TY  - JOUR
TI  - Autoimmunity in psoriatic arthritis: pathophysiological and clinical aspects
AB  - Abstract: Psoriatic arthritis (PsA) is an underdiagnosed entity with a broad impact on the quality of life. Although the pathogenesis is largely unknown, autoimmune footprints of the inflammation in PsA have increasingly been recognized. Most of the genetic variation predisposing to PsA is mapped to the class I major histocompatibility complex (MHC) region and shared by a variety of autoimmune diseases. Polymorphisms in the genes IL12B, IL23R, IL13, TNIP1, TRAF3IP2, TYK2, and many others explain the nonHLA genetic risk with little known functional consequences. Entheseal and synovial cellular infiltrate with oligoclonal CD8+ T cells and occasional germinal centers, loss of regulatory T cell function, and specific autoantibodies such as anti-PsA peptide, anti-LL-37, and anti-ADAMTSL5 are the immunopathological findings suggestive of autoimmunity. These were supported by clinical observations of autoimmune multimorbidity and treatment response to calcineurin/mTOR and co-stimulation inhibition.Key words: Autoantibody, autoimmunity, genetic, psoriasis, psoriatic arthritis
AU  - Direskeneli, Haner
AU  - emmungil, hakan
AU  - İlgen, Ufuk
DO  - 10.3906/sag-2011-235
PY  - 2021
JO  - Turkish Journal of Medical Sciences
VL  - 51
IS  - 4
SN  - 1300-0144
SP  - 1601
EP  - 1614
DB  - TRDizin
UR  - http://search/yayin/detay/479700
ER  -