The study of Tau and phospho Tau protein levels in attention deficit and hyperactivity disorder

Saracoglu, Hatice; Demirci, Esra; Kılıç, eser

doi:10.3906/sag-2012-198

The study of Tau and phospho Tau protein levels in attention deficit and hyperactivity disorder

Hatice SARAÇOĞLU, (Erciyes Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Kayseri, Türkiye)

Eser KILIÇ, (Erciyes Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Kayseri, Türkiye)

Esra DEMİRCİ (Erciyes Üniversitesi, Tıp Fakültesi, Çocuk ve Ergen Psikiyatrisi Anabilim Dalı, Kayseri, Türkiye)

Turkish Journal of Medical Sciences

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Yıl: 2021 Cilt: 51 Sayı: 4 Sayfa Aralığı: 2107 - 2111 Metin Dili: İngilizce DOI: 10.3906/sag-2012-198 İndeks Tarihi: 14-01-2022

The study of Tau and phospho Tau protein levels in attention deficit and hyperactivity disorder

Öz:

Background/aim: Attention deficit and hyperactivity disorder (ADHD) is a widespread neurodevelopmental disorder that begins in childhood and has negative consequences throughout adult life. The etiology and pathogenesis of ADHD are still unclear. Tau protein is a soluble microtubule-related protein expressed by neurons and localized in the cytoplasm as well as axons. Tau protein provides stability of microtubule in two ways: phosphorylation and isoforms. The excessive phosphorylation of Tau separates the protein from the microtubule, thus making it unstable. In this study, we aimed to investigate whether there is a relationship between serum Tau protein and phospho Tau (p-Tau181) levels and ADHD occurrence. Materials and methods: This study included 26 male children aged 7–12 years with newly diagnosed ADHD, who had previously not used any medication for ADHD, and 26 male healthy children. Serum Tau and p-Tau181 concentrations were performed by enzymelinked immunosorbent assay (ELISA). Results: In patients, the Tau levels were not significantly different from those of the controls; the p-Tau181 levels were significantly higher than those of the controls. Conclusion: We concluded that high p-Tau181 might be associated with the progression of ADHD and cognitive changes in ADHD.Key words: Attention deficit and hyperactivity disorder, Tau, phospho Tau

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Saracoglu H, Kılıç e, Demirci E (2021). The study of Tau and phospho Tau protein levels in attention deficit and hyperactivity disorder. , 2107 - 2111. 10.3906/sag-2012-198
Chicago	Saracoglu Hatice,Kılıç eser,Demirci Esra The study of Tau and phospho Tau protein levels in attention deficit and hyperactivity disorder. (2021): 2107 - 2111. 10.3906/sag-2012-198
MLA	Saracoglu Hatice,Kılıç eser,Demirci Esra The study of Tau and phospho Tau protein levels in attention deficit and hyperactivity disorder. , 2021, ss.2107 - 2111. 10.3906/sag-2012-198
AMA	Saracoglu H,Kılıç e,Demirci E The study of Tau and phospho Tau protein levels in attention deficit and hyperactivity disorder. . 2021; 2107 - 2111. 10.3906/sag-2012-198
Vancouver	Saracoglu H,Kılıç e,Demirci E The study of Tau and phospho Tau protein levels in attention deficit and hyperactivity disorder. . 2021; 2107 - 2111. 10.3906/sag-2012-198
IEEE	Saracoglu H,Kılıç e,Demirci E "The study of Tau and phospho Tau protein levels in attention deficit and hyperactivity disorder." , ss.2107 - 2111, 2021. 10.3906/sag-2012-198
ISNAD	Saracoglu, Hatice vd. "The study of Tau and phospho Tau protein levels in attention deficit and hyperactivity disorder". (2021), 2107-2111. https://doi.org/10.3906/sag-2012-198

APA	Saracoglu H, Kılıç e, Demirci E (2021). The study of Tau and phospho Tau protein levels in attention deficit and hyperactivity disorder. Turkish Journal of Medical Sciences, 51(4), 2107 - 2111. 10.3906/sag-2012-198
Chicago	Saracoglu Hatice,Kılıç eser,Demirci Esra The study of Tau and phospho Tau protein levels in attention deficit and hyperactivity disorder. Turkish Journal of Medical Sciences 51, no.4 (2021): 2107 - 2111. 10.3906/sag-2012-198
MLA	Saracoglu Hatice,Kılıç eser,Demirci Esra The study of Tau and phospho Tau protein levels in attention deficit and hyperactivity disorder. Turkish Journal of Medical Sciences, vol.51, no.4, 2021, ss.2107 - 2111. 10.3906/sag-2012-198
AMA	Saracoglu H,Kılıç e,Demirci E The study of Tau and phospho Tau protein levels in attention deficit and hyperactivity disorder. Turkish Journal of Medical Sciences. 2021; 51(4): 2107 - 2111. 10.3906/sag-2012-198
Vancouver	Saracoglu H,Kılıç e,Demirci E The study of Tau and phospho Tau protein levels in attention deficit and hyperactivity disorder. Turkish Journal of Medical Sciences. 2021; 51(4): 2107 - 2111. 10.3906/sag-2012-198
IEEE	Saracoglu H,Kılıç e,Demirci E "The study of Tau and phospho Tau protein levels in attention deficit and hyperactivity disorder." Turkish Journal of Medical Sciences, 51, ss.2107 - 2111, 2021. 10.3906/sag-2012-198
ISNAD	Saracoglu, Hatice vd. "The study of Tau and phospho Tau protein levels in attention deficit and hyperactivity disorder". Turkish Journal of Medical Sciences 51/4 (2021), 2107-2111. https://doi.org/10.3906/sag-2012-198