TY  - JOUR
TI  - Evaluation of extensively drug-resistant gram-negative bacteremia among solid-organ transplant recipients: a multicenter study
AB  - Background/aim: The aim of this study is to evaluate the distribution, sources, clinical features, and mortality rates of bacteremia due to evaluation of extensively drug-resistant (XDR) gram negative among solid-organ transplant (SOT) recipients. Materials and methods: A retrospective study of SOT recipients with bacteremia due to XDR gram-negative pathogens in 11 centers between 2016 and 2018 was conducted. Patients’ records were evaluated. Results: Of 171 bacteremia that occurred in 164 SOT recipients, 93 (56.7%) were liver, 46 (28%) kidney, 14 (8.5%) heart, and 11 (6.7%) lung recipients. Bacteremia episodes were recorded in the first year in 63.7% of the patients (n = 109), early-onset bacteremia was recorded in 45% (n = 77) of the episodes. In multivariate analysis, catheter-associated bacteremia was an independent risk factor for 7-day mortality (p = 0.037), and early-onset bacteremia was found as an independent risk factor for 30-day mortality (p = 0.017). Conclusion: Difficult-to-treat infections due to XDR bacteria in SOT recipients shadow the success of transplantation. Central venous catheters seem to be the main risk factor. Judicious use of medical devices is of pivotal importance.Key words: Solid-organ transplant recipients, drug-resistant, bacteremia
AU  - CINAR, GULE
AU  - demir önder, kübra
AU  - yanık yalçın, tuğba
AU  - Azap, Özlem Kurt
AU  - Haberal, Mehmet
AU  - ARI, ALPAY
AU  - EREN-KUTSOYLU, Oya Ozlem
AU  - GUZEL TUNCCAN, OZLEM
AU  - Köse, Adem
AU  - ÖZTÜRK DENİZ, SUNA SEÇİL
AU  - Albayrak, Yurdagül
AU  - Ozger, H.Selcuk
AU  - Tezer-Tekçe, A.Yasemin
AU  - Sarıcaoğlu, Elif mukime
AU  - BAYINDIR, Yasar
AU  - Oruc, Ebru
AU  - Kizilates, Filiz
AU  - Çabadak, Hatice
AU  - ALISKAN, HIKMET EDA
AU  - Uygun Kizmaz, Yesim
AU  - Egeli, Tufan
DO  - 10.3906/sag-2101-161
PY  - 2021
JO  - Turkish Journal of Medical Sciences
VL  - 51
IS  - 4
SN  - 1300-0144
SP  - 1960
EP  - 1968
DB  - TRDizin
UR  - http://search/yayin/detay/480657
ER  -