TY  - JOUR
TI  - Is CONUT score a prognostic index in patients with diffuse large cell lymphoma?
AB  - Background/aim: The aim of the study was to evaluate the effect of Controlling Nutritional Status (CONUT) score on the prognosis in patients with diffuse large B-cell lymphoma (DLBCL). Materials and methods: The present study was a retrospective study. The CONUT score was calculated based on serum albumin, total cholesterol and lymphocyte levels. This study included a total of 266 patients, 131 (49.2%) were female and 135 (50.8%) were male. The median follow-up period was 51 months (range: 1–190). Results: The median age was 64 years. The cut off CONUT was 1.5. There was a significant difference between patients with high (≥ 2) or low (< 2) CONUT scores in terms of overall survival (OS) and progression-free survival (PFS). The 5-year OS and PFS in patients with high CONUT score was 52.1% and 49.7%. The 5-year OS and PFS in patients with low CONUT score was 79.8% and 75.6% (p < 0.001). In the multivariate analysis for OS, age ≥ 65 years (HR = 1.80, p = 0.028), Eastern Cooperative Oncology Group (ECOG) > 1 (HR = 2.04, p = 0.006), stage IIIA–IVB disease (HR = 2.75, p = 0.001) and the CONUT score (HR = 1.15, p = 0.003) were found statistically significant. In the multivariate analysis for PFS, age ≥ 65 years (HR = 2.02, p = 0.007), stage IIIA–IVB disease (HR = 2.42, p = 0.002) and the CONUT score (HR = 1.19, p = 0.001) were found to be significant parameters. Conclusion: High CONUT score reduces OS and PFS in DLBCL. CONUT score is an independent, strong prognostic index in patients with DLBCL. Key words: Lymphoma, Controlling Nutritional Status score, survival, prognosis
AU  - SENOL, HANDE
AU  - nar, rukiye
AU  - Hacioglu, Sibel
AU  - Erol, Veysel
AU  - bozdemir, aslı
AU  - ŞEN TÜRK, Nilay
AU  - ilkkilic, kadir
AU  - Güler, Nil
AU  - Akgun Cagliyan, Gulsum
AU  - ÜNVER KOLUMAN, BAŞAK
AU  - YILDIRIM, ONURCAN
AU  - Cagliyan, Omer
AU  - Baser, Mehmet Nuri
DO  - 10.3906/sag-2101-406
PY  - 2021
JO  - Turkish Journal of Medical Sciences
VL  - 51
IS  - 4
SN  - 1300-0144
SP  - 2112
EP  - 2119
DB  - TRDizin
UR  - http://search/yayin/detay/481005
ER  -