients with acute myeloid leukemia. Turkish Journal of Medical Sciences, vol.51, no.5, 2021, ss.2351 - 2356. 10.3906/sag-2103-127
AMA Yasar H,Çınar O,Yazdali N,Barista I,Göker H,Buyukasik Y Central nervous system involvement in patients with acute myeloid leukemia. Turkish Journal of Medical Sciences. 2021; 51(5): 2351 - 2356. 10.3906/sag-2103-127
Vancouver Yasar H,Çınar O,Yazdali N,Barista I,Göker H,Buyukasik Y Central nervous system involvement in patients with acute myeloid leukemia. Turkish Journal of Medical Sciences. 2021; 51(5): 2351 - 2356. 10.3906/sag-2103-127
IEEE Yasar H,Çınar O,Yazdali N,Barista I,Göker H,Buyukasik Y "Central nervous system involvement in patients with acute myeloid leukemia." Turkish Journal of Medical Sciences, 51, ss.2351 - 2356, 2021. 10.3906/sag-2103-127
ISNAD Yasar, Hatime vd. "Central nervous system involvement in patients with acute myeloid leukemia". Turkish Journal of Medical Sciences 51/5 (2021), 2351-2356. https://doi.org/10.3906/sag-2103-127