Assessment of fragmented QRS formation and its relationship with left ventricular hypertrophy in nonhypertensive acromegaly patients

Kebapci, Medine  Nur; mert, kadir ugur; dural, muhammet; Yılmaz, Ahmet Serdar; Çamlı, Ezgi; Kalkan, Ahmet Toygar; Yorulmaz, Goknur; AKALIN, AYSEN; MURAT, Selda; Alagüney, Elif Sevil; EFE, FATMA BELGIN

doi:10.3906/sag-2101-229

Assessment of fragmented QRS formation and its relationship with left ventricular hypertrophy in nonhypertensive acromegaly patients

Muhammet DURAL, (Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Eskişehir, Türkiye)

Goknur YORULMAZ, (Eskişehir Osmangazi Üniversitesi, Endokrinoloji Anabilim Dalı, Tıp Fakültesi, Eskişehir, Türkiye)

Elif Sevil ALAGÜNEY, (Konya Eğitim ve Araştırma Hastanesi, Endokrinoloji Anabilim Dalı, Konya, Türkiye)

Kadir Uğur MERT, (Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Eskişehir, Türkiye)

Ezgi ÇAMLI, (Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Eskişehir, Türkiye)

Ahmet Toygar KALKAN, (Eskişehir Osmangazi Üniversitesi, Endokrinoloji Anabilim Dalı, Tıp Fakültesi, Eskişehir, Türkiye)

Aysen AKALIN, (Eskişehir Osmangazi Üniversitesi, Endokrinoloji Anabilim Dalı, Tıp Fakültesi, Eskişehir, Türkiye)

Medine Nur KEBAPÇI, (Eskişehir Osmangazi Üniversitesi, Endokrinoloji Anabilim Dalı, Tıp Fakültesi, Eskişehir, Türkiye)

Ahmet Serdar YILMAZ, (Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Eskişehir, Türkiye)

Selda MURAT, (Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Eskişehir, Türkiye)

Fatma Belgin EFE, (Eskişehir Osmangazi Üniversitesi, Endokrinoloji Anabilim Dalı, Tıp Fakültesi, Eskişehir, Türkiye)

Diğer Yazarlar

Turkish Journal of Medical Sciences

0 1

Yıl: 2021 Cilt: 51 Sayı: 5 Sayfa Aralığı: 2437 - 2444 Metin Dili: İngilizce DOI: 10.3906/sag-2101-229 İndeks Tarihi: 07-01-2022

Assessment of fragmented QRS formation and its relationship with left ventricular hypertrophy in nonhypertensive acromegaly patients

Öz:

Background/aim: It is known that the presence of fragmented QRS (fQRS) on electrocardiography (ECG) is associated with cardiovascular events. The aim of this study was the evaluation of fQRS formation and its relationship with the left ventricular hypertrophy (LVH) parameters in acromegaly patients. Materials and methods: In total, 47 previously diagnosed with non-hypertensive acromegaly patients and 48 control subjects were included in the study. ECG and transthoracic echocardiography (TTE) were performed for each participant. Acromegaly patients were divided into two groups according to the fQRS formation on the ECG. Left ventricular wall thicknesses, and left atrial diameter (LAD), left ventricular mass (LVM), left ventricular mass index (LVMi), and relative wall thickness (RWT) were obtained. Results: In control group 5 (10.4%) and in acromegaly group 17 (36.2%) patients had fQRS on ECG (p = 0.003). LAD [36.0 (34.0–38.0) vs. 38.0 (35.0–41.0) mm, p < 0.001], LVM [155.27 ± 27.00 vs. 173.0 (153.0–235.0) g, p < 0.001], LVMi [83.12 ± 13.19 vs. 92.0 (83.0–118.0) g/m², p < 0.001] and RWT [0.39 ± 0.03 vs. 0.43 (0.41–0.45), p = 0.001] were significantly higher in patients with acromegaly. Disease duration was significantly higher (11.59 ± 1.3 vs. 8.2 ± 1.8 years, p < 0.001) in the fQRS (+) group. LAD [41.0 (39.0–42.5) vs. 37.0 (34.7– 38.0) mm, p < 0.001], LVM [219.0 (160.5–254.5) vs. 164.0 (153.0–188.0) g, p = 0.017], LVMi [117.0 (92.5–128.5) vs. 86.0 (82.0–100.2) g/m², p = 0.013] and RWT [0.44 (0.42–0.49) vs. 0.43 (0.40–0.44), p = 0.037] were significantly higher in fQSR (+) acromegaly patients. In multivariate logistic regression analysis, disease duration (odds ratio: 10.05, 95% CI: 1.099–92.012, p = 0.041) and LAD (odds ratio: 2.19, 95% CI: 1.030–4.660, p = 0.042) were found to be the independent predictors of fQRS formation. Conclusion: The results of our study revealed that fQRS (+) acromegaly patients had increased LVH parameters compared to fQRS (-) patients.Key words: Acromegaly, fragmented QRS, left ventricular hypertrophy, left ventricular mass

