Yıl: 2021 Cilt: 11 Sayı: 2 Sayfa Aralığı: 324 - 329 Metin Dili: İngilizce DOI: 10.33808/clinexphealthsci.798527

Oxidative Stress in Controlled Hypotension: Assessment with a Novel Oxidative Stress Marker

Öz:
Objective: The aim of this study was to evaluate the effects of oxidative stress on thiol-disulfide homeostasis caused by hypotensive anesthesia in mastoidectomy-tympanoplasty cases undergoing controlled hypotension. Methods: Fifty adult patients scheduled for mastoidectomy and tympanoplasty were included in the study. Anesthesia was induced with lidocaine, propofol, rocuronium, and remifentanil. The maintenance of anesthesia was continued with remifentanil infusion (target mean arterial pressure as 60-65 mmHg) along with 2% sevoflurane/40% O2/air mixture. Blood samples were taken 5 times at the t0 (before induction), t1 (intraoperatively after intubation), t2 (first hour) and t3 (second hour of the operation) and t4 (following recovery). Total thiol (TT) and Native Thiol (NT) levels were measured, and thus, Di-Sulphide (SS), Di-Sulphide/Native Thiol (SSNT), Di-Sulphide/Total Thiol (SSTT), and Native Thiol/ Total Thiol (NTTT) values were estimated. Results: During the operation, progressive decrease was observed in thiol levels of patients. There was a significant decrease in t3 thiol values when compared with t0 value. Thiol values were observed to have returned to baseline values after recovery from anesthesia (p>0.05). SS, SSNT and SSTT levels were found as increased in t1 blood samples, but increase in SSNT and SSTT levels was significant. Throughout the operation, values were observed to have dropped and reverted back to initial values. Conclusion: Since the measurement of thiol-disulfide blood values is able to show the instantaneous state of oxidative stress, it can be used in anesthesia practice in which every event occurs very quickly.
Anahtar Kelime:

Konular:
Fen > Tıp > Tıbbi İnformatik
Fen > Tıp > Tıbbi Araştırmalar Deneysel
Fen > Tıp > Temel Sağlık Hizmetleri
Fen > Tıp > Halk ve Çevre Sağlığı
Fen > Tıp > Sağlık Bilimleri ve Hizmetleri
Fen > Tıp > Genel ve Dahili Tıp
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA DOGER C, OZCAN A, ERKİLİC E, ELLİK S, AKSOY M, ALIŞIK M, EREL Ö (2021). Oxidative Stress in Controlled Hypotension: Assessment with a Novel Oxidative Stress Marker. Clinical and Experimental Health Sciences, 11(2), 324 - 329. 10.33808/clinexphealthsci.798527
Chicago DOGER Cihan,OZCAN Ayca Tuba Dumanli,ERKİLİC Ezgi,ELLİK Suleyman,AKSOY Mustafa,ALIŞIK Murat,EREL Özcan Oxidative Stress in Controlled Hypotension: Assessment with a Novel Oxidative Stress Marker. Clinical and Experimental Health Sciences 11, no.2 (2021): 324 - 329. 10.33808/clinexphealthsci.798527
MLA DOGER Cihan,OZCAN Ayca Tuba Dumanli,ERKİLİC Ezgi,ELLİK Suleyman,AKSOY Mustafa,ALIŞIK Murat,EREL Özcan Oxidative Stress in Controlled Hypotension: Assessment with a Novel Oxidative Stress Marker. Clinical and Experimental Health Sciences, vol.11, no.2, 2021, ss.324 - 329. 10.33808/clinexphealthsci.798527
AMA DOGER C,OZCAN A,ERKİLİC E,ELLİK S,AKSOY M,ALIŞIK M,EREL Ö Oxidative Stress in Controlled Hypotension: Assessment with a Novel Oxidative Stress Marker. Clinical and Experimental Health Sciences. 2021; 11(2): 324 - 329. 10.33808/clinexphealthsci.798527
Vancouver DOGER C,OZCAN A,ERKİLİC E,ELLİK S,AKSOY M,ALIŞIK M,EREL Ö Oxidative Stress in Controlled Hypotension: Assessment with a Novel Oxidative Stress Marker. Clinical and Experimental Health Sciences. 2021; 11(2): 324 - 329. 10.33808/clinexphealthsci.798527
IEEE DOGER C,OZCAN A,ERKİLİC E,ELLİK S,AKSOY M,ALIŞIK M,EREL Ö "Oxidative Stress in Controlled Hypotension: Assessment with a Novel Oxidative Stress Marker." Clinical and Experimental Health Sciences, 11, ss.324 - 329, 2021. 10.33808/clinexphealthsci.798527