Comparison of the renal response of bortezomib-based induction and conventional regimen in multiple myeloma patients with renal failure
Yıl: 2021 Cilt: 28 Sayı: 10 Sayfa Aralığı: 1824 - 1829 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2021.01.098 İndeks Tarihi: 18-01-2022
Comparison of the renal response of bortezomib-based induction and conventional regimen in multiple myeloma patients with renal failure
Öz: Aim: Vincristine-doxorubicin-dexamethasone (VAD) was the commonly used first-line treatment for multiple myeloma (MM) patients with renal failure before bortezomib entered clinical practice. In this trial, we aimed to compare the effect of VAD and bortezomibcyclophosphamide-dexamethasone (VCD) chemotherapy regimens on improving kidney function in MM patients with renal failure. Materials and Methods: The records of MM patients in our center between January 2010 and February 2020 were retrospectively analyzed. Patients who received VAD or VCD as a first treatment chemotherapy protocol and whose initially estimated glomerular filtration rate (eGFR) was 50 mL/min/1.73 m2and below were included in the study. Patients were divided into two groups according to the chemotherapy regimens they received. Results: Sixty one MM patients (VAD: 26, VCD: 35) were included in the study. No significant difference was found between the VAD and VCD groups when the baseline, 1st and 2nd month eGFRs were compared (p>0.05). Overall renal response rate (at least minor response) in the VCD group at the end of the 1st month were higher than in the VAD group (p=0.002). Also, renal response rate in the VCD group at the end of the 2nd month were higher than in the VAD group (p=0.033). Conclusion: In MM patients with renal insufficiency, overall renal response rates have increased with the use of VCD instead of VAD as a standard induction regimen.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | SARİCİ A, KAYA E, ERKURT M, BERBER I, Tanriverdi L, BAHCECİOGLU O, GOK S, KUKU I (2021). Comparison of the renal response of bortezomib-based induction and conventional regimen in multiple myeloma patients with renal failure. , 1824 - 1829. 10.5455/annalsmedres.2021.01.098 |
| Chicago | SARİCİ Ahmet,KAYA Emin,ERKURT Mehmet Ali,BERBER Ilhami,Tanriverdi Lokman Hekim,BAHCECİOGLU Omer Faruk,GOK Selim,KUKU Irfan Comparison of the renal response of bortezomib-based induction and conventional regimen in multiple myeloma patients with renal failure. (2021): 1824 - 1829. 10.5455/annalsmedres.2021.01.098 |
| MLA | SARİCİ Ahmet,KAYA Emin,ERKURT Mehmet Ali,BERBER Ilhami,Tanriverdi Lokman Hekim,BAHCECİOGLU Omer Faruk,GOK Selim,KUKU Irfan Comparison of the renal response of bortezomib-based induction and conventional regimen in multiple myeloma patients with renal failure. , 2021, ss.1824 - 1829. 10.5455/annalsmedres.2021.01.098 |
| AMA | SARİCİ A,KAYA E,ERKURT M,BERBER I,Tanriverdi L,BAHCECİOGLU O,GOK S,KUKU I Comparison of the renal response of bortezomib-based induction and conventional regimen in multiple myeloma patients with renal failure. . 2021; 1824 - 1829. 10.5455/annalsmedres.2021.01.098 |
| Vancouver | SARİCİ A,KAYA E,ERKURT M,BERBER I,Tanriverdi L,BAHCECİOGLU O,GOK S,KUKU I Comparison of the renal response of bortezomib-based induction and conventional regimen in multiple myeloma patients with renal failure. . 2021; 1824 - 1829. 10.5455/annalsmedres.2021.01.098 |
| IEEE | SARİCİ A,KAYA E,ERKURT M,BERBER I,Tanriverdi L,BAHCECİOGLU O,GOK S,KUKU I "Comparison of the renal response of bortezomib-based induction and conventional regimen in multiple myeloma patients with renal failure." , ss.1824 - 1829, 2021. 10.5455/annalsmedres.2021.01.098 |
| ISNAD | SARİCİ, Ahmet vd. "Comparison of the renal response of bortezomib-based induction and conventional regimen in multiple myeloma patients with renal failure". (2021), 1824-1829. https://doi.org/10.5455/annalsmedres.2021.01.098 |
| APA | SARİCİ A, KAYA E, ERKURT M, BERBER I, Tanriverdi L, BAHCECİOGLU O, GOK S, KUKU I (2021). Comparison of the renal response of bortezomib-based induction and conventional regimen in multiple myeloma patients with renal failure. Annals of Medical Research, 28(10), 1824 - 1829. 10.5455/annalsmedres.2021.01.098 |
| Chicago | SARİCİ Ahmet,KAYA Emin,ERKURT Mehmet Ali,BERBER Ilhami,Tanriverdi Lokman Hekim,BAHCECİOGLU Omer Faruk,GOK Selim,KUKU Irfan Comparison of the renal response of bortezomib-based induction and conventional regimen in multiple myeloma patients with renal failure. Annals of Medical Research 28, no.10 (2021): 1824 - 1829. 10.5455/annalsmedres.2021.01.098 |
| MLA | SARİCİ Ahmet,KAYA Emin,ERKURT Mehmet Ali,BERBER Ilhami,Tanriverdi Lokman Hekim,BAHCECİOGLU Omer Faruk,GOK Selim,KUKU Irfan Comparison of the renal response of bortezomib-based induction and conventional regimen in multiple myeloma patients with renal failure. Annals of Medical Research, vol.28, no.10, 2021, ss.1824 - 1829. 10.5455/annalsmedres.2021.01.098 |
| AMA | SARİCİ A,KAYA E,ERKURT M,BERBER I,Tanriverdi L,BAHCECİOGLU O,GOK S,KUKU I Comparison of the renal response of bortezomib-based induction and conventional regimen in multiple myeloma patients with renal failure. Annals of Medical Research. 2021; 28(10): 1824 - 1829. 10.5455/annalsmedres.2021.01.098 |
| Vancouver | SARİCİ A,KAYA E,ERKURT M,BERBER I,Tanriverdi L,BAHCECİOGLU O,GOK S,KUKU I Comparison of the renal response of bortezomib-based induction and conventional regimen in multiple myeloma patients with renal failure. Annals of Medical Research. 2021; 28(10): 1824 - 1829. 10.5455/annalsmedres.2021.01.098 |
| IEEE | SARİCİ A,KAYA E,ERKURT M,BERBER I,Tanriverdi L,BAHCECİOGLU O,GOK S,KUKU I "Comparison of the renal response of bortezomib-based induction and conventional regimen in multiple myeloma patients with renal failure." Annals of Medical Research, 28, ss.1824 - 1829, 2021. 10.5455/annalsmedres.2021.01.098 |
| ISNAD | SARİCİ, Ahmet vd. "Comparison of the renal response of bortezomib-based induction and conventional regimen in multiple myeloma patients with renal failure". Annals of Medical Research 28/10 (2021), 1824-1829. https://doi.org/10.5455/annalsmedres.2021.01.098 |
