TY  - JOUR
TI  - Can omentin-1 be a prognostic marker in surgical intensive care patients?
AB  - Background/aim: A member of the adipokine family, omentin-1 is selectively secreted from visceral fat tissue and the omentum. It has been shown that omentin-1 is involved in the pathogenesis of certain diseases and can be used as a prognostic marker. This study first investigated the prognostic significance of omentin-1 in surgical intensive care patients. In addition, the relationship between omentin-1 and laboratory and clinical parameters commonly used in intensive care units (ICUs) was evaluated. Materials and methods: One hundred and fifty-four patients hospitalized in the surgical ICU were included in the study. Blood samples for omentin-1 were collected from the patients displaying clinical condition changes. Changes in omentin-1 levels were observed during the hospital stay of the patients. A total of 423 blood samples were evaluated. Omentin-1 levels were compared to the laboratory parameters routinely monitored in the ICU and the prognostic significance of omentin-1 for surgical intensive care patients was investigated. Results: The median APACHE II score of all patients was (median-IQR, 8.0–6.0 ng/mL). Omentin-1 levels of the alive patients in the ICU (median-IQR, 339.04–407.68 ng/mL) were significantly higher compared to dead patients (median-IQR, 166.40–363.60 ng/ mL). Omentin-1 levels were higher in nonsepsis patients compared to the levels of the patients in sepsis and septic shock (p < 0.001). Omentin-1 values were negatively correlated with the C-reactive protein and procalcitonin levels, body temperature, and the SOFA (sequential organ failure assessment score) scores and they were positively correlated with albumin, prealbumin, and glucose levels. Conclusion: Omentin-1 may play a role in the complex constructs of inflammation and metabolic events in intensive care patients. Reduced omentin-1 levels in surgical intensive care patients were associated with poor prognosis and increased mortality.Key words: Intensive care, omentin, prognostic marker
AU  - Kilic, Yusuf Alper
AU  - Portakal, Oytun
AU  - Biri, İsmail
AU  - gultekin, yucel
AU  - Gojayev, Afig
AU  - Yilmaz Isikhan, Selen
DO  - 10.3906/sag-2009-158
PY  - 2021
JO  - Turkish Journal of Medical Sciences
VL  - 51
IS  - 5
SN  - 1300-0144
SP  - 2485
EP  - 2493
DB  - TRDizin
UR  - http://search/yayin/detay/479143
ER  -