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	dural m, Yorulmaz G, Alagüney E, mert k, Çamlı E, Kalkan A, AKALIN A, Kebapci M, Yılmaz A, MURAT S, EFE F (2021). Assessment of fragmented QRS formation and its relationship with left ventricular hypertrophy in nonhypertensive acromegaly patients. , 2437 - 2444. 10.3906/sag-2101-229
Chicago	dural muhammet,Yorulmaz Goknur,Alagüney Elif Sevil,mert kadir ugur,Çamlı Ezgi,Kalkan Ahmet Toygar,AKALIN AYSEN,Kebapci Medine Nur,Yılmaz Ahmet Serdar,MURAT Selda,EFE FATMA BELGIN Assessment of fragmented QRS formation and its relationship with left ventricular hypertrophy in nonhypertensive acromegaly patients. (2021): 2437 - 2444. 10.3906/sag-2101-229
MLA	dural muhammet,Yorulmaz Goknur,Alagüney Elif Sevil,mert kadir ugur,Çamlı Ezgi,Kalkan Ahmet Toygar,AKALIN AYSEN,Kebapci Medine Nur,Yılmaz Ahmet Serdar,MURAT Selda,EFE FATMA BELGIN Assessment of fragmented QRS formation and its relationship with left ventricular hypertrophy in nonhypertensive acromegaly patients. , 2021, ss.2437 - 2444. 10.3906/sag-2101-229
AMA	dural m,Yorulmaz G,Alagüney E,mert k,Çamlı E,Kalkan A,AKALIN A,Kebapci M,Yılmaz A,MURAT S,EFE F Assessment of fragmented QRS formation and its relationship with left ventricular hypertrophy in nonhypertensive acromegaly patients. . 2021; 2437 - 2444. 10.3906/sag-2101-229
Vancouver	dural m,Yorulmaz G,Alagüney E,mert k,Çamlı E,Kalkan A,AKALIN A,Kebapci M,Yılmaz A,MURAT S,EFE F Assessment of fragmented QRS formation and its relationship with left ventricular hypertrophy in nonhypertensive acromegaly patients. . 2021; 2437 - 2444. 10.3906/sag-2101-229
IEEE	dural m,Yorulmaz G,Alagüney E,mert k,Çamlı E,Kalkan A,AKALIN A,Kebapci M,Yılmaz A,MURAT S,EFE F "Assessment of fragmented QRS formation and its relationship with left ventricular hypertrophy in nonhypertensive acromegaly patients." , ss.2437 - 2444, 2021. 10.3906/sag-2101-229
ISNAD	dural, muhammet vd. "Assessment of fragmented QRS formation and its relationship with left ventricular hypertrophy in nonhypertensive acromegaly patients". (2021), 2437-2444. https://doi.org/10.3906/sag-2101-229

APA	dural m, Yorulmaz G, Alagüney E, mert k, Çamlı E, Kalkan A, AKALIN A, Kebapci M, Yılmaz A, MURAT S, EFE F (2021). Assessment of fragmented QRS formation and its relationship with left ventricular hypertrophy in nonhypertensive acromegaly patients. Turkish Journal of Medical Sciences, 51(5), 2437 - 2444. 10.3906/sag-2101-229
Chicago	dural muhammet,Yorulmaz Goknur,Alagüney Elif Sevil,mert kadir ugur,Çamlı Ezgi,Kalkan Ahmet Toygar,AKALIN AYSEN,Kebapci Medine Nur,Yılmaz Ahmet Serdar,MURAT Selda,EFE FATMA BELGIN Assessment of fragmented QRS formation and its relationship with left ventricular hypertrophy in nonhypertensive acromegaly patients. Turkish Journal of Medical Sciences 51, no.5 (2021): 2437 - 2444. 10.3906/sag-2101-229
MLA	dural muhammet,Yorulmaz Goknur,Alagüney Elif Sevil,mert kadir ugur,Çamlı Ezgi,Kalkan Ahmet Toygar,AKALIN AYSEN,Kebapci Medine Nur,Yılmaz Ahmet Serdar,MURAT Selda,EFE FATMA BELGIN Assessment of fragmented QRS formation and its relationship with left ventricular hypertrophy in nonhypertensive acromegaly patients. Turkish Journal of Medical Sciences, vol.51, no.5, 2021, ss.2437 - 2444. 10.3906/sag-2101-229
AMA	dural m,Yorulmaz G,Alagüney E,mert k,Çamlı E,Kalkan A,AKALIN A,Kebapci M,Yılmaz A,MURAT S,EFE F Assessment of fragmented QRS formation and its relationship with left ventricular hypertrophy in nonhypertensive acromegaly patients. Turkish Journal of Medical Sciences. 2021; 51(5): 2437 - 2444. 10.3906/sag-2101-229
Vancouver	dural m,Yorulmaz G,Alagüney E,mert k,Çamlı E,Kalkan A,AKALIN A,Kebapci M,Yılmaz A,MURAT S,EFE F Assessment of fragmented QRS formation and its relationship with left ventricular hypertrophy in nonhypertensive acromegaly patients. Turkish Journal of Medical Sciences. 2021; 51(5): 2437 - 2444. 10.3906/sag-2101-229
IEEE	dural m,Yorulmaz G,Alagüney E,mert k,Çamlı E,Kalkan A,AKALIN A,Kebapci M,Yılmaz A,MURAT S,EFE F "Assessment of fragmented QRS formation and its relationship with left ventricular hypertrophy in nonhypertensive acromegaly patients." Turkish Journal of Medical Sciences, 51, ss.2437 - 2444, 2021. 10.3906/sag-2101-229
ISNAD	dural, muhammet vd. "Assessment of fragmented QRS formation and its relationship with left ventricular hypertrophy in nonhypertensive acromegaly patients". Turkish Journal of Medical Sciences 51/5 (2021), 2437-2444. https://doi.org/10.3906/sag-2101-229