TY  - JOUR
TI  - Clinical Outcomes and Independent Risk Factors for 90-Day Mortality in Critically Ill Patients with Respiratory Failure Infected with SARS-CoV-2: A Multicenter Study in Turkish Intensive Care Units
AB  - Background: There are limited data on the long-term outcomes of COVID-19 from different parts of the world. Aims: To determine risk factors of 90-day mortality in critically ill patients in Turkish intensive care units (ICUs), with respiratory failure. Study design: Retrospective, observational cohort. Methods: Patients with laboratory-confirmed COVID-19 and who had been followed up in the ICUs with respiratory failure for more than 24 hours were included in the study. Their demographics, clinical characteristics, laboratory variables, treatment protocols, and survival data were recorded. Results: A total of 421 patients were included. The median age was 67 (IQR: 57-76) years, and 251 patients (59.6%) were men. The 90-day mortality rate was 55.1%. The factors independently associated with 90-day mortality were invasive mechanical ventilation (IMV) (HR 4.09 [95% CI: [2.20-7.63], P < .001), lactate level >2 mmol/L (2.78 [1.93-4.01], P < .001), age ≥60 years (2.45 [1.48-4.06)], P < .001), cardiac arrhythmia during ICU stay (2.01 [1.27-3.20], P = .003), vasopressor treatment (1.94 [1.32-2.84], P = .001), positive fluid balance of ≥600 mL/day (1.68 [1.21-2.34], P = .002), PaO2/FiO2 ratio of ≤150 mmHg (1.66 [1.18-2.32], P = .003), and ECOG score ≥1 (1.42 [1.00-2.02], P = .050). Conclusion: Long-term mortality was high in critically ill patients with COVID-19 hospitalized in intensive care units in Turkey. Invasive mechanical ventilation, lactate level, age, cardiac arrhythmia, vasopressor therapy, positive fluid balance, severe hypoxemia and ECOG score were the independent risk factors for 90-day mortality
AU  - OZYILMAZ, EZGI
AU  - FIRAT, Ahmet
AU  - ergan, begum
AU  - Esbah, Ali umit
AU  - Akbaş, Türkay
AU  - tutar, nuri
AU  - Elay, Gülseren
AU  - Turkoglu, Melda
AU  - Halacli, Burcin
AU  - Sahin, Taha Koray
AU  - YILMAZ, SEDA
AU  - Mengi, Tuğçe
AU  - Hancı, Pervin
AU  - Altintas, Neriman
AU  - akın şen, irem
AU  - ergil, julide
AU  - Kirakli, Cenk
AU  - Celik, Jale
AU  - Demirer Aydemir, Ferhan
AU  - Akbudak, İsmail hakkı
AU  - Gullu, Zuhal
AU  - ATES AYHAN, Nazire
AU  - Topeli, Arzu
AU  - AYDIN, EMRE
AU  - kara, iskender
AU  - Gündoğan, Kürşat
AU  - Zerman, Avşar
AU  - Sungur, Murat
AU  - Karakoc, Emre
AU  - Temel, Şahin
AU  - GURKOK, MEHMET CAGATAY
AU  - COMERT, BILGIN
AU  - Ulu, Ramazan
AU  - SARI, SEMA
AU  - Eryilmaz-Eren, Esma
AU  - ortaç  ersoy, nazmiye ebru
AU  - AYDOĞDU, MÜGE
AU  - Bozkurt, Firdevs Tugba
AU  - Acar Çinleti, Burcu
AU  - Ozbek, Deniz Aral
AU  - balci, canan
AU  - yildirim, fatma
AU  - ŞİMŞEK, Meltem
AU  - bilir, yeliz
AU  - açıkgöz, aslı
AU  - Gümüş, Ayça
AU  - YÜKSEL, Ümmü Gülsüm
AU  - Ferlicolak, Leyla
AU  - İnci, Kamil
AU  - Saracoglu, Kemal
AU  - Yüksel, Recep Civan
AU  - Guven, Goksel
AU  - Tor, Ibrahim Hakki
AU  - Öcal, Serpil
PY  - 2021
JO  - Balkan Medical Journal
VL  - 38
IS  - 5
SN  - 2146-3123
SP  - 296
EP  - 303
DB  - TRDizin
UR  - http://search/yayin/detay/481654
ER  -