The preventive role of medical ozone therapy on remote organ injury induced by hepatic ischemia reperfusion

Demirtas, Levent; Biçer, Şenol; AKBAS, EMIN MURAT; Gürsul, Cebrail; SAYAR, ILYAS; GÜRBÜZEL, MEHMET; gurbuzel, ahmet

The preventive role of medical ozone therapy on remote organ injury induced by hepatic ischemia reperfusion

Levent Demirtas, (Erzincan Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı, Erzincan, Türkiye)

Cebrail Gürsul, (Erzincan Üniversitesi Tıp Fakültesi Fizyoloji Anabilim Dalı, Erzincan, Türkiye)

Ahmet Gurbuzel, (Yüksekova Devlet Hastanesi, Göğüs Hastalıkları Anabilim Dalı, Hakkari, Türkiye)

ILYAS SAYAR, (Erzincan Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı, Erzincan, Türkiye)

Mehmet GÜRBÜZEL, (Erzincan Üniversitesi Tıp Fakültesi Tıbbi Biyoloji Anabilim Dalı, Erzincan, Türkiye)

Şenol BİÇER, (Erzincan Üniversitesi Tıp Fakültesi Çocuk Cerrahisi Anabilim Dalı, Erzincan, Türkiye)

EMİN MURAT AKBAŞ (Erzincan Üniversitesi Tıp Fakültesi Endokrinoloji Anabilim Dalı, Erzincan, Türkiye)

Annals of Medical Research

2 0

Yıl: 2021 Cilt: 28 Sayı: 9 Sayfa Aralığı: 1671 - 1676 Metin Dili: İngilizce İndeks Tarihi: 17-01-2022

The preventive role of medical ozone therapy on remote organ injury induced by hepatic ischemia reperfusion

Öz:

Aim: This study explores the effects of ozone therapy on the prevention of remote organ injury in rats with induced hepatic ischemiareperfusion injury. Materials and Methods: Twenty-one male Sprague Dawley rats were sorted randomly into three groups: (a) A control group in which the rats’ abdomens were operated on by laparotomy, and their livers then viewed and closed with a suture; (b) Rats with induced hepatic ischemia-reperfusion injuries; and (c) Rats induced with the same injuries that were administered ozone therapy before reperfusion. The rats’ hepatic arteries, portal veins, and bile ducts were clamped, and ischemia was induced for 45 min. Reperfusion was provided for 90 min in the second and third groups. The third group was administered 0.5 mg/kg ozone intraperitoneally before reperfusion. Liver, lung, and kidney tissues were taken for biochemical and histopathological examinations. Results: In the second group, malondialdehyde levels in the lung and kidney tissues were higher than in the control group, while catalase and superoxide dismutase enzyme levels were lower. The third group had lower malondialdehyde levels and higher catalase and superoxide dismutase enzyme levels than the group that did not receive the therapy. In histopathological evaluations, the damage to both kidney and lung tissues in the third group was higher than in the control group; however, this damage was significantly lower than in the second group. Conclusions: The findings indicated that the administration of ozone therapy attenuated lung and kidney injuries caused by hepatic ischemia, since partial protection was demonstrated in many instances.

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APA	Demirtas L, Gürsul C, gurbuzel a, SAYAR I, GÜRBÜZEL M, Biçer Ş, AKBAS E (2021). The preventive role of medical ozone therapy on remote organ injury induced by hepatic ischemia reperfusion. , 1671 - 1676.
Chicago	Demirtas Levent,Gürsul Cebrail,gurbuzel ahmet,SAYAR ILYAS,GÜRBÜZEL MEHMET,Biçer Şenol,AKBAS EMIN MURAT The preventive role of medical ozone therapy on remote organ injury induced by hepatic ischemia reperfusion. (2021): 1671 - 1676.
MLA	Demirtas Levent,Gürsul Cebrail,gurbuzel ahmet,SAYAR ILYAS,GÜRBÜZEL MEHMET,Biçer Şenol,AKBAS EMIN MURAT The preventive role of medical ozone therapy on remote organ injury induced by hepatic ischemia reperfusion. , 2021, ss.1671 - 1676.
AMA	Demirtas L,Gürsul C,gurbuzel a,SAYAR I,GÜRBÜZEL M,Biçer Ş,AKBAS E The preventive role of medical ozone therapy on remote organ injury induced by hepatic ischemia reperfusion. . 2021; 1671 - 1676.
Vancouver	Demirtas L,Gürsul C,gurbuzel a,SAYAR I,GÜRBÜZEL M,Biçer Ş,AKBAS E The preventive role of medical ozone therapy on remote organ injury induced by hepatic ischemia reperfusion. . 2021; 1671 - 1676.
IEEE	Demirtas L,Gürsul C,gurbuzel a,SAYAR I,GÜRBÜZEL M,Biçer Ş,AKBAS E "The preventive role of medical ozone therapy on remote organ injury induced by hepatic ischemia reperfusion." , ss.1671 - 1676, 2021.
ISNAD	Demirtas, Levent vd. "The preventive role of medical ozone therapy on remote organ injury induced by hepatic ischemia reperfusion". (2021), 1671-1676.

APA	Demirtas L, Gürsul C, gurbuzel a, SAYAR I, GÜRBÜZEL M, Biçer Ş, AKBAS E (2021). The preventive role of medical ozone therapy on remote organ injury induced by hepatic ischemia reperfusion. Annals of Medical Research, 28(9), 1671 - 1676.
Chicago	Demirtas Levent,Gürsul Cebrail,gurbuzel ahmet,SAYAR ILYAS,GÜRBÜZEL MEHMET,Biçer Şenol,AKBAS EMIN MURAT The preventive role of medical ozone therapy on remote organ injury induced by hepatic ischemia reperfusion. Annals of Medical Research 28, no.9 (2021): 1671 - 1676.
MLA	Demirtas Levent,Gürsul Cebrail,gurbuzel ahmet,SAYAR ILYAS,GÜRBÜZEL MEHMET,Biçer Şenol,AKBAS EMIN MURAT The preventive role of medical ozone therapy on remote organ injury induced by hepatic ischemia reperfusion. Annals of Medical Research, vol.28, no.9, 2021, ss.1671 - 1676.
AMA	Demirtas L,Gürsul C,gurbuzel a,SAYAR I,GÜRBÜZEL M,Biçer Ş,AKBAS E The preventive role of medical ozone therapy on remote organ injury induced by hepatic ischemia reperfusion. Annals of Medical Research. 2021; 28(9): 1671 - 1676.
Vancouver	Demirtas L,Gürsul C,gurbuzel a,SAYAR I,GÜRBÜZEL M,Biçer Ş,AKBAS E The preventive role of medical ozone therapy on remote organ injury induced by hepatic ischemia reperfusion. Annals of Medical Research. 2021; 28(9): 1671 - 1676.
IEEE	Demirtas L,Gürsul C,gurbuzel a,SAYAR I,GÜRBÜZEL M,Biçer Ş,AKBAS E "The preventive role of medical ozone therapy on remote organ injury induced by hepatic ischemia reperfusion." Annals of Medical Research, 28, ss.1671 - 1676, 2021.
ISNAD	Demirtas, Levent vd. "The preventive role of medical ozone therapy on remote organ injury induced by hepatic ischemia reperfusion". Annals of Medical Research 28/9 (2021), 1671-1676.