Reference values for T and B lymphocyte subpopulations in Turkish children and adults

Background/aim: Established reference values are critical for the interpretation of immunologic assessments. In particular, the proportion and absolute counts of T- and B- cell subpopulations are subject to change with age and ethnicity. We aimed to establish agespecific reference values for lymphocyte subsets using updated immunophenotyping panels. Materials and methods: We studied a total of 297 healthy Turkish subjects aged 0 to 50 years, stratified into major age brackets in a cluster factor of 10 per age-group. The predetermined age intervals contained randomly allocated participants enrolled over a period of 6 months, who were homogenously distributed by sex. We analyzed a complete blood count test and simultaneously with detailed immunophenotyping enumerated the percent and absolute cell counts of lymphocyte subsets. Results: The percentage and absolute counts of lymphocyte subsets show a marked surge across the age-span. T helper, T cytotoxic, and the natural killer cell numbers were increasing from birth until 6 months, followed by a gradual decrease thereafter. B cell numbers were rising until 2 years, followed by a gradual decrease for the upcoming years, accompanied by a steady expansion of unclass-switched- and class-switched- B cells. Conclusion: We provide updated extensive reference intervals for lymphocyte subpopulations in Turkish people.Key words: Immunophenotyping, lymphocyte subsets, reference values, lymphocyte percentage, absolute count

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Besci O, BAŞER D, OGULUR I, BERBEROĞLU A, Kiykim A, Besci T, Leblebici A, Ellidokuz H, Boran P, Ozek E, Haklar G, ÖZER A, Baris S, Karakoc-Aydiner E (2021). Reference values for T and B lymphocyte subpopulations in Turkish children and adults. , 1814 - 1824. 10.3906/sag-2010-176
Chicago	Besci Ozge,BAŞER Dilek,OGULUR ISMAIL,BERBEROĞLU Ayşe Cansu,Kiykim Ayca,Besci Tolga,Leblebici Asım,Ellidokuz Hülya,Boran Perran,Ozek Eren,Haklar Goncagul,ÖZER Ahmet,Baris Safa,Karakoc-Aydiner Elif Reference values for T and B lymphocyte subpopulations in Turkish children and adults. (2021): 1814 - 1824. 10.3906/sag-2010-176
MLA	Besci Ozge,BAŞER Dilek,OGULUR ISMAIL,BERBEROĞLU Ayşe Cansu,Kiykim Ayca,Besci Tolga,Leblebici Asım,Ellidokuz Hülya,Boran Perran,Ozek Eren,Haklar Goncagul,ÖZER Ahmet,Baris Safa,Karakoc-Aydiner Elif Reference values for T and B lymphocyte subpopulations in Turkish children and adults. , 2021, ss.1814 - 1824. 10.3906/sag-2010-176
AMA	Besci O,BAŞER D,OGULUR I,BERBEROĞLU A,Kiykim A,Besci T,Leblebici A,Ellidokuz H,Boran P,Ozek E,Haklar G,ÖZER A,Baris S,Karakoc-Aydiner E Reference values for T and B lymphocyte subpopulations in Turkish children and adults. . 2021; 1814 - 1824. 10.3906/sag-2010-176
Vancouver	Besci O,BAŞER D,OGULUR I,BERBEROĞLU A,Kiykim A,Besci T,Leblebici A,Ellidokuz H,Boran P,Ozek E,Haklar G,ÖZER A,Baris S,Karakoc-Aydiner E Reference values for T and B lymphocyte subpopulations in Turkish children and adults. . 2021; 1814 - 1824. 10.3906/sag-2010-176
IEEE	Besci O,BAŞER D,OGULUR I,BERBEROĞLU A,Kiykim A,Besci T,Leblebici A,Ellidokuz H,Boran P,Ozek E,Haklar G,ÖZER A,Baris S,Karakoc-Aydiner E "Reference values for T and B lymphocyte subpopulations in Turkish children and adults." , ss.1814 - 1824, 2021. 10.3906/sag-2010-176
ISNAD	Besci, Ozge vd. "Reference values for T and B lymphocyte subpopulations in Turkish children and adults". (2021), 1814-1824. https://doi.org/10.3906/sag-2010-176

APA	Besci O, BAŞER D, OGULUR I, BERBEROĞLU A, Kiykim A, Besci T, Leblebici A, Ellidokuz H, Boran P, Ozek E, Haklar G, ÖZER A, Baris S, Karakoc-Aydiner E (2021). Reference values for T and B lymphocyte subpopulations in Turkish children and adults. Turkish Journal of Medical Sciences, 51(4), 1814 - 1824. 10.3906/sag-2010-176
Chicago	Besci Ozge,BAŞER Dilek,OGULUR ISMAIL,BERBEROĞLU Ayşe Cansu,Kiykim Ayca,Besci Tolga,Leblebici Asım,Ellidokuz Hülya,Boran Perran,Ozek Eren,Haklar Goncagul,ÖZER Ahmet,Baris Safa,Karakoc-Aydiner Elif Reference values for T and B lymphocyte subpopulations in Turkish children and adults. Turkish Journal of Medical Sciences 51, no.4 (2021): 1814 - 1824. 10.3906/sag-2010-176
MLA	Besci Ozge,BAŞER Dilek,OGULUR ISMAIL,BERBEROĞLU Ayşe Cansu,Kiykim Ayca,Besci Tolga,Leblebici Asım,Ellidokuz Hülya,Boran Perran,Ozek Eren,Haklar Goncagul,ÖZER Ahmet,Baris Safa,Karakoc-Aydiner Elif Reference values for T and B lymphocyte subpopulations in Turkish children and adults. Turkish Journal of Medical Sciences, vol.51, no.4, 2021, ss.1814 - 1824. 10.3906/sag-2010-176
AMA	Besci O,BAŞER D,OGULUR I,BERBEROĞLU A,Kiykim A,Besci T,Leblebici A,Ellidokuz H,Boran P,Ozek E,Haklar G,ÖZER A,Baris S,Karakoc-Aydiner E Reference values for T and B lymphocyte subpopulations in Turkish children and adults. Turkish Journal of Medical Sciences. 2021; 51(4): 1814 - 1824. 10.3906/sag-2010-176
Vancouver	Besci O,BAŞER D,OGULUR I,BERBEROĞLU A,Kiykim A,Besci T,Leblebici A,Ellidokuz H,Boran P,Ozek E,Haklar G,ÖZER A,Baris S,Karakoc-Aydiner E Reference values for T and B lymphocyte subpopulations in Turkish children and adults. Turkish Journal of Medical Sciences. 2021; 51(4): 1814 - 1824. 10.3906/sag-2010-176
IEEE	Besci O,BAŞER D,OGULUR I,BERBEROĞLU A,Kiykim A,Besci T,Leblebici A,Ellidokuz H,Boran P,Ozek E,Haklar G,ÖZER A,Baris S,Karakoc-Aydiner E "Reference values for T and B lymphocyte subpopulations in Turkish children and adults." Turkish Journal of Medical Sciences, 51, ss.1814 - 1824, 2021. 10.3906/sag-2010-176
ISNAD	Besci, Ozge vd. "Reference values for T and B lymphocyte subpopulations in Turkish children and adults". Turkish Journal of Medical Sciences 51/4 (2021), 1814-1824. https://doi.org/10.3906/sag-2010-176