Impact of hospital-acquired acute kidney injury on Covid-19 outcomes in patients with and without chronic kidney disease: a multicenter retrospective cohort study

Yıl: 2021 Cilt: 51 Sayı: 3 Sayfa Aralığı: 947 - 961 Metin Dili: İngilizce DOI: 10.3906/sag-2011-169 İndeks Tarihi: 17-01-2022

Impact of hospital-acquired acute kidney injury on Covid-19 outcomes in patients with and without chronic kidney disease: a multicenter retrospective cohort study

Öz:
Background/aim: Hospital-acquired acute kidney injury (HA-AKI) may commonly develop in Covid-19 patients and is expected to have higher mortality. There is little comparative data investigating the effect of HA-AKI on mortality of chronic kidney disease (CKD) patients and a control group of general population suffering from Covid-19. Materials and methods: HA-AKI development was assessed in a group of stage 3–5 CKD patients and control group without CKD among adult patients hospitalized for Covid-19. The role of AKI development on the outcome (in-hospital mortality and admission to the intensive care unit [ICU]) of patients with and without CKD was compared. Results: Among 621 hospitalized patients (age 60 [IQR: 47–73]), women: 44.1%), AKI developed in 32.5% of the patients, as stage 1 in 84.2%, stage 2 in 8.4%, and stage 3 in 7.4%. AKI developed in 48.0 % of CKD patients, whereas it developed in 17.6% of patients without CKD. CKD patients with HA-AKI had the highest mortality rate of 41.1% compared to 14.3% of patients with HA-AKI but no CKD (p < 0.001). However, patients with AKI+non-CKD had similar rates of ICU admission, mechanical ventilation, and death rate to patients with CKD without AKI. Adjusted mortality risks of the AKI+non-CKD group (HR: 9.0, 95% CI: 1.9–44.2) and AKI+CKD group (HR: 7.9, 95% CI: 1.9–33.3) were significantly higher than that of the non-AKI+non-CKD group. Conclusion: AKI frequently develops in hospitalized patients due to Covid-19 and is associated with high mortality. HA-AKI has worse outcomes whether it develops in patients with or without CKD, but the worst outcome was seen in AKI+CKD patients.Key words: Acute kidney injury, chronic kidney disease, Covid-19, hospitalization, mortality
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APA Ozturk S, turgutalp k, ARICI M, Cetinkaya H, Altiparmak M, Aydin Z, Soypacaci Z, bora f, Kara E, Cebeci E, Şenel T, DOLARSLAN M, Sipahi S, Ayar Y, Sahin I, Bakirdogen S, İSLAM M, Gorgulu N, ÖĞÜTMEN M, şengül e, Gungor O, Seyahi N, Tokgoz B, Odabas A, Tonbul H, SEZER S, YILDIZ A, Ateş K (2021). Impact of hospital-acquired acute kidney injury on Covid-19 outcomes in patients with and without chronic kidney disease: a multicenter retrospective cohort study. , 947 - 961. 10.3906/sag-2011-169
Chicago Ozturk Savas,turgutalp kenan,ARICI Mustafa,Cetinkaya Hakki,Altiparmak Mehmet Riza,Aydin Zeki,Soypacaci Zeki,bora feyza,Kara Ekrem,Cebeci Egemen,Şenel Tuba Elif,DOLARSLAN MURSIDE ESRA,Sipahi Savaş,Ayar Yavuz,Sahin Idris,Bakirdogen Serkan,İSLAM MAHMUD,Gorgulu Numan,ÖĞÜTMEN MELİKE BETÜL,şengül erkan,Gungor Ozkan,Seyahi Nurhan,Tokgoz Bulent,Odabas Ali Rıza,Tonbul Halil Zeki,SEZER SİREN,YILDIZ ALAATTIN,Ateş Kenan Impact of hospital-acquired acute kidney injury on Covid-19 outcomes in patients with and without chronic kidney disease: a multicenter retrospective cohort study. (2021): 947 - 961. 10.3906/sag-2011-169
