TY  - JOUR
TI  - A nationwide retrospective study in Turkish children with nephrocalcinosis
AB  - Background/aim: Nephrocalcinosis (NC) is defined as calcium deposition in the kidney parenchyma and tubules. This study aims to determine the etiology, risk factors, and follow-up results of patients with NC in Turkey. Materials and methods: Patients diagnosed with NC in the pediatric nephrology Department Units of 19 centers from all geographical regions of Turkey over a 10-year period (2010–2019) were included in the study. The medical records from the centers were reviewed and demographic data, admission complaints, medical history, systemic and genetic disorders, risk factors for NC, treatment details, and presence of NC after one-year follow-up, were recorded retrospectively. Results: The study sample included 195 patients (88 females, 107 males). The mean age at diagnosis was 39.44 ± 47.25 (0.5–208) months; 82/190 patients (43.2%) were diagnosed incidentally; 46/195 patients (23.6%) had an underlying disease; idiopathic hypercalciuria was detected in 75/195 (38.4%) patients. The most common systemic diseases were distal renal tubular acidosis in 11/46 patients (23.9%), primary hyperoxaluria in 9/46 patients (19.6%) and Bartter syndrome in 7/46 patients (15.3%). After one year of follow-up, NC resolved in 56/159 patients (35.2%) and they all did not have an underlying systemic disease. Conclusion: The most common presentation of NC was incidental. Distal renal tubular acidosis and primary hyperoxaluria were the main systemic diseases leading to NC, while hypercalciuria was the most common metabolic risk factor. Nephrocalcinosis was found to remain in most of the patients at a one-year follow-up. It may resolve particularly in patients with no underlying systemic disease.Keywords: Bartter syndrome, hypercalciuria, nephrocalcinosis, renal tubular acidosis
AU  - Elmacı, Ahmet Midhat
AU  - Çomak, Elif
AU  - Bıyıklı, Neşe
AU  - Hacıhamdioğlu, Duygu Övünç
AU  - Karabag yilmaz, Esra
AU  - Yel, Sibel
AU  - Gunay, Neslihan
AU  - Atmış, Bahriye
AU  - Özdemir Atikel, Yeşim
AU  - yavas aksu, bagdagul
AU  - Çam delebe, Emine özlem
AU  - Yilmaz, Alev
AU  - celik, binnaz
AU  - Baştuğ, Funda
AU  - Ertan, Pelin
AU  - Gökce, İbrahim
AU  - Cicek, neslihan
AU  - Küçük, Nuran
AU  - Nalcacioglu, Hulya
AU  - Sever, Fatma lale
AU  - Ağbaş, Ayşe
AU  - Tülpar, Sebahat
AU  - YAZICIOĞLU, Burcu
AU  - Yuruk Yildirim, Zeynep
AU  - Dursun, Ismail
AU  - Sürmeli Döven, Serra
AU  - Delibaş, Ali
AU  - Öner, Nimet
AU  - Gemici, Atilla
AU  - ALPAY, HARİKA
AU  - AKMAN, Sema
AU  - Uysal, Berfin
DO  - 10.3906/sag-2103-347
PY  - 2021
JO  - Turkish Journal of Medical Sciences
VL  - 51
IS  - 5
SN  - 1300-0144
SP  - 2564
EP  - 2569
DB  - TRDizin
UR  - http://search/yayin/detay/479280
ER  -