TY  - JOUR
TI  - Genetic Polymorphisms in Turkish Patients with Lumbar Disk Herniation
AB  - Lumbar disc herniation (LDH) defined in the early 1930s and has since been treated, is the most common disease group in which neurosurgeons have dealt with and performed operations. The pathogenesis of this disease is still unknown. The study aimed to evaluate any potential contribution of disease-associated single nucleotide gene polymorphisms (SNPs) in LDH etiology. Male and female volunteers with LDH participated in the study. All variants (SOD1 IVS3+35 A>C); SOD2 c.*3409T>A; c.*441A>G; MTHFR p.Ala222Val (c.677C>T), and PAI-1-844G>A) were analysed using polymerase chain reaction and restriction fragment length polymorphism (PCR–RFLP) method. In MTHFR 677C>T, “T” additive model and “T” dominant model, CC vs. CT (OR:5.69 Cl: 2.4-13.4 p<0.001) and CC vs. TC+TT(OR:5.69 Cl: 2.4-13.4 p<0.001) increased the risk of LDH almost 6-fold, “C” recessive model, CT+TT vs. CC (OR:5.68 Cl:2.4-13.5 p<0.001) reduced the risk of LDH almost 6-fold while others were not associated with LDH. In a paired analysis of MTHFRc.677C>T/PAI-1-844G>A genotypes, it was determined that AG genotype increased the protective effect of CC genotype (CC+AG vs others) of the MTHFR gene (OR: 8.4 Cl:2.2-3.1 P<0.001) while reducing the negative effect of the TC genotype of MTHFR gene(TC+AG vs others) in LDH risk(OR: 4.4 Cl: 1.5-12.1P=0.005). A similar result was not determined for the investigated SOD1 and SOD2 variants. For the first time, in our study groups, MTHFR677C>T polymorphism was found associated with an increased risk of LDH.
AU  - Ekinci, Bilge
AU  - Özener, Barış
AU  - Polat, Seher
AU  - ARSLAN, YUSUF KEMAL
DO  - 10.18185/erzifbed.881338
PY  - 2021
JO  - Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi
VL  - 14
IS  - 2
SN  - 1307-9085
SP  - 472
EP  - 491
DB  - TRDizin
UR  - http://search/yayin/detay/479552
ER  -