Possible antiapoptotic and neuroprotective effects of magnesium sulphate on retina in a preterm hypoxic-ischemic rat model

YALIN IMAMOGLU, EBRU; USLU, UNAL; Cumbul, Alev; Erdenöz, Serkan; AKTAŞ, ŞAMİL; Ovalı, Hüsnü Fahri; Imamoglu, Serhat

doi:10.3906/sag-2012-119

Possible antiapoptotic and neuroprotective effects of magnesium sulphate on retina in a preterm hypoxic-ischemic rat model

Serhat İMAMOĞLU, (Sağlık Bilimleri Üniversitesi, Haydarpaşa Numune Eğitim ve Araştırma Hastanesi, Göz Hastalıkları Anabilim Dalı, İstanbul, Türkiye)

Ebru YALIN İMAMOĞLU, (İstanbul Medeniyet Üniversitesi, Göztepe Eğitim ve Araştırma Hastanesi, Neonatoloji Anabilim Dalı, İstanbul, Türkiye)

Serkan ERDENOZ, (Sağlık Bilimleri Üniversitesi, Okmeydanı Eğitim ve Araştırma Hastanesi, Göz Hastalıkları Anabilim Dalı, İstanbul, Türkiye)

Alev CUMBUL, (Yeditepe Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, İstanbul, Türkiye)

Ünal USLU, (İstanbul Medeniyet Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, İstanbul, Türkiye)

Şamil AKTAŞ, (İstanbul Üniversitesi, Tıp Fakültesi Denizaltı ve Hiperbarik Tıp Anabilim Dalı, İstanbul, Türkiye)

Fahri OVALI (İstanbul Medeniyet Üniversitesi, Göztepe Eğitim ve Araştırma Hastanesi, Neonatoloji Anabilim Dalı, İstanbul, Türkiye)

Turkish Journal of Medical Sciences

1 0

Yıl: 2021 Cilt: 51 Sayı: 4 Sayfa Aralığı: 2198 - 2205 Metin Dili: İngilizce DOI: 10.3906/sag-2012-119 İndeks Tarihi: 14-01-2022

Possible antiapoptotic and neuroprotective effects of magnesium sulphate on retina in a preterm hypoxic-ischemic rat model

Öz:

Background/aim: The effects of systemic magnesium sulfate (MgSO4) on retina in preterm hypoxic-ischemic (HI) rat model are not known. Our aim was to investigate the effects of MgSO4on retinal ganglion cell (RGC) count, retinal ganglion cell (RGC) apoptotic index, retinal vascular endothelial growth factor receptor-2 (VEGFR-2), and glial fibrillary acidic protein (GFAP) expressions in preterm HI rat model. Materials and methods: Fifteen, postnatal day (PND) 7 rat pups were divided into 3 groups: 1. Sham-operated group, 2. HI group, and 3. MgSO4 -treated HI group. The second and third groups underwent ischemia followed by exposure to hypoxia for 2 h (Vannucci model). The first and second groups received intraperitoneal saline and the third group received intraperitoneal MgSO4 . On PND 10, eyes of the pups were evaluated for RGC count, apoptotic index, VEGFR-2, and GFAP expressions. Results: In both HI and MgSO4 -treated HI group, the mean total RGC counts were found to be significantly decreased. However, the mean total RGC count in the MgSO4 -treated HI group was significantly higher than that of the HI group. The mean apoptotic index was found to be significantly increased in the HI group. Retinal VEGFR-2 and GFAP expressions were found to be significantly higher in the HI group. Conclusions: Magnesium sulfate preconditioning andtreatment in preterm HI rat model might diminish apoptosis, relatively preserve RGCs, and reduce retinal VEGFR-2 and GFAP expressions.Key words: Hypoxia-ischemia, magnesium sulfate, neuroprotection, retina