MLA Ozturk Savas,turgutalp kenan,ARICI Mustafa,Cetinkaya Hakki,Altiparmak Mehmet Riza,Aydin Zeki,Soypacaci Zeki,bora feyza,Kara Ekrem,Cebeci Egemen,Şenel Tuba Elif,DOLARSLAN MURSIDE ESRA,Sipahi Savaş,Ayar Yavuz,Sahin Idris,Bakirdogen Serkan,İSLAM MAHMUD,Gorgulu Numan,ÖĞÜTMEN MELİKE BETÜL,şengül erkan,Gungor Ozkan,Seyahi Nurhan,Tokgoz Bulent,Odabas Ali Rıza,Tonbul Halil Zeki,SEZER SİREN,YILDIZ ALAATTIN,Ateş Kenan Impact of hospital-acquired acute kidney injury on Covid-19 outcomes in patients with and without chronic kidney disease: a multicenter retrospective cohort study. , 2021, ss.947 - 961. 10.3906/sag-2011-169
AMA Ozturk S,turgutalp k,ARICI M,Cetinkaya H,Altiparmak M,Aydin Z,Soypacaci Z,bora f,Kara E,Cebeci E,Şenel T,DOLARSLAN M,Sipahi S,Ayar Y,Sahin I,Bakirdogen S,İSLAM M,Gorgulu N,ÖĞÜTMEN M,şengül e,Gungor O,Seyahi N,Tokgoz B,Odabas A,Tonbul H,SEZER S,YILDIZ A,Ateş K Impact of hospital-acquired acute kidney injury on Covid-19 outcomes in patients with and without chronic kidney disease: a multicenter retrospective cohort study. . 2021; 947 - 961. 10.3906/sag-2011-169
Vancouver Ozturk S,turgutalp k,ARICI M,Cetinkaya H,Altiparmak M,Aydin Z,Soypacaci Z,bora f,Kara E,Cebeci E,Şenel T,DOLARSLAN M,Sipahi S,Ayar Y,Sahin I,Bakirdogen S,İSLAM M,Gorgulu N,ÖĞÜTMEN M,şengül e,Gungor O,Seyahi N,Tokgoz B,Odabas A,Tonbul H,SEZER S,YILDIZ A,Ateş K Impact of hospital-acquired acute kidney injury on Covid-19 outcomes in patients with and without chronic kidney disease: a multicenter retrospective cohort study. . 2021; 947 - 961. 10.3906/sag-2011-169
IEEE Ozturk S,turgutalp k,ARICI M,Cetinkaya H,Altiparmak M,Aydin Z,Soypacaci Z,bora f,Kara E,Cebeci E,Şenel T,DOLARSLAN M,Sipahi S,Ayar Y,Sahin I,Bakirdogen S,İSLAM M,Gorgulu N,ÖĞÜTMEN M,şengül e,Gungor O,Seyahi N,Tokgoz B,Odabas A,Tonbul H,SEZER S,YILDIZ A,Ateş K "Impact of hospital-acquired acute kidney injury on Covid-19 outcomes in patients with and without chronic kidney disease: a multicenter retrospective cohort study." , ss.947 - 961, 2021. 10.3906/sag-2011-169
ISNAD Ozturk, Savas vd. "Impact of hospital-acquired acute kidney injury on Covid-19 outcomes in patients with and without chronic kidney disease: a multicenter retrospective cohort study". (2021), 947-961. https://doi.org/10.3906/sag-2011-169
APA Ozturk S, turgutalp k, ARICI M, Cetinkaya H, Altiparmak M, Aydin Z, Soypacaci Z, bora f, Kara E, Cebeci E, Şenel T, DOLARSLAN M, Sipahi S, Ayar Y, Sahin I, Bakirdogen S, İSLAM M, Gorgulu N, ÖĞÜTMEN M, şengül e, Gungor O, Seyahi N, Tokgoz B, Odabas A, Tonbul H, SEZER S, YILDIZ A, Ateş K (2021). Impact of hospital-acquired acute kidney injury on Covid-19 outcomes in patients with and without chronic kidney disease: a multicenter retrospective cohort study. Turkish Journal of Medical Sciences, 51(3), 947 - 961. 10.3906/sag-2011-169
