Nm23 and HER2/neu gene expression and prognostic significance in urothelial carcinomas of the bladder

ARSLAN, REMZİ; Erdoğan, Fazlı

doi:10.5455/annalsmedres.2021.01.018

Nm23 and HER2/neu gene expression and prognostic significance in urothelial carcinomas of the bladder

Remzi Arslan, (Atatürk Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı, Erzurum, Türkiye)

Fazlı ERDOĞAN (Yıldırım Beyazıt Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı, Ankara, Türkiye)

Annals of Medical Research

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Yıl: 2021 Cilt: 28 Sayı: 11 Sayfa Aralığı: 1978 - 1985 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2021.01.018 İndeks Tarihi: 18-01-2022

Nm23 and HER2/neu gene expression and prognostic significance in urothelial carcinomas of the bladder

Öz:

Aim: This study aimed to investigate the expressions of Nm23-H1 and HER2/neu in Turkish cases of urothelial carcinomas of bladder and to examine their associations with prognostic parameters. Urothelial carcinoma of the bladder is one of the most prevalent cancers worldwide. Nm23-H1 and HER2/neu expressions have been previously studied in urothelial carcinomas. Despite the availability of many reports in the literature, the prognostic significance of these expressions remains unclear. Materials and Methods: Fifty cases of urothelial carcinoma of the bladder treated with radical cystectomy were retrospectively reviewed. The tumor specimens were evaluated by immunohistochemistry using Nm23-H1 and HER2/neu antibodies. Results: Immunohistochemically, Nm23-H1 and HER2/neu expressions were present in 80% and 18% of cases and associated with pathological stage (p=0.025 and p=0.023, respectively). Conclusion: Both antibodies were noted in patients with advanced stage cancer, which can adversely affect prognosis in infiltrative urothelial carcinomas of the bladder. HER2/neu may be a target for therapy

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ARSLAN R, Erdoğan F (2021). Nm23 and HER2/neu gene expression and prognostic significance in urothelial carcinomas of the bladder. , 1978 - 1985. 10.5455/annalsmedres.2021.01.018
Chicago	ARSLAN REMZİ,Erdoğan Fazlı Nm23 and HER2/neu gene expression and prognostic significance in urothelial carcinomas of the bladder. (2021): 1978 - 1985. 10.5455/annalsmedres.2021.01.018
MLA	ARSLAN REMZİ,Erdoğan Fazlı Nm23 and HER2/neu gene expression and prognostic significance in urothelial carcinomas of the bladder. , 2021, ss.1978 - 1985. 10.5455/annalsmedres.2021.01.018
AMA	ARSLAN R,Erdoğan F Nm23 and HER2/neu gene expression and prognostic significance in urothelial carcinomas of the bladder. . 2021; 1978 - 1985. 10.5455/annalsmedres.2021.01.018
Vancouver	ARSLAN R,Erdoğan F Nm23 and HER2/neu gene expression and prognostic significance in urothelial carcinomas of the bladder. . 2021; 1978 - 1985. 10.5455/annalsmedres.2021.01.018
IEEE	ARSLAN R,Erdoğan F "Nm23 and HER2/neu gene expression and prognostic significance in urothelial carcinomas of the bladder." , ss.1978 - 1985, 2021. 10.5455/annalsmedres.2021.01.018
ISNAD	ARSLAN, REMZİ - Erdoğan, Fazlı. "Nm23 and HER2/neu gene expression and prognostic significance in urothelial carcinomas of the bladder". (2021), 1978-1985. https://doi.org/10.5455/annalsmedres.2021.01.018

APA	ARSLAN R, Erdoğan F (2021). Nm23 and HER2/neu gene expression and prognostic significance in urothelial carcinomas of the bladder. Annals of Medical Research, 28(11), 1978 - 1985. 10.5455/annalsmedres.2021.01.018
Chicago	ARSLAN REMZİ,Erdoğan Fazlı Nm23 and HER2/neu gene expression and prognostic significance in urothelial carcinomas of the bladder. Annals of Medical Research 28, no.11 (2021): 1978 - 1985. 10.5455/annalsmedres.2021.01.018
MLA	ARSLAN REMZİ,Erdoğan Fazlı Nm23 and HER2/neu gene expression and prognostic significance in urothelial carcinomas of the bladder. Annals of Medical Research, vol.28, no.11, 2021, ss.1978 - 1985. 10.5455/annalsmedres.2021.01.018
AMA	ARSLAN R,Erdoğan F Nm23 and HER2/neu gene expression and prognostic significance in urothelial carcinomas of the bladder. Annals of Medical Research. 2021; 28(11): 1978 - 1985. 10.5455/annalsmedres.2021.01.018
Vancouver	ARSLAN R,Erdoğan F Nm23 and HER2/neu gene expression and prognostic significance in urothelial carcinomas of the bladder. Annals of Medical Research. 2021; 28(11): 1978 - 1985. 10.5455/annalsmedres.2021.01.018
IEEE	ARSLAN R,Erdoğan F "Nm23 and HER2/neu gene expression and prognostic significance in urothelial carcinomas of the bladder." Annals of Medical Research, 28, ss.1978 - 1985, 2021. 10.5455/annalsmedres.2021.01.018
ISNAD	ARSLAN, REMZİ - Erdoğan, Fazlı. "Nm23 and HER2/neu gene expression and prognostic significance in urothelial carcinomas of the bladder". Annals of Medical Research 28/11 (2021), 1978-1985. https://doi.org/10.5455/annalsmedres.2021.01.018