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Imamoglu S, YALIN IMAMOGLU E, Erdenöz S, Cumbul A, USLU U, AKTAŞ Ş, Ovalı H (2021). Possible antiapoptotic and neuroprotective effects of magnesium sulphate on retina in a preterm hypoxic-ischemic rat model. , 2198 - 2205. 10.3906/sag-2012-119
Chicago	Imamoglu Serhat,YALIN IMAMOGLU EBRU,Erdenöz Serkan,Cumbul Alev,USLU UNAL,AKTAŞ ŞAMİL,Ovalı Hüsnü Fahri Possible antiapoptotic and neuroprotective effects of magnesium sulphate on retina in a preterm hypoxic-ischemic rat model. (2021): 2198 - 2205. 10.3906/sag-2012-119
MLA	Imamoglu Serhat,YALIN IMAMOGLU EBRU,Erdenöz Serkan,Cumbul Alev,USLU UNAL,AKTAŞ ŞAMİL,Ovalı Hüsnü Fahri Possible antiapoptotic and neuroprotective effects of magnesium sulphate on retina in a preterm hypoxic-ischemic rat model. , 2021, ss.2198 - 2205. 10.3906/sag-2012-119
AMA	Imamoglu S,YALIN IMAMOGLU E,Erdenöz S,Cumbul A,USLU U,AKTAŞ Ş,Ovalı H Possible antiapoptotic and neuroprotective effects of magnesium sulphate on retina in a preterm hypoxic-ischemic rat model. . 2021; 2198 - 2205. 10.3906/sag-2012-119
Vancouver	Imamoglu S,YALIN IMAMOGLU E,Erdenöz S,Cumbul A,USLU U,AKTAŞ Ş,Ovalı H Possible antiapoptotic and neuroprotective effects of magnesium sulphate on retina in a preterm hypoxic-ischemic rat model. . 2021; 2198 - 2205. 10.3906/sag-2012-119
IEEE	Imamoglu S,YALIN IMAMOGLU E,Erdenöz S,Cumbul A,USLU U,AKTAŞ Ş,Ovalı H "Possible antiapoptotic and neuroprotective effects of magnesium sulphate on retina in a preterm hypoxic-ischemic rat model." , ss.2198 - 2205, 2021. 10.3906/sag-2012-119
ISNAD	Imamoglu, Serhat vd. "Possible antiapoptotic and neuroprotective effects of magnesium sulphate on retina in a preterm hypoxic-ischemic rat model". (2021), 2198-2205. https://doi.org/10.3906/sag-2012-119

APA	Imamoglu S, YALIN IMAMOGLU E, Erdenöz S, Cumbul A, USLU U, AKTAŞ Ş, Ovalı H (2021). Possible antiapoptotic and neuroprotective effects of magnesium sulphate on retina in a preterm hypoxic-ischemic rat model. Turkish Journal of Medical Sciences, 51(4), 2198 - 2205. 10.3906/sag-2012-119
Chicago	Imamoglu Serhat,YALIN IMAMOGLU EBRU,Erdenöz Serkan,Cumbul Alev,USLU UNAL,AKTAŞ ŞAMİL,Ovalı Hüsnü Fahri Possible antiapoptotic and neuroprotective effects of magnesium sulphate on retina in a preterm hypoxic-ischemic rat model. Turkish Journal of Medical Sciences 51, no.4 (2021): 2198 - 2205. 10.3906/sag-2012-119
MLA	Imamoglu Serhat,YALIN IMAMOGLU EBRU,Erdenöz Serkan,Cumbul Alev,USLU UNAL,AKTAŞ ŞAMİL,Ovalı Hüsnü Fahri Possible antiapoptotic and neuroprotective effects of magnesium sulphate on retina in a preterm hypoxic-ischemic rat model. Turkish Journal of Medical Sciences, vol.51, no.4, 2021, ss.2198 - 2205. 10.3906/sag-2012-119
AMA	Imamoglu S,YALIN IMAMOGLU E,Erdenöz S,Cumbul A,USLU U,AKTAŞ Ş,Ovalı H Possible antiapoptotic and neuroprotective effects of magnesium sulphate on retina in a preterm hypoxic-ischemic rat model. Turkish Journal of Medical Sciences. 2021; 51(4): 2198 - 2205. 10.3906/sag-2012-119
Vancouver	Imamoglu S,YALIN IMAMOGLU E,Erdenöz S,Cumbul A,USLU U,AKTAŞ Ş,Ovalı H Possible antiapoptotic and neuroprotective effects of magnesium sulphate on retina in a preterm hypoxic-ischemic rat model. Turkish Journal of Medical Sciences. 2021; 51(4): 2198 - 2205. 10.3906/sag-2012-119
IEEE	Imamoglu S,YALIN IMAMOGLU E,Erdenöz S,Cumbul A,USLU U,AKTAŞ Ş,Ovalı H "Possible antiapoptotic and neuroprotective effects of magnesium sulphate on retina in a preterm hypoxic-ischemic rat model." Turkish Journal of Medical Sciences, 51, ss.2198 - 2205, 2021. 10.3906/sag-2012-119
ISNAD	Imamoglu, Serhat vd. "Possible antiapoptotic and neuroprotective effects of magnesium sulphate on retina in a preterm hypoxic-ischemic rat model". Turkish Journal of Medical Sciences 51/4 (2021), 2198-2205. https://doi.org/10.3906/sag-2012-119