Chicago Ozturk Savas,turgutalp kenan,ARICI Mustafa,Cetinkaya Hakki,Altiparmak Mehmet Riza,Aydin Zeki,Soypacaci Zeki,bora feyza,Kara Ekrem,Cebeci Egemen,Şenel Tuba Elif,DOLARSLAN MURSIDE ESRA,Sipahi Savaş,Ayar Yavuz,Sahin Idris,Bakirdogen Serkan,İSLAM MAHMUD,Gorgulu Numan,ÖĞÜTMEN MELİKE BETÜL,şengül erkan,Gungor Ozkan,Seyahi Nurhan,Tokgoz Bulent,Odabas Ali Rıza,Tonbul Halil Zeki,SEZER SİREN,YILDIZ ALAATTIN,Ateş Kenan Impact of hospital-acquired acute kidney injury on Covid-19 outcomes in patients with and without chronic kidney disease: a multicenter retrospective cohort study. Turkish Journal of Medical Sciences 51, no.3 (2021): 947 - 961. 10.3906/sag-2011-169
MLA Ozturk Savas,turgutalp kenan,ARICI Mustafa,Cetinkaya Hakki,Altiparmak Mehmet Riza,Aydin Zeki,Soypacaci Zeki,bora feyza,Kara Ekrem,Cebeci Egemen,Şenel Tuba Elif,DOLARSLAN MURSIDE ESRA,Sipahi Savaş,Ayar Yavuz,Sahin Idris,Bakirdogen Serkan,İSLAM MAHMUD,Gorgulu Numan,ÖĞÜTMEN MELİKE BETÜL,şengül erkan,Gungor Ozkan,Seyahi Nurhan,Tokgoz Bulent,Odabas Ali Rıza,Tonbul Halil Zeki,SEZER SİREN,YILDIZ ALAATTIN,Ateş Kenan Impact of hospital-acquired acute kidney injury on Covid-19 outcomes in patients with and without chronic kidney disease: a multicenter retrospective cohort study. Turkish Journal of Medical Sciences, vol.51, no.3, 2021, ss.947 - 961. 10.3906/sag-2011-169
AMA Ozturk S,turgutalp k,ARICI M,Cetinkaya H,Altiparmak M,Aydin Z,Soypacaci Z,bora f,Kara E,Cebeci E,Şenel T,DOLARSLAN M,Sipahi S,Ayar Y,Sahin I,Bakirdogen S,İSLAM M,Gorgulu N,ÖĞÜTMEN M,şengül e,Gungor O,Seyahi N,Tokgoz B,Odabas A,Tonbul H,SEZER S,YILDIZ A,Ateş K Impact of hospital-acquired acute kidney injury on Covid-19 outcomes in patients with and without chronic kidney disease: a multicenter retrospective cohort study. Turkish Journal of Medical Sciences. 2021; 51(3): 947 - 961. 10.3906/sag-2011-169
Vancouver Ozturk S,turgutalp k,ARICI M,Cetinkaya H,Altiparmak M,Aydin Z,Soypacaci Z,bora f,Kara E,Cebeci E,Şenel T,DOLARSLAN M,Sipahi S,Ayar Y,Sahin I,Bakirdogen S,İSLAM M,Gorgulu N,ÖĞÜTMEN M,şengül e,Gungor O,Seyahi N,Tokgoz B,Odabas A,Tonbul H,SEZER S,YILDIZ A,Ateş K Impact of hospital-acquired acute kidney injury on Covid-19 outcomes in patients with and without chronic kidney disease: a multicenter retrospective cohort study. Turkish Journal of Medical Sciences. 2021; 51(3): 947 - 961. 10.3906/sag-2011-169
IEEE Ozturk S,turgutalp k,ARICI M,Cetinkaya H,Altiparmak M,Aydin Z,Soypacaci Z,bora f,Kara E,Cebeci E,Şenel T,DOLARSLAN M,Sipahi S,Ayar Y,Sahin I,Bakirdogen S,İSLAM M,Gorgulu N,ÖĞÜTMEN M,şengül e,Gungor O,Seyahi N,Tokgoz B,Odabas A,Tonbul H,SEZER S,YILDIZ A,Ateş K "Impact of hospital-acquired acute kidney injury on Covid-19 outcomes in patients with and without chronic kidney disease: a multicenter retrospective cohort study." Turkish Journal of Medical Sciences, 51, ss.947 - 961, 2021. 10.3906/sag-2011-169
ISNAD Ozturk, Savas vd. "Impact of hospital-acquired acute kidney injury on Covid-19 outcomes in patients with and without chronic kidney disease: a multicenter retrospective cohort study". Turkish Journal of Medical Sciences 51/3 (2021), 947-961. https://doi.org/10.3906/sag-2011-169